ATG13

Autophagy-related protein 13

980 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

105.385 kDa

MHQHRRTSSAVASPVSSPHPSSSRPITRDRGTARFGPNVSRGLGIDRQMDASDQEQTIESPEKSPSQKLDQIIQNYHTKAALVILHSRVDLSPATYHGVIRTNKWFNVEVNETEDLKDSLGVWKYSNCTDSRPPPLIIEVYLDLTQLTNNQSLVIIDDSGKRWDVVEALATYGCLDNSRTSKSGVILERWRIDLGPGPDDLPLDMGSILPTVYKKSIVVFRSLYAYSKLLPAWKYSKRHSKIRPNPALSLKYRILQGPGGQIRSTNDPLTVPLHPGNGPVVDTYSFGVTDSPAGPLSALVTYRTNCDFRVDDSEALLSSRFMGVDERFFKPSLPSEDNFAAAGQEHGSLPVQKRDVGRPDLGQAYGSMSTFHQVGATTGASPISALRAARELAAGSPSSPTRPSHSPRPSQAGRVAALSGEGNHLIQRRPSISIQPFKAPPLSASPALVDSPVGSQPKNSAPRVGPMDITSSARQMPPPHGTPTTSRRSAHVSESAIASSTSGSPRPAPISKYSSSFSHRRGRLSSGGASKTDDDNNSSGRVSVSSSTVHPGSGTSADPATTSSGSLQADEDNISDFLKMLEMGKDLLSRKDSKSLDKNTKRTSAALSRFQKMRDSNAVLSDSMSSSLLLQPSSISSSKQLPNAATSVAGASISVSSSPGKAISPHTQHIPAVPSRLSSNSVVDYSHSHEDRHERRHRLSHESRRSPSEERANDEPRLKRDESTANAIDIPTSPRPFIPSFRRSSSAAQRRSSPPVEDDLGDFLPFGMRSLSLGAEDRSTLSLSELVRQQESSVPASDTNALQQQNQKDTRTGQSIVDESPSRIDNVPGTSSPRQYQPRFAHGRGRGSFGHPQPHVSAASSLGRASPIPNVTDADREGYIGSGNNGGTAVPPDTRRGSSHRFSFNRHLGTPANMDEDEPLLFAMSDFGASRRSLEEGRKGATTAGADHGGAPSTELQPAAETRSEGGPPSVSRGRYRAWP

atg13

Autophagy-related protein 13

974 amino acids

Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, atg13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

103.872 kDa

MHQQPRSPAPAASTSSARRSQDYDRRSDSPAFDLRTHTNRGLGIETENDTAEPEQSSQPGPEAISKVNQIVTNYHTKAALIILHSRVELPPSYAKNSNVPRVNRWFNVELEETDALKDQLKTWRTCDATDNRPPPMIIETYLDTAGLTNNQTLVALDDNGKRWDVTESLAASQSSRPAKASSSRAVDVILERWRVELGDMPGKLPSDLGAILPTVYKKSIILFRSLFTYSKFLPAWKFIKRNGRSRAHPALRVKYRIFSGHARDLSKQDHLTMPLFEGDTKVVDTYSFGVTDSPAGPFSVQVTYRTCCDFRVDDSEALLSSQFMGADDEIFQPSLPSGGLDARVTPEVGSAPLTRRTVEDPDLSRAYGSLSTFHHVGPTTGASPISALRAAREARASSPSPPTSSHRNSFAAARASPVGRAATLANDTNPNVARRPSISFQPFKAPPLSASPSLVDPPLSASPRTTGAGRTSLSDSRHMPPPSVTTSSRKPPSFGPDNANSSPNSASPRPTPMSRYSSAFSHRRGRPSSGGINKLEDDNSSGRASATSSGAQPGSGLLAEITGTSSDSIHADDENISEFLKMLDLRKDLLSPSSQTAMDNHSRRMTAASAALSRFRGMKDSNAALSDSMSSSLLMNRSSATSSKQLSGVPGIAGTSISTASSPGGKAISPHTPHTPAIPSRLSSNSIVDNTTTRLHGDNGSPVEEDASDETTTERLPSTVTAIPIPTSPATIFPSTFRRSSSAANRRSSHAIDDDEIFTMRSVSLGAEEPSHTTLGALQRQQDYEPIGTNIAPLESGARSSGGDDGNVLRGPTRRGPGAHRDASLSGPTVATSPYSHHPLHQRRISHSRGRGFSGGPHSLSSGSSSIARGGLIHPYPAEREAERDANAGASHSGTEDRRGTGRGSGGGRHNLPQAAQVEEDEPLLFAMSDFGASRRSFEEGRQGNHGPDSSGNTGSSRRGSGKRGTLSGFHLWP

atg13

Autophagy-related protein 13

974 amino acids

Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, atg13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

