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ATG21

Gene
ATG21
Protein
Autophagy-related protein 21
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
532 amino acids
Function
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).
Similarity
Belongs to the WD repeat SVP1 family.
Mass
60.219 kDa
Sequence
MVIINNLTFNQDYSCVSVSTTKYHKIFNCDPFGEFYSSYQGSSGTKGDKPNDNDKEIIIDKGNGNEYNKIGEDSPTSYLKMLFSTSLTIIIPQNESVGNRLLKIYNLKQNMKICELTFPSHIIDVKLNRKRLCVILESGQIYIYDLSCVRLIKVLEISSFSSKDSEEETHQKLFVGDLGAEDKSLLVLPISNITDQTDLFNTENGVNVTRASDSNILTSLKPLIEFTENKIDKDIITLEDLQKDSNGWVLIYDTIKLKPRLIYKAHDSSLAKITISNDNKKIATASSKGTIIRVCHLESSDDEDVSKPFNISQIINLRRGHNIAKVNCLSFSLDNSILGCGSESNTIHFFRLSKQPHESFEYEEDPANESDPDDEDRSSEDLNQNLANLLISKTPDASAPDQKDSAKSSYFGVLKKKVEGSSRFMNNPYTQTIVRNLPYKNYFENLIWEPPRRAFAYVKLPEYTPPQLFNLHQSKNKVAIGFANTNNNGHLIMLASYQTGQFYHYQLPKPSDQPEPSDSRHECNLIAQYSLL
Protein
Autophagy-related protein 21: ATG21

Gene
ATG21
Protein
Autophagy-related protein 21
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
529 amino acids
Function
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).
Similarity
Belongs to the WD repeat SVP1 family.
Mass
60.019 kDa
Sequence
MVTINDLSFNPDYSSISVSTSDGFKIFNCEPFGEFYSSQESPLRKSISNSLEDSAGCQNPTHSKTDSQDTPARFPTAFLKMLFSTSLTIVVPQTQDNLGNRLLKIYNLKQNLKICELNFPSSIIDIKLNRKRLLVVLDTGQLYIYDLSCVRLLKILQLSFNEHDGDQKFIGDLSADDSSWLIIPVQSTNNQTDLLNAETGSQPSTPKLTPSDSVINTGSYSQYLEFTRNSSLSNLKKKNKLITLEDIKNDSEGWVVVYDTINLAPVVIFEAHHSTIARICISHRDNKVATASIKGTIIRIFDLKEFEGKVKVHKVKNLRRGHNLVKVNSLSFHNDNHILGCGSESNTIHLFKIHEEESDICTNENSEDRTNHNSDYEDSDGDTSKSSEDLNENLANLLISKPLDPVPMETEDKLSSSWFVKTKKLINNQYTSSIIKKLPYKDYFENLIWEPPQRSFAYIKLPEYAPHNEKDPRSNKVEIGFNNDLVFIASYHTGNFYQYQIPKQRGPVSSINEDDKREECSLISQFNLI
Protein
Autophagy-related protein 21: ATG21

Gene
ATG21
Protein
Autophagy-related protein 21
Organism
Saccharomyces cerevisiae (strain YJM789)
Length
496 amino acids
Function
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage. Essential for maturation of proaminopeptidase I (By similarity).
Similarity
Belongs to the WD repeat SVP1 family.
Mass
55.138 kDa
Sequence
MKVLQFNQDATCCVVAASSHQISIFNCDPFGKCFEIDTKNSKKKTSNNNGTASNSESRNNEESILITNGSRDRTDAEEEEDNEDNALVTGNILKEGEFVIEMLFSTSLIAIADRGQGLNKGKKLKIVNTKRKSTICEIVFPHEIVDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYKRSQANSFSNASNTGTLEGDSANLNRVATNLLANATQKSVNGSNPSVRTRRNSLRSKIRPRMVLSNDDRSILCFTAYSSPKKNKPNSEALYDVVIYDTLNVTPVNYLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRGTRLCNLYQLAFDKSMTMIGCVGDTDTIHLFKLDDASNSLPGDNSSNGHWNEEEDILASNSNPSMGTPKEIPLSKPRIANYFSKKIKSSIPNQNLSRNFAYITVNESNRSCLGFPDEFPNQVYIASDDGTFSIYSIPSKPGECVLTKNNKFT
Protein
Autophagy-related protein 21: ATG21

