Protein
Bifunctional lycopene cyclase/phytoene synthase
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Function
Bifunctional enzyme that catalyzes the reactions from geranylgeranyl diphosphate to phytoene (phytoene synthase) and lycopene to beta-carotene via the intermediate gamma-carotene (lycopene cyclase).
Similarity
In the C-terminal section; belongs to the phytoene/squalene synthase family.
Sequence
MNQNGTRLCYSVREVPPTSFVSAPANYKRASSHCTYTIPAASALTVLYYPFFTAQDRCKICILITIAILATLPWDSYLIRSAIWTYPPDAVVGLKILDIPIEEVFFFAIQTYITSLTYCIFTKPLVRPMYLRSHLERRGTRYVVATVILALMGGGTACLLLGRRMTYLGLILVWACPILLFQWMMSYPFLSELPWKPTITSICLPTLHLWFADSRAMGTGTWRIEEGTKLNFRIGGLELEEALFFLVSNMMVVLGLVGCDYAYALQEYESLSQPASDVYITLRKALSLLARPLPIDASLISALSQAVYRLQEKSQSMFLGSALFQGQLRIDLIFLYSFCRVMDDLIDEAEDEQEARFWVTECRHLLDSTHRSEPHSDHFYTGKKGEEHERLRQSISYLPPSHLSNDSFDDLLKGFEIDLKFNPQREAFPIQSEYCLDQYAGFVAGTVGVLVFDLTLFHCGHYFIQDVPRLRRAAKDMGKAMQCQPRGDGGATSGRKRAIAGNRGELYGYWTTAEGAERHKPGASVEDEGAFGATAKSWLAGDVITELCHCFIQAEYVIYLVRHQNASADTLVLLSALVYRLE