104.03 kDa

MHQHPRSSVPSPAPNFPPRPTARDDRREQEAAPSSPTVDMGSNSARGLGIEPGPQPSEQGRNAALGREALTRLNQIISNYHTKAALIILHSRVALPPSFNKGSESPRVNRWFNVELDDTDVLREPLRPWRTCDATDNRPPPLVIETYLDTKGLTNNQSLVILDENGKRWDVRESLAALQGARAKPYQSENDEIILERWRIELGESSSRLPADLGSILPTVYKKSIVLFRSLFTYSKFLPAWRFSKRNKKLRQSPALQIKYRVVDGSVARDDLSLDHLTAPLSEGSEKVVDTYSFGVTESPAGPFSVQVTYRTNCDFRVDDSEALLSSRFMGADDEIFRPSLPSDDVNRPNPEIGSVPVERKAVENPDCTRAYGSLSTFHQVGPTTGASPISTLRAMRDSGAGSPSPTDSPKRLLPPAKVVPSGRAGQIAGEGGSSNFQRRPSVSFQPFKAPPLSASPALADSPLGMSPRNMSSRIPTGTSADSRVMPPPSSAASARRPTTIASEQAISSSNSASPKPAPISRYSSSFSHRRGRLSAGANRLEDDNSSGRASATSSNAQPGSGLLTEATGTSAESIQADDENISEFLKMLDSKKDLMNSSTSASIQPGPSTTAAALARFRGMRDSNAALSDSMSQSMHMHRSSISSSKQLSGVPPMVAGTSISTASSPGKPMSPHTPHTPHTPAIRSRLSSNSVADDIETDHHSRLPRIHHDPPLEEHSSAENTRAPSSTAGAIDIPTSPRIFNPAYRRSSSAAVRRPIVTSDDDEIFPFGIRSLSLGADESANATLGATQQQNESQKDQQSPAEDRSGPSVSTTGPYRDSASLRGQMSGPTSASASSNPHVYQPRFASSRGRGYSGGHSLSSASSSLARGANLTPHLAERDQDRDGNASGSNSGNSTLEIRRGSGQRPSTGRTLSGQAPEDDEPLLFAMSDFGASRRSLDEGRHGNHGGTESAAGSRRGSGRRGAGLPGFHVWS

atg13

Autophagy-related protein 13

974 amino acids

Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, atg13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

103.814 kDa

MHQHPRSPAPTAPTSSARPNSSRSRELDYRPNSPAADVRVHNSRGLGIETEPDSSGQTVQPAKEAIAKLNQIISNYHTKAALIILHSRIELPPSFNKGSDTPRVNRWFNVEIEDTDVLREQLRTWRTCDATENRPPPLIIETYLDTKGLTNNQTLVALDENGKRWDVLEALAASQQAHPVRPPSASSDDVILERWRVELGDTSNALPADLGSILPTVYKKSIVLFRSLFTYSKFLPAWKFAKRNGRLRANPALRIKYRIIIGSPNQVSSKPDHLTMPLYESSSKVVETYSFGVTDSPAGPFSAQVTYRTSCDFRVDDSEALLSSRFMGADDEIFRPSLPTRVVDSKVPPPEIGSLPQERRTIEDPDPGRAYGSLSTFHQVGPTTSASPISALRAKGKLGTSSPSSPGSSSRKALAVAKASPVGRAAALASEGSPGVVRRPSISFQPFKAPPLSASPSLVDPPLSSPRSVSGPRPHPPMAASARKSFPAVQDNSIASPSSASPRPSSISRYSSAFSHRRGRPSSGGINKLEDDTSSGKASATSSAQPGSGLLAEPTGTSADSIHADDENISEFLKMLDLRKDLLNTSGSAALDATARRTTVTSAALTRFQRMRDSNAALSDSMSSSLLLQRSSNSSSKQLSGVPPMVAGTSISTASSPGKPISPHTPHTPAIPSRLSSNSIVDYTHSEGNGTELSQGHGSPLDENTSDGTTMEHGPSAVNAIDIPTSPRLFPPVYRRSSSAAHRPRTVAVDDDEIFPFNRSVSLGAEERSNLSLGALHRQHEYESSDTATHRAQREPRPMSSNEDAVVPPSSITRGQGSHKGVTPGPTVASSSSSHHHVYQPRFSHSRGRGSSGGHHSLSSGSSSLARGAAITPGLAERESERDGNGSGSNSVTSAMEDRRGVGRRPSAGRGGPPQSAQLEEDEPLLFAMSDFGASRRSFEEGKHVNHAHDPTGNIAGSRRGGSSRRGGGFHAWS

atg13

Autophagy-related protein 13

958 amino acids

Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, atg13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

102.702 kDa

MHQHPRSPAPAAPTSSTRSNRSTDHRELDTDPSSPSSDVRMHNGRGLGIEPETEPSEQVQRNTQPAKEAMAKLNQIITFNVEIEDTDILREQLRIWRTCDAIENRPPPLIIETYLETKGLTNNQSLVILDENGKRWDVLEALTASGQASPVRPPHSNSDDVILERWRVELGSASSKPPSDLGSILPTVYKKSIVLFRSLFTYSKFLPAWKFAKRNGRLRSNPALQIRYRILDGRTASDRRQVDHLTVPLYEGNTKVVETYSFGVTDSPAGPFSVEVTYRTNCDFRVDDSEALLSSRFMGADDEIFRPSFPSRDANRRASNAEPGSAPLEKRTVEEPDPGRAYGSLSTFHHVGPATGASPISALRAARESVTSSPSPPSSASRRPLSAARAAPTGRAAALAAEASPSPLRRPSISFQPFKAPPLSASPSLIDPPLGASPRSRPIVSAPSSEPKHMPPPSVAASGRKTGQAASENAIASSNSASPRPAPIARYSSAFSHRRGRPSSGGINKIEDDASSGKASATSSGAQPGSGLLAEVTGTSADSLHADDENISEFLKMLDLRKDLLSPSNLSNLDAVARRTTVTSAALTRFQRMRDSNAALSESMSSSLLLQRSSNASSKQLSGVPPMVAGASVSTASSPGKPISPHTPHTPAIPSRLSSNSIVDYNDHGHSDGRLLHGGPTSLPEDTTGEETALVHRPPTVTAIDIPTSPRLFPPTYRRSSSAAQNRRSVVADEEEIFPFNMRSVSLGAEERTNVSLSTLHRRHEYHNAATNPEQQQESQRASSSSDQGPTALPSPAKRETRSQGDATVSGQTPELSSSANHNLYQPRLGQFRSRGSFGGAHSLSSGSSSLARGGGIPTYLTERDNDRDGNASGSNSGNSTTEERRGFGRRVSAGRNYPPHPSQVEEDEPLLFAMSDFGASRRSFEEGRQGNHGADFGGSRRGSGRRGAGVPGFHVWS

