Protein
Lipoyl synthase, mitochondrial
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Sequence
MAAASTNRLRLLYTSTRASLPQSTPSILTTRTYATTDSSTSATSTPKPRRRTAFTDKLNAGPSFGDFVSGNNDNAPLIDPSEAYALETALVGPAGRKKQMTRLPPWLKTPIPDSKNYQRLKKDLRGLNLHTVCEEARCPNISDCWGGGDKAAATATIMLMGDTCTRGCSFCSVKTSRRPAALDPHEPENTAEAISRWGLGYVVLTSVDRDDLADGGARHFAETVRKIKSKAPSTLVECLTGDYRGDLDMVALVANSGLDVYAHNIETVEALTPRVRDRRATFKQSIAVLEAAKKANPEVITKSSLMLGLGETEEQLEHALAQLRAVDVDVVTFGQYMRPTKRHMAVHEYVHPRWFEHWQRRAEELGFLYCASGPLVRSSYKAGEAFIENVLKKRRAGVSDAVAEKKVAAAVDEAAR