Protein
Histone-lysine N-methyltransferase ATXR3
Organism
Arabidopsis thaliana
Function
Histone methyltransferase specifically required for trimethylation of 'Lys-4' of histone H3 (H3K4me3) and is crucial for both sporophyte and gametophyte development (PubMed:21037105, PubMed:20937886).
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.
Sequence
MSDGGVACMPLLNIMEKLPIVEKTTLCGGNESKTAATTENGHTSIATKVPESQPANKPSASSQPVKKKRIVKVIRKVVKRRPKQPQKQADEQLKDQPPSQVVQLPAESQLQIKEQDKKSEFKGGTSGVKEVENGGDSGFKDEVEEGELGTLKLHEDLENGEISPVKSLQKSEIEKGEIVGESWKKDEPTKGEFSHLKYHKGYVERRDFSADKNWKGGKEEREFRSWRDPSDEIEKGEFIPDRWQKMDTGKDDHSYIRSRRNGVDREKTWKYEYEYERTPPGGRFVNEDIYHQREFRSGLDRTTRISSKIVIEENLHKNEYNNSSNFVKEYSSTGNRLKRHGAEPDSIERKHSYADYGDYGSSKCRKLSDDCSRSLHSDHYSQHSAERLYRDSYPSKNSSLEKYPRKHQDASFPAKAFSDKHGHSPSRSDWSPHDRSRYHENRDRSPYARERSPYIFEKSSHARKRSPRDRRHHDYRRSPSYSEWSPHDRSRPSDRRDYIPNFMEDTQSDRNRRNGHREISRKSGVRERRDCQTGTELEIKHKYKESNGKESTSSSKELQGKNILYNNSLLVEKNSVCDSSKIPVPCATGKEPVQVGEAPTEELPSMEVDMDICDTPPHEPMASDSSLGKWFYLDYYGTEHGPARLSDLKALMEQGILFSDHMIKHSDNNRWLVNPPEAPGNLLEDIADTTEAVCIEQGAGDSLPELVSVRTLPDGKEIFVENREDFQIDMRVENLLDGRTITPGREFETLGEALKVNVEFEETRRCVTSEGVVGMFRPMKRAIEEFKSDDAYGSESDEIGSWFSGRWSCKGGDWIRQDEASQDRYYKKKIVLNDGFPLCLMQKSGHEDPRWHHKDDLYYPLSSSRLELPLWAFSVVDERNQTRGVKASLLSVVRLNSLVVNDQVPPIPDPRAKVRSKERCPSRPARPSPASSDSKRESVESHSQSTASTGQDSQGLWKTDTSVNTPRDRLCTVDDLQLHIGDWFYTDGAGQEQGPLSFSELQKLVEKGFIKSHSSVFRKSDKIWVPVTSITKSPETIAMLRGKTPALPSACQGLVVSETQDFKYSEMDTSLNSFHGVHPQFLGYFRGKLHQLVMKTFKSRDFSAAINDVVDSWIHARQPKKESEKYMYQSSELNSCYTKRARLMAGESGEDSEMEDTQMFQKDELTFEDLCGDLTFNIEGNRSAGTVGIYWGLLDGHALARVFHMLRYDVKSLAFASMTCRHWKATINSYKDISRQVDLSSLGPSCTDSRLRSIMNTYNKEKIDSIILVGCTNVTASMLEEILRLHPRISSVDITGCSQFGDLTVNYKNVSWLRCQNTRSGELHSRIRSLKQTTDVAKSKGLGGDTDDFGNLKDYFDRVEKRDSANQLFRRSLYKRSKLYDARRSSAILSRDARIRRWAIKKSEHGYKRVEEFLASSLRGIMKQNTFDFFALKVSQIEEKMKNGYYVSHGLRSVKEDISRMCREAIKDELMKSWQDGSGLSSATKYNKKLSKTVAEKKYMSRTSDTFGVNGASDYGEYASDREIKRRLSKLNRKSFSSESDTSSELSDNGKSDNYSSASASESESDIRSEGRSQDLRIEKYFTADDSFDSVTEEREWGARMTKASLVPPVTRKYEVIEKYAIVADEEEVQRKMRVSLPEDYGEKLNAQRNGIEELDMELPEVKEYKPRKLLGDEVLEQEVYGIDPYTHNLLLDSMPGELDWSLQDKHSFIEDVVLRTLNRQVRLFTGSGSTPMVFPLRPVIEELKESAREECDIRTMKMCQGVLKEIESRSDDKYVSYRKGLGVVCNKEGGFGEEDFVVEFLGEVYPVWKWFEKQDGIRSLQENKTDPAPEFYNIYLERPKGDADGYDLVVVDAMHMANYASRICHSCRPNCEAKVTAVDGHYQIGIYSVRAIEYGEEITFDYNSVTESKEEYEASVCLCGSQVCRGSYLNLTGEGAFQKVLKDWHGLLERHRLMLEACVLNSVSEEDYLELGRAGLGSCLLGGLPDWMIAYSARLVRFINFERTKLPEEILKHNLEEKRKYFSDIHLDVEKSDAEVQAEGVYNQRLQNLAVTLDKVRYVMRHVFGDPKNAPPPLERLTPEETVSFVWNGDGSLVDELLQSLSPHLEEGPLNELRSKIHGHDPSGSADVLKELQRSLLWLRDEIRDLPCTYKCRNDAAADLIHIYAYTKCFFKVREYQSFISSPVHISPLDLGAKYADKLGESIKEYRKTYGENYCLGQLIYWYNQTNTDPDLTLVKATRGCLSLPDVASFYAKAQKPSKHRVYGPKTVKTMVSQMSKQPQRPWPKDKIWTFKSTPRVFGSPMFDAVLNNSSSLDRELLQWLRNRRHVFQATWDS