atg13

Autophagy-related protein 13

958 amino acids

Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, atg13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

102.909 kDa

MHQHPRSPAPAAPPSASRPGANRSDDRPNSPAFDPRVQLTRGLGIETEARSSGQTSSSRPAKEAISKLNQLVTNYHTKAALVILASRIDLTRSDDTPKINPKVNRWFAIDLEDIDALREQLRFWRINDVSEQPPPPLIIETYLDTKDLTNNQSLVALDEQGKRFDVLESLSRSSEAHAKGPVSSRSEDVILERWRVELGNTPNKALPADLGSILPKIYKQSIVTFRTLFTYSKLLPAWKLAKRNGRLHAHPALQIRYRILAGKPNPDDSRPDRLTTPLFDSSNKVVETYTFGTTESPVGYLSIQVTYRTSCEFRVDDSEALLSSRFMGADDEVFRPSLPSRESNLKAANSGVGSAPVEKRTVEDPDPSRAYGSLSTFHHVGPTTSASPISALRAARESGAASPSPPSSSSRKPVEVVKASPLGRAAVLANESSPGVARRSSISFPPFKAPPLSASPSLVDPPLGMSPRSGTMTRPQFPESKNMPPPSMAASARKSLPLPGASETTATSSNSASPRPTPIARYSSAFTHRRGRPSSGNINRIDDENSSGKTSATSSNPQPGSGLLAEATGTSADSIHADDENITEFLKMLDLRKDLLRTSNSASADVTARRTTATSAALTRFQRMRDSNAQLSESMSSSMLLQRSSTSSSKQLSGVPPMVAGTSISTASSPGKPISPHTPHTPAIPSRLSSNSIVDYGNERGREQPSSVGDYTPEGPTIPHRPSVVTVNAIDIPTSPGLPFPPYRRPSSAAPPPPPVATDDDEIFPFNLRSVSLGAEERSHNSLSALQRQHDLEGAKSNTQPTRREQRPPLASEDPSRRSSSTGHGTSPHKRTSLSGPTVAPSPSNNHVYQPRFSLCRGRGLSGGPHSLSSGSSSLARGAPSDLAERDHDRDVNASGSNSGTSTVEDRRAAGRRPSSGRNIPPPSQVEEDEPLLFAMSDFGASRRSFEEGRHGNHGRRL

ATG13

Autophagy-related protein 13

929 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

100.605 kDa

MNPYQRASPRTASPASNLQTNPTRTNNPRHSADRNSYFDNPPYNDRGSEDGEDDMASRGDHMAETDQRQYQKINQVIQNFFTKSALSIVSSRVILPTSFNKNGDIRQNKWFNVILDDSDELQLRLTEWKTMDAMAGQHPPLYIEVYLDISGLGHKQSLVVHDEDGKRWDVAAALNAAQPTSRASSRPARPTQIVIERWKIYVGDIDSVHPSDLTEPLPNVYKKAVVLFRGLYANLRLLPAFKYNKSMAKQPANHTSLKLNYRILNGASERPQLDTLSLPLCPSTDPITETAHIGSTNSPIGPLCISVEYRDACEFSVEDSESLLSDQFMGLDDTYLEQKPRAAAPVPGSLPVDKLNTQETPDVGQAYGSLSTFHQVGPPTGTSPISALRAARDMPSSSPIETPPQKLPPNHRTAQGSKSSLRSNDTSSFQRRTSVSFQPFKAGSLSSSPAPGPAGPASPSSSLGRPTSAFGRNINIVPNSLNQPRNRTSLNALPQAALRAPSLPNDNAIASSASSSPKPAPITRYSSSFGHRRGKFSTGGSKTEEDALSSGKGSATSSLQRGSDTLNDGEGGSSGEMRSEDDNISDFLKLLEAKKDLKSFNRSDSSTRDATMRKTTAQLGKYQRMRDSHAQLSDSVSSSTMLHRSSSSSSRQLSSVPAMIHGTSISTASSPGKPISPHTPHTPAIPSRLSANSIIEYDQPHRSRNHRSRSRSGRTARGQGPENLEEQSEVEDDAAGIDIPLSPRPWNYQRRSSSVAQQNRNLPEDEPDMFGVRAASLPVEEGDRARDLHRITSTDLTSSGLFAQTESLASASRDNQAPDDGDSRDDLPRASSTSNTPAKRGTYSSNLRGRGGFFSQGSSTTGSTGGTSSTERQSRYNFNSRAANLDDDEPLLFQMSEIGAGGSRRSLEEARGGSSTGSARGRNSPWGGR

ATG13

Autophagy-related protein 13

927 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy (By similarity). Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure (By similarity). Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation (By similarity). Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy (By similarity). Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).

Belongs to the ATG13 family. Fungi subfamily.

99.944 kDa

MHQQPRGPARVSSPGATTQPNLPSRSNSTREAALGSRPRAGSNLVGRDVPNSPSLESPPIPAPPADSVRKLDQIIQNFYAKAAVLVLDSRIKSRPARGANGARKPNKWFQIETDEIDDFRDELKIWKNCGSLDNRPPPMVIEVYLDASRLKDSQSLVIVDENGKRWDVMEQLNSYGSSTDSSGASRRNNEVVIERWQVELKHSGMTSVDFGPILPTVYKKAIVFFRSLFITTRLLPAWKFASQGAAKNSHPALIPRCRIRLSQPDRPRYDQLRLPIDGRPDPVTEYVFGDLEVPVGRLSTLVTYRSDCNFRVDDSEALLSSRFMGVDENFFRPSLPQQHATSRAPAAEAGSLRDHRSKPNLNDIQQAYGSLSTFHGNVPIGTSPISALRSVRQPGSDTSSPPESIPAQHDVGGPSSLPVRQGTARPHLPALEGLGRRPSVSFQPFKAGSLSGSPVPRQLDAEPASPQSLTRPGIPSLRQAGNRTSLTAGMPASLRGGPPTSSGETAVAGSPRPASTSRYSSSFTHRRGRLSFGGASKAGDDEQGSSGRQSLASSVAQPGSGLLAEVAGTSSESLRDDNEQLEDFIKALDSKKTLQSFGPSKTGESATNKTVAQLSRFHMMRDSNNALTESMTSSVQMQRSSSSSSRQLTSVPGMTAPASVSASSSPGKPLSPHTPHTPAIPSRLSENSIIDYSGQGRITSRQGRTSDNTQPGTIRENTITQDGTTAIDIPLSPRLATYQRRASSVAIQNRSMADDDDTDSAFAHRSISLGADDREPPTLSILLGRQMQLEEDSTQRPSDRLEPAADTGSTETPDMLRQGLSEENPPEGLIPAATSSSPFGRRRYMGMASHKQTPPQSSRGSFNGSLNRQVRGDDDSVNEEPLVFDLSEMDPQGRRSIEEARSGASGGPNIGPDRGGYESRNASRRGW

ATG13

Autophagy-related protein 13

837 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

92.307 kDa

MVSPGQNDLSSDKSQIDPFVKKQNAKLTQVIQNFFSKSVQIVLQSRIQSESHNKEEQLKVGGDVGGHNVSSKINKWFNLHMYNDNLPKEELKLWKNINDVSQMPPMIIEVYLDLRQLTAIQTVILRDDNGNPWTVAKGGSKKHEVVLERWLIEFDANTVSGTIVDELPLIYKQAIILFRSLYGYTRLMPTFKLKKNLNKSNLNIGCKILDGKQPISSKGRIGLSKSIIPHQMLTTESHMSHKHFLPIQTTLGTLKISIAYRNHHEFSIHDNEELLSTHFVNIDDNDKDSEITPVEIEFKEELKIDRDSTTNEKVNEPEDDESHHADVESSQEHLQSEEPDESFEQDAKHISGSRKKFSISNNASMSLSPCSSGPQTVTEDSPSHNKPSANTTPIVSQRPTINPFKVGSISTSPPATTNFGGSSLERKVSITSNKSASNASLAAMLRNPRSSTSSTNTTANIPIANNNSNNQYNSTFPRSVSSSHGSNLAHDNDNLLGFSNPDNTSNTPRFSSSFGSRASRRFSNTSGRQSSLPSGNMNDTSLLATSAGSASSDAPMSGLYIDDDIGDFVRMIDSKSDLRFSGYNSNNDSKISYNQGSNSQIDALNKFQMLKNQHQQLSDSVSASLILHHNQLSGSRPSSRKSSHSIHSPPPSLPSGSYDNSHLPSINSKLRENSSTSGNDDNLARDSGTPSSRKNSFDYSTNSNTTFLKSPITNKLVSSPVTSTTPIHSCLHKTNNESGVISGLATTPSIYNDRRQIHYESVFDDDDDDYANNTADNRDQDDSLKLYLTNKLANAPKSNTNSRSLKSSTNPPNIGEDDDDDDDDLLFTMSDMNLAKH