Gene
ATG21
Protein
Autophagy-related protein 21
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
496 amino acids
Function
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage. Essential for maturation of proaminopeptidase I.
Similarity
Belongs to the WD repeat SVP1 family.
Mass
55.188 kDa
Sequence
MKVLQFNQDATCCVVAASSHQISIFNCDPFGKCFEIDTKNSKKKTSNNNGSASNSESRNNEESILITNGSRDRTDAEEEEDNEDNALVTGNILKEGEFVIEMLFSTSLIAIADRGQGLNKGKKLKIVNTKRKCTICEIVFPHEIVDVVMNRKRMCVLLESDQIFIYDISCMKPLETIDLWEDHYKRSQANSFSNASNTGTLEGDSANLNRVATNLLANATQKSVNGSNPSVRTRRNSLRSKIRPRMVLSNDDRSILCFTAYSSPKKNKPNSEALYDVVIYDTLNVTPVNYLNSVHKGNVACLAVSHDGKLLATASDKGTIIRVFHTGVDSDYMSSRSLFKEFRRGTRLCNLYQLAFDKSMTMIGCVGDTDTIHLFKLDDASNSLPGDNSSNGHWNEEEYILASNSNPSMGTPKEIPLSKPRIANYFSKKIKSSIPNQNLSRNFAYITVNESNRSCLGFPDEFPNQVYIASDDGTFSIYSIPSKPGECVLTKNNKFT
Protein
Autophagy-related protein 21: ATG21

Gene
ATG21
Protein
Autophagy-related protein 21
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
453 amino acids
Function
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).
Similarity
Belongs to the WD repeat SVP1 family.
Mass
50.374 kDa
Sequence
MKVLRFNQDASCCVVNSGANELTVYNCDPFGKCFEFNISNVNGDSNDNGIGYDSLEAGSSSIESQVIAEMLFSTSLLAVVDKGQGINTGKKLKIVNIKKRSLICEIAFPSLIVDVVMNRKRICVLLDNDQIFIYDISCMKLMETLDLWESNNEGNLNDHIKVGERASNMINENLKNGNELDRIRSKSNNNNDQTNSDNGRSRTYSINGSHKIKPQLTLSGNDNSILCYSKYSSSKQNPARILNDIVVYDALNLKPINYLNSVHKGCVLKTSVSIDGKLLATASEKGTIIRIHKTGVDSDFASGPLLYKEFRRGSRPSHIHQLLFNKDSTLLVCVGDSDTIHIFRTDDDGLALDGIDGDIGSDSGGSLELIKNRIPHEQVKKFFSRKIKSHIPNQNLHRDFAHINMDRIVHTVVGFPEEFDNKIYVASDDGSFKTYTIPSKHGQCVLNKTSHFI
Protein
Autophagy-related protein 21: ATG21

Gene
ATG21
Protein
Autophagy-related protein 21
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Length
422 amino acids
Function
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).
Similarity
Belongs to the WD repeat SVP1 family.
Mass
46.848 kDa
Sequence
MGLSRFNQDATCFVTSSEGNSVTIYNCDPFGKCFEMVDEDTQNIGDDDARGDDNSGGDDDLLVEMLFSTNLVAIVHRKQGILKSKKLKIVNIKRKTIICELSFPHPIQDVVMNRKRVCVLLNSDQIHIYDISCMKHLHTIDIWDSQVKSITGQGVDSLSNSGTSNMTSLRERSSTFSKSISPKICLSNDDRSILAFNCYSTSSKSVILNDVVIFDALNISPLNYINSVHKGNVASLAISPDGKFIATASEKGTLVRIFNTGAETESELLTPLLYEFRRGNRPCNINQLTFNSDSTLLGCVGDSDTIHIFKLDSTSRLLSMSVNSEDNSHITSEDIKALRKDPNSKQFTKLISKTIKKSIPSQALRRDFAHITIKNTKTKHILGFPKEFMNQVYVLSNDGSFFIYSLPSTSGSCVLSKQNDFK
Protein
Autophagy-related protein 21: ATG21

