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B13R

Gene
B13R
Protein
Protein B14
Organism
Variola virus (isolate Human/India/Ind3/1967)
Length
149 amino acids
Function
Contributes to virulence by binding to the host IKBKB subunit of the IKK complex and preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B.
Similarity
Belongs to the poxviridae B14 protein family.
Mass
17.369 kDa
Sequence
MTANFSTHVFSPQHCGCDRLTSIDDVRQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDAESVFIDVRELVKNMPWDDVKDCVEIIRCYIPDEQKTIREISAIIGLCAYAATYWGGEDHPTSNSLNALFVMLKMLNYVDYNIIFRRMN

Gene
B13R
Protein
Putative serine proteinase inhibitor 2 homolog first part
Organism
Vaccinia virus (strain Copenhagen)
Length
116 amino acids
Similarity
Belongs to the serpin family. Poxviruses subfamily.
Mass
12.849 kDa
Sequence
MKGENVFISPASISSVLTILYYGANGSTAEQLSKYVETEENTDKVSAQNISFKSINKVYGRYSAVFKDFFLGKIGDKFQTVDFTDCRTIDAINKCVDIFTEGKINPLLDEPLSPSN