ATG13

Autophagy-related protein 13

779 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

84.521 kDa

MASQDISYQYKSQQEHYPNEKISDSYVQKQNSKLTQVIQQCFSKAVKIIIQSRTVPPAAASPLLNPALHDDSASGNKINRWFNLHIQNSQDLPKDDLKLWKSNHLQSMPPMIIETYLDLRQLTSSQTIVLNDDNGNPWAVAKSGGKKQEVVLERWLIEFDHTDASGSIVDELPLIYKQAIILFRSIYGFARLMPAFKLKKRLLINKSSTKLNKLTIGNKILDGKQPISSKGRIGLSKTIIPRQMLTTDSHMSQKHFQPIQTSLGTLKISIAYRNHCDFCIHDNEEVLSTHFISMDSTPLTESGHGHTKANNTSMSVSPCSSGHPALREGSPTKRGTPPTAIQPFKVGSISNSPPPASHTPNSGYGGSLERRISITSNRSTSNASLFAMLRNPRSSTSSTHTTSNIPIAPSSSSNSTNATNMNNMSYPRSISSSHGSNMQHDDSMFSNPDSTTNTPRFSSSFGSRASRRYSNTSVRQSTPVAASTLTGGSPLSGLYIDDDISEFVRSIDSKADLRFSNSYTAHNSGEPKNNMGSPSGGDALNKFQMMKSHHQQLGDSVNASLILQHNNAVSGSGSGFGVSNSRHSSTSRKSSHSIRSPSPSMSGLYDVVPGSYGRSERRSSSGAGVPGQLSLPSGGGLAAHSPSATEPTSAATITPRETNFNFSNASFLRSASKLSATPVTSTTTAHATIHSVTGMATSPSLYQRTKVGSSIHYENVFEDDDDDEMVMKKPVVTSSGRDEEQLQHKQMKVVSIEKDAGANNFDDDDLLFTMSDMNLTKSS

ATG13

Autophagy-related protein 13

761 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

84.411 kDa

MLSDFKQQQQQKHHSHNPPNSHDDTQTKLQVAKLTQVIQKFFTKAAQIILESRAYPETSTPSLYPTKEESSKINKWFNLYMTNIPDSCKDDLKLWKGVDLTTIPPMIIETYIDLRSLPADQTLVLMDDEKHPWTVAKSRGKKQEVVLERWLIEFEPNTTDATVMVEELPLSYKQAIVLFRSIYGFTRLMPAFKVKKNLQNKLPLGNKILDGNQPISSKGRIGLSKPIINTRTNESHMTQKYFQPVHTSLGTLKISVAYRMDSEFCLHENEELLSSHFHKRDEEETKKKVSSSVSPLSSGTSLKETSTSPRKSQPPIRIQPFKVGSMSTSPPVQSPSISQPGTAPIQNQPSVPSSSLERRVSITSNKSTSNASLAAFLRNARSSTPSANNIPIINANPISGTSVPRSFSSSTGHEDSIFVNPDSASNTPRFASSFGSRASRRYSSTSIRQQTPQSDLMGQTNSVDAALSGIDADDDISDFVRMIDSKSDLRLGGGGGGGNSSVHNMSINESSYHGDALNKFQSLRSQYQQLSDSVSASLILQSRHSSRKSSLNSPAGSFDSHHHQHQQQQQQQQNQQQSQSPHTNTTSSIHSHAHSYSHSRMKDARPRSEDHQQTKFSAARRSSNISPTTAVPSSIGTPSSISSRIPHVTTIISSSDVSSTGGNRTKSAATTAIVSGMATSPSIYDYRSPRYQNVFDDDDEDDNDEEEGDREGNQLHEGRNSTESSQNQSKRIMKHIKKDEEDSEDDEDLLFTMSDMNSRNF

ATG13

Autophagy-related protein 13

712 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy (PubMed:26442587, PubMed:24793651). Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure (By similarity). Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation (PubMed:24793651). Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy (By similarity). Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

78.683 kDa

MSDSDREIIGLINNFFLKAALLLEQCKVVARGGGFDGEEPLRDGNHLFNIETRGDPTLEAQIQPWTTFDGEKSMPPLVLETFLDLRGLHSNQTVYLHDSDGNPWMVCKGGKKSEIVLERWLIELDRQFSSTTGSTDAAEDDEYNEFNDPENLHKQLVLLFRYLYTLTQLLPANDIITKLQASQQGTAQATTTTGTLKPLHIHTRLLDGSKPILSKGRVGLSKPIIASYSNTMNETNIASHLEQRKITPIKTKFGSLRITVSYRKDVDFYVIDQEDPYKRTTNVSALQDTVTATDRRISSNSNISISVSPKTTNMLNANHIPVDSSGGGFARRQSISSKLQPFKVGSVGSGSFVQSGSLQSVTNPNPSLSRNVSSSSVAAALKVQRGSAGSTVLNSDLPPELSSVGSGSKYSSSFGRIRRHSSVRRSESIDRTAKPRKSNETPPEDLLEFVKLLEDKKELNMKPSTILPQQDISSSLIKFQSMKPNNDTLSDNLSMSMSIDQPNMRMGSNSHSPIPSFSPNYGSIPSRLSQGSRNNSNVELITSRKSSLDRHRLSLLNRTGSNVDIRRGSVGTMETTNEDSKEDEDSHVHGLRFNSGTVNDKTEDNNEDDDEEEILIKRSSNAVASSTEHFSVSPRSARSISVSSYTRSQLPLKHPNFSYPTTSATTAHAKFHKSEVIPDQLHREGSHHHNSSHKNDEDDDLLFVMSDMNLTN

