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Atm

Gene
ATM
Protein
Serine/threonine-protein kinase ATM
Organism
Arabidopsis thaliana
Length
3856 amino acids
Function
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR) or DNA replication stalling. Plays a central role in the perception and response to both stress-induced damage in somatic cells and developmentally programmed DNA damage during meiosis. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone variant H2AX to form H2AXS139ph at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Involved in transcriptional regulation of RAD51, PARP1, GR1, and LIG4 in response to DNA double strand breaks. Plays a dual role by activating the DNA damage response at dysfunctional telomeres and yet preventing this activation at functional telomeres. Not required for telomere length homeostasis. Regulates DNA damage response (DDR) synergistically with RUG3. Together with RUG3, involved in the splicing of the ND2/NAD2 mRNA (PubMed:28262819).
Similarity
Belongs to the PI3/PI4-kinase family.
Mass
435.114 kDa
Sequence
MKLQNPDKKTLREGFSQESSVVALDSGVLAMSGLKCDGKFPVKDVLMEEGGDKVRKIQVSGGNISLVVDFSGARTSSNNFFESNASCVNENLVKGNGYREDETQEFLVGNLVWVMTKYKKWWPGEVVDFKADAKESFMVRSIGQSHLVSWFASSKLKPFKESFEQVLNQRNDNGFFDALQKAMSLLSNSLKLDMTCSCIADGNGIVSAQNITTRKNKPLILREFSVDRLEPKEFVTQLKNIAKCVLNAGVLESTVMQSQLSAFYTLFGHKQIPMAQLHENEGRKSFTAKMSDSKFIGSPSICAGNSRKRFRKEWFRKFVSEVDNVSARDDLVNVPPSDLISKLKLLAVGYNCSEETENIGLFEWFFSKFRISVYHDENAYKMQLANMAGFKDLMLATNANRGTVQKTLKSKKIGKSKMEPLNGVSVADTEQKTFELQISKKSNIESLNGVSVADTEQKTFELQILEKSNIESLNGVSTPNIDHEASKSNNSGKTKINHIIGHSNFPSSVAKVQLAKDFQDKLLVQAPDRKAMTADTLSRPAAILVPDLNSGGNALGTAEFDHMQRPETLIQHNVCPQEEKTPRSTILNFQVTAHQGVSGTQFVSSQPTSYKHFTSADLFTYSGKKKRGRKRKNAEELPIVAHASATTGIPDLNGTNTEPTLVLPQVEPTQRRRRRKKEESPNGLTRGITILFLKFSSQVSMPSRDDLTSTFSAFGPLDSSETHVSEEFSGAQVAFVSSADAIEAVKSLEKANPFGETLVNFRLQQKLITVQRNIAPRMPVISHVSPVPKPNNIPTSMDAMRQNLLMMTAMLEKSGDSLSRETKAKLKSEITGLLEKDGVKLLNTWLEGERSITFCRFLSQNTAKLKLDEIPNAETWPFLVKLLLQCVSMEVSGSKRRMPKPTFAKTLRVVVQRTEETKFPGVQFPLLSMAKTLFTHVHDILSNTPSFQSEYGTILRHLLEIKEYRFQMRKRTYSSLVLLYMERAETGFCEKNSGQHSQKEEAFRYILTLQSLLENSPGDFPDDLREEIVNGLIHIFSSVRDEGKLSRKLIECVNTFLLKDGPNLGSLSLEIHNAVEQFVFRCWLTTHDKNLKEILVSYGRLQLNLTRDSSESSSLVEQLLDVVTRELDLGSSSSSASWGDTTKDEKLGALSSYQNSLVELAAHVFYRACVNTSRPSLSEKRARRQHIAMRMVDALTEGKWLWCAAFGCLVRNYCARINMDLLIYWFEAICTNFQRLLEDASMRRSYDGLLWTLRSLQGLSSGLSLPDITMDISKSSASSSELDRGWQSIWSSLIHGLATFSSMSVIVDAVLVLLGSIISSNHITVKILPQEVWDHQLFRHIPSEPALYFIACYFSRMGCQGNLQDDLHLRRNLLRAVCAPLSWKVRLTLDERMVQLLPAAAFSLCAGFKVSLPLPKEHLPTPSQWDVCEQIDDVDRERNFGLFECSVEALTRICSNSSKISGCQVPDVVQLPLVLRDPLLHDMDIYFLSIIPEVKEKGPLSDIFMGCALLCHFMHGSYITRKGKGSSSFFLKACQYLLEGLDHAVESVSKSLNDLQRRGSLGFGSDFNEKGSIIVSLRSFTQSPVFSNRRDQNLLGASYDFVIHSLENLLRSFAKVYEEYTEHAWNTHSDTVPSKSLAPDSPEVGRIVDMDLDLAEDTKERDIIAAGGKAVPGLPVSMGNWKLGMVSLISCFSPVLQFPTWDVLYNLLEKESDPKVLENILYHLCKLSCLTSIPKVDDLVIFLDGMLSTQVKMKRNCLNIVTALHVLLHTLSSSRRDSSGVEKNCGLSLKEAESFQVFVQLGAMVNKVSEFGLLGWFGRVKLINCICDLVLLNPQTGQTMIERLLLMLSDSDYRVRFVLARQIGILFQTWDGHEALFQDICSSFGIKLVTSSKEKLVTAKDVLAVGPQPRQKMETVIITLMHLAYHSENIELQAVFMMCAVSAKDPCQRELIIAALDNLSAQLHYPSRFKYLEELLGPILFHWIASGVSLAGLIETSQLFIPNAEPKYFIHFCSHWLLPALLLHEDHTNLDWVAKMAGQPVVVLVKENFVPIFSICMGLHCSKTSECDKGAMVLQNSILYVGETSENERDKLIKQNMVSIVSFILSCASSSPEPPVPTFSRDTISLAVQTVVDGFLENTDYPKNAAITDRINIFRPDRVFMFITEMHYRMSAACHHRHTRHHLAALEELTILLGHRALVPSSLNYIFNLVGQFIGYPSLQDQCCSIASCLLDLFKSNPAKEIVSVLGDQLQFLVSKLVTCCIDAEADTKISGAKSSQLVNLLHKLVVSSDSSLNEDIRDLEPLPDLKYFQVIRESHIRICEAYSPRNHLLKVEHSTFLIYIFLEILSLSNFLFLSCSTIQQCSRRSNYLPPRFLSRSLQALHNKLIASEVSQEDTNGETAETFWQSDDEIVNAVWTLVRVSASDEADSMRLLVSDFLSRIGIRDPHTVVFHLPGNLVSMHGLQGFGHNTGSKVRSLTENGISDETLITLLNFLKKYLLDDSVKIIDVTSQTLRGILSTERGQQALSSFDSCERALIEVHGRGVNLDIVEKILLDSQKQFKAEKFSLETPEVWSTDNKNFDRWICQLVYCMIALCEDVPIRLCQNIALLKAEISELLFPSVVVSLAGRIGMDINLHDLITSQVKEHIFTDSNKLTKSKQVMLNTLNELRMCYVLERSIFSGQTKREKNSRSCSTAAKIRDVESGSNGMAASITTNWEKVYWLSIDYLVVAGSAVVCGAYLTASMYVEYWCEEKFGNLSLGDPDFSYHDKLPDHVEILVSAITRINEPDSLYGVIHSNKLSAQIITFEHEGNWTRALEYYDLQARSQKMVVPSSLSENLEVEQFQPTTSARHSVFGEGEVQRQPFKGLIRSLQQTGCMHVLDLYCRGLTSREGCFQYDPEFIELQYEAAWRAGKWDFSLLYPQTHCQPLQHAKNNNYHESLHCCLRALQEGDYDGFYGKLKDTKKELVLSISRASEESTEFIYSTVVKLQILHHLGLVWDLRWTTSSHQSVHGYLVKQMACVDPVIPTMDQLSWLNKDWNSIITQTQLHMTLLEPFIAFRRVLLQILGCEKCTMQHLLQSASLLRKGTRFSHAAASLHEFKFLCARSNGQQPVPDWLGKLEEAKLLHAQGRHEVSISLANYILHNYQLKEEASDIYRVIGKWLAETRSSNSRTILEKYLRPAVSLAEEQSSKICKRLVDRQSQTWFHLAHYADALFKSYEERLSSSEWQAALRLRKHKTKELEVFIKRFKSSKKAEQSDYSLKIQDLQKQLTMDKEEAEKLQVDRDNFLKLALEGYKRCLEIGDKYDVRVVFRQVSMWFSLASQKNVIDNMLSTIKEVQSYKFIPLVYQIASRLGSSKDESGSNSFQSALVSLIRKMAIDHPYHTILQLLALANGDRIKDNQRSRNSFVVDMDKKLAAEHLLQDVSHYHGPMIRQMKQLVDIYIKLAELETRREDTNRKVALPREIRSVKQLELVPVVTATIPVDRSCQYNEGSFPFFRGLSDSVTVMNGINAPKVVECFGSDGQKYKQLAKSGNDDLRQDAVMEQFFGLVNTFLHNNRDTWKRRLAVRTYKVIPFTPSAGVLEWVDGTIPLGDYLIGSSRSEGAHGRYGIGNWKYPKCREHMSSAKDKRKAFVDVCTNFRPVMHYFFLEKFLQPADWFVKRLAYTRSVAASSMVGYIVGLGDRHAMNILIDQATAEVVHIDLGVAFEQGLMLKTPERVPFRLTRDIIDGMGITGVEGVFRRCCEETLSVMRTNKEALLTIVEVFIHDPLYKWALSPLKALQRQKETEDYDGMNLEGLQEEFEGNKDATRALMRVKQKLDGYEGGEMRSIHGQAQQLIQDAIDTDRLSHMFPGWGAWM

Gene
Atm
Protein
Serine-protein kinase ATM
Organism
Mus musculus
Length
3066 amino acids
Function
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
Similarity
Belongs to the PI3/PI4-kinase family. ATM subfamily.
Mass
349.418 kDa
Sequence
MSLALNDLLICCRQLEHDRATERRKEVDKFKRLIQDPETVQHLDRHSDSKQGKYLNWDAVFRFLQKYIQKEMESLRTAKSNVSATTQSSRQKKMQEISSLVRYFIKCANKRAPRLKCQDLLNYVMDTVKDSSNGLTYGADCSNILLKDILSVRKYWCEVSQQQWLELFSLYFRLYLKPSQDINRVLVARIIHAVTRGCCSQTDGLPSKFLDLFSKAIQYARQEKSSPGLSHILAALNIFLKSLAVNFRKRVCEAGDEILPTLLYIWTQHRLNDSLKEVIIELIQLQIYIHHPQGARAPEEGAYESMKWKSILYNLYDLLVNEISHIGSRGKYSSGSRNIAVKENLIDLMADICYQLFDADTRSVEISQSYVTQRESTDYSVPCKRRKIDVGWEVIKDYLQKSQSDFDLVPWLQITTRLISKYPSSLPNCELSPLILILYQLLPQQRRGERIPYVLRCLKEVALCQGKKSNLESSQKSDLLKLWIKIWSITFRGISSGQTQTENFGLLEAIIQGSLVELDREFWKLFTGSACKPSSPSVCCLTLALSICVVPDAIKMGTEQSVCEANRSFSVKESIMRWLLFYQLEDDLEDSTELPPILQSNFPHLVVEKILVSLTMKNSKAAMKFFQSVPECEQHCEDKEEPSFSEVEELFLQTTFDKMDFLTTVKEYAVEKFQSSVGFSVQQNLKESLDHYLLGLSEQLLSNYSSEITSSETLVRCSSLLVGVLGCYCYMGIITEDEAHKSELFQKAKSLMQCAGESISLFKNKTNEESRIGSLRNVMHLCTSCLCIHTKHTPNKIASGFFLRLLTSKLMNDIADICKSLASCTKKPLDHGVHPGEDDEDGGGCDSLMEAEGPSSTGLSTAYPASSVSDANDYGENQNAVGAMSPLAADYLSKQDHLLLDMLRFLGRSVTASQSHTVSFRGADIRRKLLLLLDSSILDLMKPLHLHMYLVLLKDLPGNEHSLPMEDVVELLQPLSLVCSLHRRDQDVCKTILSNVLHIVTNLGQGSVDMESTRIAQGHFLTVMGAFWHLTKEKKCVFSVRMALVKCLQTLLEADPYSEWAILNVKGQDFPVNEAFSQFLADDHHQVRMLAAGSVNRLFQDMRQGDFSRSLKALPLKFQQTSFNNAYTTAEAGIRGLLCDSQNPDLLDEIYNRKSVLLMMIAVVLHCSPVCEKQALFALCKSVKENRLEPHLVKKVLEKVSESFGCRSLEDFMISHLDYLVLEWLNLQDTEYSLSSFPFMLLNYTSIEDFYRSCYKILIPHLVIRSHFDEVKSIANQIQKCWKSLLVDCFPKILVHILPYFAYEGTRDSYVSQKRETATKVYDTLKGEDFLGKQIDQVFISNLPEIVVELLMTLHETADSADSDASQSATALCDFSGDLDPAPNPPYFPSHVIQATFAYISNCHKTKFKSILEILSKIPDSYQKILLAICEQAAETNNVFKKHRILKIYHLFVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYINKRSSHFTDVSLRSFSLCCDLLSRVCHTAVTQCKDALESHLHVIVGTLIPLVDYQEVQEQVLDLLKYLVIDNKDNKNLSVTIKLLDPFPDHVIFKDLRLTQQKIKYSGGPFSLLEEINHFLSVSAYNPLPLTRLEGLKDLRRQLEQHKDQMLDLLRASQDNPQDGIVVKLVVSLLQLSKMAVNQTGEREVLEAVGRCLGEIGPLDFSTIAVQHNKDVSYTKAYGLPEDRELQWTLIMLTALNNTLVEDSVKIRSAAATCLKNILATKIGHIFWENYKTSADPMLTYLQPFRTSRKKFLEVPRSVKEDVLEGLDAVNLWVPQSESHDIWIKTLTCAFLDSGGINSEILQLLKPMCEVKTDFCQMLLPYLIHDVLLQDTHESWRTLLSAHVRGFFTSCFKHSSQASRSATPANSDSESENFLRCCLDKKSQRTMLAVVDYLRRQKRPSSGTAFDDAFWLDLNYLEVAKVAQSCSAHFTALLYAEIYSDKKSTDEQEKRSPTFEEGSQGTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPLTRIRTYEHEATWEKALVTYDLETSISSSTRQSGIIQALQNLGLSHILSVYLKGLDYERREWCAELQELRYQAAWRNMQWGLCASAGQEVEGTSYHESLYNALQCLRNREFSTFYESLRYASLFRVKEVEELSKGSLESVYSLYPTLSRLQAIGELENSGELFSRSVTDRERSEAYWKWQKHSQLLKDSDFSFQEPLMALRTVILETLVQKEMERSQGACSKDILTKHLVEFSVLARTFKNTQLPERAIFKIKQYNSAICGISEWHLEEAQVFWAKKEQSLALSILKQMIKKLDSSFKDKENDAGLKVIYAECLRVCGSWLAETCLENPAVIMQTYLEKAVKVAGSYDGNSRELRNGQMKAFLSLARFSDTQYQRIENYMKSSEFENKQTLLKRAKEEVGLLREHKIQTNRYTVKVQRELELDECALRALREDRKRFLCKAVENYINCLLSGEEHDLWVFRLCSLWLENSGVSEVNGMMKKDGMKISSYKFLPLMYQLAARMGTKMTGGLGFHEVLNNLISRISLDHPHHTLFIILALANANKDEFLSKPETTRRSRITKSTSKENSHLDEDRTEAATRIIHSIRSKRCKMVKDMEALCDAYIILANMDASQWRAQRKGINIPANQPITKLKNLEDVVVPTMEIKVDPTGEYENLVTIKSFKTEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYLVNSEDGAHRRYRPNDFSANQCQKKMMEVQKKSFEEKYDTFMTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRCCEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDESDLHSTPNADDQECKQSLSDTDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAMDPKNLSRLFPGWKAWV

Gene
ATM
Protein
Serine-protein kinase ATM
Organism
Sus scrofa
Length
3057 amino acids
Function
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
Similarity
Belongs to the PI3/PI4-kinase family. ATM subfamily.
