Protein
Delta(1)-pyrroline-2-carboxylate reductase
Organism
Agrobacterium fabrum (strain C58 / ATCC 33970)
Function
Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using NADPH as the electron donor. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow A.tumefaciens to grow on t3LHyp as a sole carbon source.
Similarity
Belongs to the LDH2/MDH2 oxidoreductase family.
Sequence
MSDTTTLTIEALFQRVESIFLRAGLNAVQSGALARVITAGERDACKSHGIYRIEGALRTVKAAKVKPDAIPEVAEDDGTAIVKVNAMGGFANPAFELGLPALAERAKRLGLAALVINDCTHFSALWPEVEGLTSNGLAGLVMCPSYSTVAPTGGTKPLLGTNPFAFGWPRKDTSPYVFDFATSVAARGEIELHRRARKSLPEGWAVDADGNPTTDPEAALAGAMLPFGGHKGSAIGTMIELLAGIMIGDLTSPEVLDYLGTTTLAPFHGELIVAFSPEAFAKGRPGDPFQRAEVLFEAIIGQGARLPSGRRFAARAKSESEGITLTAAEMAGLDRLLEKGLDAVS