ATG13

Autophagy-related protein 13

701 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

77.933 kDa

MSSARRPSKLLSEKQSDKLAQIIQNFFLKAAHVIFHFRVAFPSVVLQPDDSYGAMGDTFSQSKYNNRWFNLDLGNYEIPRTELSLWRNKDILSLPPLVLETFLDLRGLSSNQTLMLDDVIVKTSKKSEIVLERWLIEFDLSTFDNEVMEFPSIYKKIIILFRSLYLLAGLLPSYRLRDKLVKSKSKNSAIHVSCRILDGSKPITSKGRIGLSKKLLSEEEHTSSKKLQPVLTPIGALRVSVSYRTNCNFQVSDTEEALSSQFMLDHLPSVRTNYDSDGNSLTSPMDYLQNRVSSASIHWSDQSPRRRSSTRSVQLFKVGSINSSSSPPPGATQSNQSVSSFSTSKPIPVTLNKTNSSASLVPILRQNKDSLPKSIGSMVQNQMQETGHQVSSNSRRFSSSFGSRFRTVSSRNNSLDGQLVVANQPFSTPSNNPILHNFRSRNKSPSVSSTELGPSSSIYMDDDLDSFMKMLDSKPDLRFPSNSPSVYEDPLANFKTFQKSNDFLALEQQQHGSPTSNQIMIHSQSQTSQSQVFKRTVFSDRSRRGSVSSNYSPSSQALRPGASAPMVTPSVTYGKFHASSGSPSNSSLAQYLRHNSSPPASATAVATVHNSLRRLTSSSQRTNTNSTNSSTRPVNPELLKLKSFNEDVFESDDDEHDEHSPRSTDTKSRNTGPSSGHAEDDEDDLLFAMSDMTLAKNNQEF

ATG13

Autophagy-related protein 13

700 amino acids

Acts as a negative regulator of xylose alcoholic fermentation, a role that is not related to autophagy (PubMed:29438555).

Belongs to the ATG13 family. Fungi subfamily.

77.768 kDa

MSSVRRPSKLLSEKQSDKLAQIIQNFFLKAAHVIFHFRVAFPSVVLQPDDSYGAMGDSFAQSKYNNRWFNLDLGNYEIPRTELSLWRNKDILSLPPLVLETFLDLRGLSSNQTLMLDDVIVKTSKKSEIVLERWLIEFDLSTFDNEVMEFPSIYKKIIILFRSLYLLAGLLPSYKLRDKLVKSKSKNSAIHVSCRILDGSKPITSKGRIGLSKKLLSEDEHTSSKKLQPILTPIGALRVSVSYRTNCNFQVSDNEEALSSQFMLDHLPSVRTNYDSDGNSLTSPMDYLQNRVSSASIHLSDQSPRRRSSTRSVQLFKVGSINSSSSPPPGATQSNQSVSSFSTSKPIPVTLNKTNSSASLVPILRQNRDSLPKSIGSMVQNQMQETGHQVSSNSRRFSSSFGSRFRTVSSRNNSLDGQLVVANQPFSTPNNPILHNFRSRNKSPSVSSTELGPSSSIYMDDDLDSFMKMLDSKPDLRFPSNSPSVYEDPLANFKTFQKSNDFLTLEQQQHGSPSSNQIMIHSQSQTSQSQVFKRTVSSDRSRRGSVSSNYSPSSQALRPGVSAPMVTPSVTYGKFHASSGSPSNSSLAQYLRHNSSPPASATAVATVHNSLRRLTSSSQRTNTNSTNSSTRPVNPELLKLKSFNEDVFESDDDEHDEHSPRSTDTKSRNTGPSSGHAEDDEDDLLFAMSDMTLAKNNQEF

ATG13

Autophagy-related protein 13

684 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

76.008 kDa

MSEGEVQVIELINNFFLKSALLLEQSKVAHNFDTEEALRDGNHLFNIETRGDPLLEAQIQPWITFDGVKTMPPLVIETYLDLRALQPNHMVYLHDADGNPWMVCKGGKKTEIVLERWLVELDKQTIDDSIDSNDPENLHKQLVLLFRYLYTLTQLLPANDIITKPHNSQQPALINVQTRLLDGSKPILSKGRVGLSKPIIASYSNTMNETNIASHLEQRKITPIKTTFGSLRITVSYRKDVDFYVIDSDDLQKRYMTPSLSNETTTVPDRRASSNCSRSMSVSPKTNTINATLFPLEGSSARRQSISSKLQPFKVGSVGSGSFVQSGSAQSTTSLVPSLSRNVSSSSVVAALKVQRGSAGSTIVNGDVPPELSSVGSGSKYSSSFGRIRRHSSIRRSESFDRTAKPRKSTENPPEDLLEFVKLLEDKKELNMKPNTILPQQDISNSLMRFQSMKSNNDALSDNLSMSMSIDQPNVRFGSNSHSPIPSFSPNYGSIPSRLSQGSRNNSNAELITSRKSSLDRHKHNLLSRTGSNVDINRRGSVGTMETTNEDSKEDEQSHMKGMHFSNEATINKDDDEDEMLMKRSFNAGTSTTEQVMGSPRSIRSISVSSYPRNQLPLKHLNLSHPTTSATTTHAKFHKSEMSPDPLHTEGAQPHTSSQHHNSSQKNDEDDDLLFVMSDMNLTN