Mass
350.564 kDa
Sequence
MSLALNDLLICCRQLEHDRATERRKAVENFRHLIQDPETVQHLDQHSDSKQGKYLNWDAAFRFLQKYIQKETECLRTAKQNVSASTQATRQKKMQEISSLVKYFIKCANKRAPRLKCQELLNYIMDTVRDSSNNPIYGADYSNILLKDILSVRKYWCEISQQQWRELFLIYFTLYLKPSQDINRLLVARIIQAVTKGCCSQTDGLNSEFLDFFTKAIQNARQEKSSPGLNHILAAYVIFLKTLAANFRIRVCELGDKILPTLLYIWTQHRLNDSLKEVIVELFQLQVYMHHPKGAKTQEKGAYESAKWKSILYNLYDLLVNEISRIGSRGKYSSGSRNIAVKENLIELMADICHQVFNEDTRSLEISQSYTTTQREFSDYNAPCKKRKIELGWGVIKDHLQKSQNDFDVVPWLQIATQLISKYPASLPNCELSPLLMILYQLLPQQRRGERTPYVLRCLMEVALCQGKKPNLESSHKSDLLKIWIKIWSITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACKPSCPTVCCLTLALKTCVVPETVETGMENICDGNRKFSLKESIMKWLLFCQLEDDFEDRIELPPILHSNFPHLALEKILVSLIMKNCKAAMNFFQSVPECEQHQKDTEEPSLLEVEELFLQTTFDKMDFLTVVQECTIEKHQSSVGFSFHQNLKESLDRYLLGLSEQLLNNYLPETSDSETLVRCSSLLVGVLGCYCYVGVIAEEEAYTSELFQKAKSLMQCAGESITLFKSKTNEESRIISLRNMMHLCTNCLYKCAKRSPNKIASGFFLRLLTSKLMHDIADVCRSLAFIIKKPFDCREVESMEDDTDKNLMEMNDQSSMSLFNDNPASSVIDANESGESQITMGAMNPLAEEHLSKQDLLVLDMLRFLCMCITIAQSNTMSFRAADIRRKLLMLIDSDRLDPTKSLHLHMYLVLLKELPGEEYPLPMEDVVELLKPLSSVCSLYRRDQDVCKTILNHVLHIVPNLCRENVDAESTRDAQGQFLTVIGAFWHLTKEGKCTFSVRLALVKCLKTLLEADPYSRWAILNVMEKDFPVNEVFPQFLADNHHQVCMLAAGLINRLFQHMKQGDSSTIMRALPLKLQQTAFENAYLKAQERIRQVKSQGGENRELLDEICNRKAVLLTMIAVVLCCSPVCEKQALFALCKSVKENGLEPHLIKKVLEKVSETFGYRHLEDFMASHLDYLVLEWLHLQDAEYSLSSFPFILLNYTNIEDFYRSCYKVLIPHLVMRCHFDEVKSIANQIQGDWKSLLTDCFPKILVNILPYFAYEDTGDRGMAQQRETASKVYDMLKDENLLGKQIDQLFINNLPEIVVELLMTLHEPATSDASQSTDPCDFSGDLDPRPNPPHFPSHVIKATFAYISNCHKTKLKSILEVLSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDMKSGLGGAWAFVLRDVIYTLIHYINKRPSRFMDVSLRSFSLCCDLLSRVCHTAVTYSKDALESHLHVIVGTLIPLVDGQMEVQKQVLDLLKYLVIDNKDNENLYVMIKLLDPFPDNAVFKDLRITQQEIKYSKGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLAQHKDQMMDLMRASQDNPQDGIVVKLVVSLLQLSKMAVNHTGEREVLEAVGRCLGEVGPIDFSTIAIQHSKDMPYTKALELFEDKEHHWTLMMLTYLNSTLVEDCVKVRSAAVTCLKSILATKTGHGFWEIFKTTADPMLTYLLPFRTSRKKFLEVPRLNKESPLEGLDDISLWIPQSENHDIWIKTLTCALLDSGGINSEVLQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRSLLSTHIQGFFTNCFRHSSQTSRSTTPANMDSESEHVFRCHLDKKSQRTMLAVVDYMRRQKRSSSGTVFDDAFWLELNYLEVAKVAQSCAAHFTALLYAEIYADKKNMDDQEKRSPTFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPLTRLRTYEHEAMWGKALVTYDLETAISSSTRQAGIIQALQNLGLCHILSVYLKGLDHENKEQCAELQELHYQVAWRNMQWDSCVSVNKGMEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEELCKGSLESVYSLYPTLSRLQAIGELENIGELFSRSVTDRQPSEVYNKWWKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMENSQRECLKDILTKHLVELSLLARTFQNTQLPERAIFQIKQYNSANCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCTENDPRLKLIHIECLRVCGTWLAETCLENPAVIMQTYLEKAVELAGNYDGESNDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTIKVQRELELDEGALRALKKDRKRFLCKAVENYINCLLSGEGHDMWIFRLCSLWLENSGVSEVNGMMKRDGMKIPSYKFLPLMYQLAARMGTKMMGGLGFHDVLNSLISRISVDHPHHTLFIILALANANKDEFLTKPEAARSSRITKNTPKESSQLDEDRTEAANKVICTLRNRRRQMVRSVEALCDAYIILANLDATQWRTQRKGIRIPADQPITKLKNLEDVVVPTMEIKVDPTGEYGNMVTIQSFKPEFRLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEYLVNNDTGAHKRYRPKDFSPVQCQKKMMEAQNKSFEEKYEIFMNICQNFQPVFRYFCMEKFLDPAVWFERRLAYTQSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDESELHSTPRADDQECKRNLSDTDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNFLIQQAMDPKNLSKLFSGWKAWV

Gene
ATM
Protein
Serine-protein kinase ATM
Organism
Homo sapiens
Length
3056 amino acids
Function
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C (PubMed:9843217, PubMed:9733515, PubMed:10550055, PubMed:10766245, PubMed:10839545, PubMed:10910365, PubMed:10802669, PubMed:10973490, PubMed:11375976, PubMed:12086603, PubMed:15456891, PubMed:19965871, PubMed:30612738). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response.
Similarity
Belongs to the PI3/PI4-kinase family. ATM subfamily.
Mass
350.687 kDa
Sequence
MSLVLNDLLICCRQLEHDRATERKKEVEKFKRLIRDPETIKHLDRHSDSKQGKYLNWDAVFRFLQKYIQKETECLRIAKPNVSASTQASRQKKMQEISSLVKYFIKCANRRAPRLKCQELLNYIMDTVKDSSNGAIYGADCSNILLKDILSVRKYWCEISQQQWLELFSVYFRLYLKPSQDVHRVLVARIIHAVTKGCCSQTDGLNSKFLDFFSKAIQCARQEKSSSGLNHILAALTIFLKTLAVNFRIRVCELGDEILPTLLYIWTQHRLNDSLKEVIIELFQLQIYIHHPKGAKTQEKGAYESTKWRSILYNLYDLLVNEISHIGSRGKYSSGFRNIAVKENLIELMADICHQVFNEDTRSLEISQSYTTTQRESSDYSVPCKRKKIELGWEVIKDHLQKSQNDFDLVPWLQIATQLISKYPASLPNCELSPLLMILSQLLPQQRHGERTPYVLRCLTEVALCQDKRSNLESSQKSDLLKLWNKIWCITFRGISSEQIQAENFGLLGAIIQGSLVEVDREFWKLFTGSACRPSCPAVCCLTLALTTSIVPGTVKMGIEQNMCEVNRSFSLKESIMKWLLFYQLEGDLENSTEVPPILHSNFPHLVLEKILVSLTMKNCKAAMNFFQSVPECEHHQKDKEELSFSEVEELFLQTTFDKMDFLTIVRECGIEKHQSSIGFSVHQNLKESLDRCLLGLSEQLLNNYSSEITNSETLVRCSRLLVGVLGCYCYMGVIAEEEAYKSELFQKAKSLMQCAGESITLFKNKTNEEFRIGSLRNMMQLCTRCLSNCTKKSPNKIASGFFLRLLTSKLMNDIADICKSLASFIKKPFDRGEVESMEDDTNGNLMEVEDQSSMNLFNDYPDSSVSDANEPGESQSTIGAINPLAEEYLSKQDLLFLDMLKFLCLCVTTAQTNTVSFRAADIRRKLLMLIDSSTLEPTKSLHLHMYLMLLKELPGEEYPLPMEDVLELLKPLSNVCSLYRRDQDVCKTILNHVLHVVKNLGQSNMDSENTRDAQGQFLTVIGAFWHLTKERKYIFSVRMALVNCLKTLLEADPYSKWAILNVMGKDFPVNEVFTQFLADNHHQVRMLAAESINRLFQDTKGDSSRLLKALPLKLQQTAFENAYLKAQEGMREMSHSAENPETLDEIYNRKSVLLTLIAVVLSCSPICEKQALFALCKSVKENGLEPHLVKKVLEKVSETFGYRRLEDFMASHLDYLVLEWLNLQDTEYNLSSFPFILLNYTNIEDFYRSCYKVLIPHLVIRSHFDEVKSIANQIQEDWKSLLTDCFPKILVNILPYFAYEGTRDSGMAQQRETATKVYDMLKSENLLGKQIDHLFISNLPEIVVELLMTLHEPANSSASQSTDLCDFSGDLDPAPNPPHFPSHVIKATFAYISNCHKTKLKSILEILSKSPDSYQKILLAICEQAAETNNVYKKHRILKIYHLFVSLLLKDIKSGLGGAWAFVLRDVIYTLIHYINQRPSCIMDVSLRSFSLCCDLLSQVCQTAVTYCKDALENHLHVIVGTLIPLVYEQVEVQKQVLDLLKYLVIDNKDNENLYITIKLLDPFPDHVVFKDLRITQQKIKYSRGPFSLLEEINHFLSVSVYDALPLTRLEGLKDLRRQLELHKDQMVDIMRASQDNPQDGIMVKLVVNLLQLSKMAINHTGEKEVLEAVGSCLGEVGPIDFSTIAIQHSKDASYTKALKLFEDKELQWTFIMLTYLNNTLVEDCVKVRSAAVTCLKNILATKTGHSFWEIYKMTTDPMLAYLQPFRTSRKKFLEVPRFDKENPFEGLDDINLWIPLSENHDIWIKTLTCAFLDSGGTKCEILQLLKPMCEVKTDFCQTVLPYLIHDILLQDTNESWRNLLSTHVQGFFTSCLRHFSQTSRSTTPANLDSESEHFFRCCLDKKSQRTMLAVVDYMRRQKRPSSGTIFNDAFWLDLNYLEVAKVAQSCAAHFTALLYAEIYADKKSMDDQEKRSLAFEEGSQSTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPITRLRTYEHEAMWGKALVTYDLETAIPSSTRQAGIIQALQNLGLCHILSVYLKGLDYENKDWCPELEELHYQAAWRNMQWDHCTSVSKEVEGTSYHESLYNALQSLRDREFSTFYESLKYARVKEVEEMCKRSLESVYSLYPTLSRLQAIGELESIGELFSRSVTHRQLSEVYIKWQKHSQLLKDSDFSFQEPIMALRTVILEILMEKEMDNSQRECIKDILTKHLVELSILARTFKNTQLPERAIFQIKQYNSVSCGVSEWQLEEAQVFWAKKEQSLALSILKQMIKKLDASCAANNPSLKLTYTECLRVCGNWLAETCLENPAVIMQTYLEKAVEVAGNYDGESSDELRNGKMKAFLSLARFSDTQYQRIENYMKSSEFENKQALLKRAKEEVGLLREHKIQTNRYTVKVQRELELDELALRALKEDRKRFLCKAVENYINCLLSGEEHDMWVFRLCSLWLENSGVSEVNGMMKRDGMKIPTYKFLPLMYQLAARMGTKMMGGLGFHEVLNNLISRISMDHPHHTLFIILALANANRDEFLTKPEVARRSRITKNVPKQSSQLDEDRTEAANRIICTIRSRRPQMVRSVEALCDAYIILANLDATQWKTQRKGINIPADQPITKLKNLEDVVVPTMEIKVDHTGEYGNLVTIQSFKAEFRLAGGVNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTVPIGEFLVNNEDGAHKRYRPNDFSAFQCQKKMMEVQKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDETELHPTLNADDQECKRNLSDIDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAIDPKNLSRLFPGWKAWV