Organism
Variola virus (isolate Human/India/Ind3/1967)
Function
Contributes to virulence by binding to the host IKBKB subunit of the IKK complex and preventing host NF-kappa-B activation in response to pro-inflammatory stimuli such as TNF-alpha or IL1B.
Similarity
Belongs to the poxviridae B14 protein family.
Sequence
MTANFSTHVFSPQHCGCDRLTSIDDVRQCLTEYIYWSSYAYRNRQCAGQLYSTLLSFRDDAESVFIDVRELVKNMPWDDVKDCVEIIRCYIPDEQKTIREISAIIGLCAYAATYWGGEDHPTSNSLNALFVMLKMLNYVDYNIIFRRMN