Protein
DExH-box ATP-dependent RNA helicase DExH18, mitochondrial
Organism
Arabidopsis thaliana
Function
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates.
Similarity
Belongs to the DExH box helicase family.
Sequence
MARGVAGVLRRAYSSRVTVLFSTRNLHSFRESESRSLCNSDFDVPTNRFCSGNRVRIQFPWNDYRFGCFEIGKVRSFSSTVDNNGENDDIEESVGSESDDYDEEGLINELSDVDEGLLNDSVVAETDEIGSEAARALNDRYHDPVELYRELRGSEVRSKLQHSEWDSLHEIFGFFAQSGWAANQALAIYIGKSFFPTAVSKFRDFFIEKCGIEVVQDLVRVGPTDVAVKFLFPVFVEFCIEEFPDEIKRFKSIVDTADLTKPATWFPFARAMKRKIVYHCGPTNSGKTYNALQRFMEAKNGLYCSPLRLLAMEVFDKVNALGIYCSLLTGQEKKYVPFANHVSCTVEMVSTDELYEVAVLDEIQMMADPSRGHAWTKALLGLKADEIHLCGDPSVLDIVRKMCADTGDELVEEHYERFKPLVVEAKTLLGELKNVKSGDCVVAFSRREIFEVKMAIEKHTNHRCCVIYGALPPETRRQQAKLFNDQENEYDVLVASDAVGMGLNLNIRRVVFYSLNKYNGDKIVPVAASQVKQIAGRAGRRGSRYPDGLTTTLHLEDLNYLIECLQQPFDEVTKVGLFPFFEQIELFAAQVPDMAFSNLLEHFGKHCRLDGSYFLCRHDHVKKVANMLEKVEGLSLEDRFNFCFAPVNIRNPRAMHNLYRFASSYSQNMPVNVAMGIPKSSAKSDAQLLDLESRHQILSMYLWLSNQFEENFPFVEKVEAMATNIAELLGESLSKASWKMESKEEKVKGQMKEDRGYERPASLIKLVKKRKDEKLV