Gene
ATG21
Protein
Autophagy-related protein 21
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
409 amino acids
Function
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).
Similarity
Belongs to the WD repeat SVP1 family.
Mass
46 kDa
Sequence
MKVLRFNQDASCFSAVSRPHSMTIYNCDPFGKCFELENSVVTSESCDTECLTKAQGDQCSNFVTEMLFATSLIAVVNRDQGLQKARKLRIVNTKRKTTICELTFPHEVVDIVMNRKRMCVLLSSDQIFIYDISCMKLLQTISVLEDKLKMAVSDQGHVSTSVVGRQLQGETSMVRIALCSDDKSILCYTAYCRTNKNSYILNDLVVYDALNMTPLNYLNTVHKGNVACLCISNDGKMVATASDKGTIVRIFSTGDENTLQSGNTLLHEFRRGTRPCSIYEMKIDPTRRYLACVGHTDTIHIFDLERQGQQNKSLSDSQSTALLREGKLSKESTLQFASFLSKKVISKIPNQNMERHFAHIKVDDSVRHCLGFPDEFSDRVYVASNNGEFQVWNIPQSGGECILVKKSKF
Protein
Autophagy-related protein 21: ATG21

Gene
ATG21
Protein
Autophagy-related protein 21
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
392 amino acids
Function
Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).
Similarity
Belongs to the WD repeat SVP1 family.
Mass
43.555 kDa
Sequence
MALKLLGFNQDATCFSVISSNKGVTIYNCDPFGKCFELEKSTSNDEELDFLVEMLFSTSLIAVVDKTIGASKRKKLKIVNTKRKATICELTFPHEIMDVIMNRKIICVVLKSDQIFVYDISCMKLLRTIDVRGEKLKSTSKFRNSEAVGDIGVRVSLSTDNNSILCYSSYSKSDKENAPLNDIVVFDALKCIQINVLPAVHQSNIVCIACSPDGMLMATASEKGTIIRVFKTIDTENDEPILVNEFRRGSRPSRISEMKFNHDNTLLACVGESDTIHIFALPVTTTEADANEDDTLQQSSHSLSSSINGLQYISKGLANRFGKIIVSKIPTQSQQRHVAYIKIPENAKYRIGFPKDTTNTIHICGEDGNYLVYSIPRNEVGPCTLVKSNTFD
Protein
Autophagy-related protein 21: ATG21

Gene
ATG21
Protein
Autophagy-related protein 21
Organism
Pichia angusta
Length
388 amino acids
Function
Involved in peroxisome sequestration to the vacuole during macropexophagy. Also required for microautophagy.
Similarity
Belongs to the WD repeat SVP1 family.
Mass
42.854 kDa
Sequence
MALRSISFNQDYTCLAAGFDAAYKVYNCDPFGECFQKADDGGANLVEMLFSTSLIAVVGIGDKPANTMRKLKIINTKRKAVICELTFPTAILYVKMNRKRLVVVLVDQIFVYDVSCMKLLHSIEASAGLDDRIICDLCADDESVLVFQQSGSSDELAANAGTVVVFDALQIQPINVIECHRSPLQRIAVSKDGRLLATASVKGTIVRVFRVADGRKVHEFRRGSYTAQISCLSFNVDATVLCCSSNTGTVHFFRLDDVDRRRSTGSIDANIDGSETLPRESSITEEESSEINRLINSQLGGHNGFAKKKSAESLKNFIWSKSKTYLPSQINSILEPKRDYAFIKLTTEVESVVGLVDNNCYVATRAGDFFVYSVQPGQCVLLKHYKIE
Protein
Autophagy-related protein 21: ATG21