ATG13

Autophagy-related protein 13

669 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

74.106 kDa

MEKPKQKLTQVTVNFFLKTSQMILQARSLDEHGKGKLNKWFNLHTFNSDDLRSELRLWRSTIDLTAVPPMIVETYLDLGNLPQGHTLALKDEHGNLWPVTKGGSKKTEVVLERWLVEFDPNEFGTIEELPYIYKQAIILCRSIYTIIRIMPAASLRNQSPHYVLANKIVDGSKPISSKGRIGLSKTIIPHQMLTDTHVRHRTFSPIETSLGTLKVSVAYRSHCEFTELAEWDHRELGREKEPREDLRQVESKGEEDHSIESIPYEEKAYKTDEEKSDKTPEHVQYKPFKPEFKQLEAVKLEGSDFKSELHEGTSPLSLSGSPSSPPRDDKKRPSIQPFRVGSIGNSPPPASSSLERRISITSNKSTSNASLAAVLRNPRSSFSIPIAGSIGTGAPVTGGFPRSVSSSHGYGYEDSDSAANTPRFSSSFGSRASRRFSNTSVRHGSLHDTTSPLGTSAGSATSIPLSGLYIDDDISDFVRMIDSKQDLRFGHDSGGSGSQSGSQYEVLNRFHQLKSQHQQLGDSVNASVMMHRKSSSPPGSYESHVPSIHSRLRESSEPHPAPATAPAPGPLIKPASKMMSSPVISTTSAHAMSQTASATTRDEIVGLATTPSTYRKHLHYENVFDDDDEDEDHHGYFKAKARSKSLSRSHFDDDDDLLFTMSDTNLAKH

ATG13

Autophagy-related protein 13

660 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

74.347 kDa

MSNGNDNQVIELIQNFFLKSAGLVTTVESNRYSLDDTSIEFDDEWFDMNIDVLHDLPPIIDKWTNFDGTQELPPLVIETFLDLHLLPSSYTVRLRDDESHLWAVSKGNKKSEIVLERWLIELDKESTSFKNHVQSGSGVSPEKLDQQLRLLFRYLFTLLQLLPSNDLMMALNNQSESHNTPIPVDIKTRILDGSQPILSKGRIGLSRPIISSYSNIINNSNIPAHLEQKKITPVWTKYGLLRISVSYRRDCQFIFQDLNEDNSPNTQITNQPAKTNEISISLSPRSKNDLNQISHPSWQKKFISSSKQFQPFIVGSVGSANTPNQNSSRNPSNSSVVGPHYHPQHRLSIGSSTSVSTQPNYEGTSVGSTSKFASSFNNLRRHSSVRYHESTEKLAKTDKNNYEDTDDLMEFVRLIEAKPELQPKKGLSGLQDKNLSGSILRYQKLRPSNDMLSEDLALSVSIDPIHGSQRRNSNSHSHSPVASFSPSGHFSSINSKLSQPHLAVRGSSSTVNSRRNSVDKVLASALSPIYGGDIPEYHTKSHNPVFNEVDDEEEGNDDLLVNKIPININKHKMSTSPRSIDSISNSLTRNRTPFRQPYQYSQPTTIATQAYAKMHRPTVRSSDAISEINSRKGDNFHQLINDNDEDDLVFFMSDMNLPRE

ATG13

Autophagy-related protein 13

659 amino acids

Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).

Belongs to the ATG13 family. Fungi subfamily.

71.59 kDa

MAMESECNVVELIGGFFLKATLLVCQPRTGAIEGDGEEDRTFNISSAADAGVAEAVRAWTAYDGAQELPPLVIEMFLDLRRLGPQHTVVLKDQDGNPWNVCKGGKKSEIMLERWLVELDVGNEEARPEEPPNAAEIYKQLVLLFRYLYTLTQLLPANELYARLHGPSNQGEAAMPLINIGTRILDGSKPILSKGRVGLSRSIIATYTNVINETNVASHLEQKKITPISTGYGSLRITVSYRRDCNFDVNEVLDYEGNNCSSSSVVDTHTKPGVGPLSSLRRVSIHSNRSMSISPQTVYSGTVIPDPSPQRKSSSSRIQPFKAGSVGSGSLAIARNPSGSSAVATLRAQRSGSASISTHVADQAVGEPSSVGSGGSKYSSSFGKIRRQSSMRRSGSLELPAAKQAKPGERGSDELLDFVKMLEEKQELNVKKLYGTTTDISSSLVRFQSMKSNNDTLSEDLSMSYSLEPTHAPQVRYRSNSHSPIPSISPSVQYTSIPMRLSQSRNVSQTELASRKNSAERLKTLISSRTGSFSESRRQSNAGQEDILEDEDDEAEEILLSKSHLSNPTGTRLQSMSPQSLKSISSYNRAAVPFKPVSNFSCPTTMATPAHAKLHKASISSSPDNQSGLVKKDHEHSTMTGGDDDDDLLFFMSDMNLSSQ

Atg13

Autophagy-related protein 13 homolog

523 amino acids

Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of Atg13 and Atg1. The Atg1-Atg13 complex functions at multiple levels to mediate and adjust nutrient-dependent autophagic signaling. Involved in the autophagic degradation of dBruce which controls DNA fragmentation in nurse cells.

Belongs to the ATG13 family. Metazoan subfamily.

56.927 kDa

MSAQRLNAAERDLEKFIKFLVLKSTQVVVQSRLGEKMQTQCNPLAGSDWFNIAVQDHPEVLDETKRALNLKTGESILQRLPLCVEISLKTTEGDQMVLEVWSLDLLQPQNGASPATNDLNPEGQTLKAAHAIYNRMGIMLKSLISLTRTTPAYKLSRRQCPDSYGIFYRIYVDRPQVHTLGEGHKHVKIGQLSTIVGSLVMSVAYRTKLTISPTAAQSESNTIMLKSDHFRPATDANTPGNQQQTQNGTVVAKKLGLGALNPAQGTADRRFIDIEKPLRPGAFTDMGKLKQYTEDDFVLPETPPFEWLLRGRGSVESLNRLDNNSVASVNISNNNNSTQDSKFNQISNLNNNSAGFKSFEKNSENSVSPIKSLLIPASATATYRHHSEPSLQPPPDDDNLLKELHFPFASPTSHVNDLAKFYRECYHAPPLKGLNELQAEISSISSTPPASSGSGGVAACGPTAAATAIATSSADASAMDDLSRQLEQFETSLEDYDKLVSQFGLTGSSSTGSRSSGGLQMSN

ATG13

Autophagy-related protein 13

517 amino acids

Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Belongs to the ATG13 family. Metazoan subfamily.

56.572 kDa

METDLNSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKKALAGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCDKEIKVSYTVYNRLSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGEVQLSGLGEGFQTVRVGTVGTPVGTITLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAGEDTGVIYPSVEDSQEVCTTSFSTSPPSQLSSSRLSYQPAALGVGSADLAYPVVFAAGLNATHPHQLMVPGKEGGVPLAPNQPVHGTQADQERLATCTPSDRTHCAATPSSSEDTETVSNSSEGRASPHDVLETIFVRKVGAFVNKPINQVTLTSLDIPFAMFAPKNLELEDTDPMVNPPDSPETESPLQGSLHSDGSSGGSSGNTHDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLSIDIGAQSMAEDLDSLPEKLAVHEKNVREFDAFVETLQ

Atg13

Autophagy-related protein 13

516 amino acids

Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Belongs to the ATG13 family. Metazoan subfamily.

56.441 kDa

METELSSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKKALSGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCDKEIKVSYTVYNRLSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGEVQLNGLGEGFQTVRVGTVGTPVGTLTLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAEDAGVAYPSVEDSQEVCTTSFSTSPPSQLSSSRLSYQPAVLGLGSADLAYPVVFTAGLNTTHAHQLMVPGKEGGVTLAPSHPTHGAQADPERLVMHMPSDGTHCAATPSSSEDTETVSNSSEGRASPHDILETIFVRKVGAFVNKPINQVTVTSLDIPFAMFAPKNLELEDADPMVNPPESPETTSPLHGSLHSDGSSGGSGGSTHDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLSIDFGAQSMAEDLDSLPEKLAVHEKNVREFDAFVETLQ

atg13

Autophagy-related protein 13

503 amino acids

Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.

Belongs to the ATG13 family. Metazoan subfamily.

54.737 kDa

MDSDLSPQDKKDLDKFIKFFALKTVQVIVQARLGEKISTCSSSSPTGSDWFNLAIKDIPEVTHEAKKALAGQLPGIGRSMCVEISLKTSEGDSMELETWCLEMNEKCDKDIKVSYTVYNRLSLLLKSLLAITRVTPAYKLSRQQGHDYVILYRIYFGDVQLTGLGEGFQTVRVGIVGTPIGTITLSCAYRTNLALVSSRQFERTGPIMGIIIDHFVERPFTNMAHTHPCSYRAPGEDDGGTYAGIEDSQEVCTTSFSTSPPSQLYSSRLSYQTPPLGTVDLCHPTACTGAAHPHQMVVPGKDGGIPQVPAQPNHGTGAEQGRIPSCPTGQPPQLPPPTSCSSEVKTVSPSDVLETTFTRKVGAFVNKATTQVTTTGLDLPFAAFAPRSYDMEENDPMVHPPPSPIPSSPLQGSLHSNNSSHSGGQPNDDFVMVDFKPAFSKDDLLPMDLGTFYREFQNPPQLASLSIDVSAQSMAEDLDSLPEKLAVYEKNIDEFDAFVDTLQ

ATG13

Autophagy-related protein 13

480 amino acids

Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Belongs to the ATG13 family. Metazoan subfamily.

52.426 kDa

METDLNSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKKALAGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCDKEIKVSYAVYNRLSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGDVQLNGLGEGFQTVRVGTVGTPVGTITLSCAYRINLAFMSTRHFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAGEDTGVACPSVEDSQEVCATSFSTSPPSQLMVPGKEGGVPLGPSQPAHAAQADQERLATYTPSDGAHCAATPSSSEDAETVSNSSEGRASPHDVLETIFVRKVGAFVNKPINQVTLTSLDIPFAMFAPKNLELEDADPMVNPPDSPETTSPLQGSLHSDGSSGGSSGHTQDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLSLDIGAQSMAEDLDSLPEKLAAHEKNVREFDAFVETLQ

ATG13

Autophagy-related protein 13

474 amino acids

Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.

Belongs to the ATG13 family. Metazoan subfamily.

52.069 kDa

METDLNSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEITHEAKKALAGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCDKEIKVSYTVYNRLSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGEVQLSGLGEGFQTVRVGTVGTPVGTITLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAGEDTGVIYPSVEDSQEVCTTSFSTSPPSQLMVPGKEGGVPLAPNQPVHGTHADQERLATCTPSDGTHCAATPSSSEDTETVSNSSEGRASPHDVLETIFVRKVGAFVNKPINQVTLTSLDIPFAMFAPKNLELEDTDPMVNPPDSPETESPLQGSLHSDGSSGGSSGNTHDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLSIDIGAQSMAEDLDSLPEKNVREFDAFVETLQ