Protein
Xanthine dehydrogenase
Organism
Blastobotrys adeninivorans
Function
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Oxidizes xanthine, hypoxanthine and pterine at high rates. Can also act on purine and guanine.
Similarity
Belongs to the xanthine dehydrogenase family.
Sequence
MVDLQLHQSLGHHNFTNKLTFYVNGVKRTISNPDPRGTLLDFIRTHEGLTGTKLGCSEGGCGACTVVVASWDREQGEIIYSAVNSCIVPLVAVEGKHLITVEGIGSSNNPHPAQERIALFHGSQCGFCTPGIVMSLYALLRNTGGQPSKEQIAESFDGNLCRCTGYKPIIDAANTFSCGRPGGCCRDNASGKANGAGATVGNGMANGAAAVANGNGAAANGCCKGNGAANGCCKSNGSAATTANGDDKEVDMNKLFTPNGLPLKPYSAKTELIFPPALKKYELNPLFFGNEQKVWFRPVTKLQLLQIKHAYPESKIVGGASEIQIEIKMKAANYNISVYANDIEELKTHKYIPGKGLEFGANISLSKLEEVCDKLVHELDPNVSQIYGAILEQLKYFAGRQIRNAATPAGNIATASPISDLNPVLVAAEAVLTVESIENGEEQISMTDFFVGYRKTKLPAHGVITKIFVPETVPRNEVVMAYKQAKRKDDDIAIVTACLRLALDDDFRISKARLAYGGVGPFTTAAKGTAEFLTGKLLRRETAKEVLEGAIDCLIKEFDLPYSVPGGMAAYRRTLIMSFFYKFYSTVLEKIGLAGEAQDNSALENTYDPQALLEVTRKHPVGSRDLTNPYEQRIVGKSDPHLSALKQVTGEAVYIDDIPPYHGECFGVQVMSTKPRARILSVDPSPALEVEGVVGYVDVNDLPSREANIWGPTPVGKEPFFADGEVYYVGQCIGVIIATDRMIAEEAARLVKVEYEELETVITIEEAIEAQSFFDYQPKAEKGDVDGAFAESAYTFEGTSRIGSQEHFYLETQGSLVVPEPEDGEMKVYSSSQNPTETQVFVAQATGVPSSRIVARVKRLGGGFGGKESRCCHLSSIAAVAAKKYKRPVRMILSRSEDMLTAGQRHPFVMKWKVGLDKNYKFTALEAKLYANAGWSMDLTKGVIERAVLHAENCYDFPNARIQGIPCRTSVASNTAFRGFGGPQGMFMAECYIYEIADQLGIEPDTLREINYLVPGVSSTPFKQAITEDFTVPDMVKQIKKQSNYDDLRRQVEEFNSKHKWIKRGLAHVPTMFGISFGATFLNQAGALVHIYHDGSILLTHGGTEMGQGLHTKMAMVCAEELKVPLSQVFISETSTNTVPNTSASAASASSDLNGMAVKHACDQLNERLAPYRERLGENATMEQLAHAAYFDRVNLSANGFYKTPDIGFVWGDPNPKPAFFYFTQGCAVAMVEVNTLTGDWSNLRTDIVMDIGRPINQAIDYGQIEGAFVQGQGLFTIEESLWLRNGALFTRGPGAYKIPGFRDIPQEFNVGHLRDRPFKHLKTIHRSKGIGEPPLFLGSSVFFAIRDALSYARRQNLGEATMPAGLVAPMTTERIRMLAGDSLYEHKGKIEPTEGDDKPFFVNA