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ATAD5

Gene
ATAD5
Protein
ATPase family AAA domain-containing protein 5
Organism
Homo sapiens
Length
1844 amino acids
Function
Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.
Similarity
Belongs to the AAA ATPase family.
Mass
207.57 kDa
Sequence
MVGVLAMAAAAAPPPVKDCEIEPCKKRKKDDDTSTCKTITKYLSPLGKTRDRVFAPPKPSNILDYFRKTSPTNEKTQLGKECKIKSPESVPVDSNKDCTTPLEMFSNVEFKKKRKRVNLSHQLNNIKTENEAPIEISSDDSKEDYSLNNDFVESSTSVLRYKKQVEVLAENIQDTKSQPNTMTSLQNSKKVNPKQGTTKNDFKKLRKRKCRDVVDLSESLPLAEELNLLKKDGKDTKQMENTTSHANSRDNVTEAAQLNDSIITVSYEEFLKSHKENKVEEIPDSTMSICVPSETVDEIVKSGYISESENSEISQQVRFKTVTVLAQVHPIPPKKTGKIPRIFLKQKQFEMENSLSDPENEQTVQKRKSNVVIQEEELELAVLEAGSSEAVKPKCTLEERQQFMKAFRQPASDALKNGVKKSSDKQKDLNEKCLYEVGRDDNSKKIMENSGIQMVSKNGNLQLHTDKGSFLKEKNKKLKKKNKKTLDTGAIPGKNREGNTQKKETTFFLKEKQYQNRMSLRQRKTEFFKSSTLFNNESLVYEDIANDDLLKVSSLCNNNKLSRKTSIPVKDIKLTQSKAESEASLLNVSTPKSTRRSGRISSTPTTETIRGIDSDDVQDNSQLKASTQKAANLSEKHSLYTAELITVPFDSESPIRMKFTRISTPKKSKKKSNKRSEKSEATDGGFTSQIRKASNTSKNISKAKQLIEKAKALHISRSKVTEEIAIPLRRSSRHQTLPERKKLSETEDSVIIIDSSPTALKHPEKNQKKLQCLNDVLGKKLNTSTKNVPGKMKVAPLFLVRKAQKAADPVPSFDESSQDTSEKSQDCDVQCKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDGCCLWHLKPPSCPLLTKFKELNTKVIDLSKCGIALGEFSTLNSKLKSGNSAAVFMRTRKEFTEEVRNLLLEEIRWSNPEFSLKKYFPLLLKKQIEHQVLSSECHSKQELEADVSHKETKRKLVEAENSKSKRKKPNEYSKNLEKTNRKSEELSKRNNSSGIKLDSSKDSGTEDMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRRAELEERQNLKGKRDEKHEDFSGGIDFKGSSDDEEESRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNSYYIGKSPKKISSPKKVVTSPRKVPPPSPKSSGPKRALPPKTLANYFKVSPKPKNNEEIGMLLENNKGIKNSFEQKQITQTKSTNATNSNVKDVGAEEPSRKNATSLILFEEVDVIFDEDAGFLNAIKTFMATTKRPVILTTSDPTFSLMFDGCFEEIKFSTPSLLNVASYLQMICLTENFRTDVKDFVTLLTANTCDIRKSILYLQFWIRSGGGVLEERPLTLYRGNSRNVQLVCSEHGLDNKIYPKNTKKKRVDLPKCDSGCAETLFGLKNIFSPSEDLFSFLKHKITMKEEWHKFIQLLTEFQMRNVDFLYSNLEFILPLPVDTIPETKNFCGPSVTVDASAATKSMNCLARKHSEREQPLKKSQKKKQKKTLVILDDSDLFDTDLDFPDQSISLSSVSSSSNAEESKTGDEESKARDKGNNPETKKSIPCPPKTTAGKKCSALVSHCLNSLSEFMDNMSFLDALLTDVREQNKYGRNDFSWTNGKVTSGLCDEFSLESNDGWTSQSSGELKAAAEALSFTKCSSAISKALETLNSCKKLGRDPTNDLTFYVSQKRNNVYFSQSAANLDNAWKRISVIKSVFSSRSLLYVGNRQASIIEYLPTLRNICKTEKLKEQGKSKRRFLHYFEGIHLDIPKETVNTLAADFP

Gene
Atad5
Protein
ATPase family AAA domain-containing protein 5
Organism
Mus musculus
Length
1826 amino acids
Function
Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis.
Similarity
Belongs to the AAA ATPase family.
Mass
203.909 kDa
Sequence
MVGVLSMAAAAAPLPVKDYEIEPCKKRRKDDDNSSCETITKYLSPIGKTGDKVFSPPKPSNILHYFRKTSLTTEKPQSTKAYKIKPSPPLLVGNSKDCKTPLEVFSNREFKRKRKRVSLSSQLNDIKIQDECPVEISNNDSKEDGGLSDCVESSASVSLYKEHVEVLAESIEDSRNQPNTKSSKKKVNPKQCTTKSDDRILRKRKRSKVTGQSESVPLADELSLPEDGGKDSKLTKPSLAEENDSRTHATKRADLKESTITVSYEEFVKSHKAAKVEEIPDPAVPACVPSGPGEAVKSGSEGELSGSCEPSPQLHLKTVTVLAQVHPTPPKKKGKIPPIFLKQKQPELENSLSDPENEQPVQKRKSNVVIQEGQLELAVLEAWNSEASVPKCSMEERQQFMRAFRQPPPDTLKNGFKKPLEKQKDPSEKSVHEGDSSSEKIIENPNIQRVSSQGCLQSHADRGSFPKEKSKKPNKKGKKTRTTAGGNREENIQKEKTAFSLKDEQDQNSLRRSVRQKSEVLKSNALLNSENLVCEDTAHDSVQMSLCNRNKSRSSSTPTRDMVTHHRAEPGSSLEYVSTRQPIRRSLRSCSTPATNALGGTESEDAQDTIPVKASTPKSARTSEKHNLYTAELIIVSSDSESPIRMKFTRISTPKKSKKSSKKSETTEEELTSQKKKANSTSKNISKAKELIEEAKAFQIGGSKTEETVVPLRRSSRHQARSAKEKSPEIDDSVIVIDSSPTSIREPEKSQKKLQNLNDVLGKKLNKSSKNVPGKMKIAPLFLAKRTKRAAIPVFDLDESSQDSSEQTQDCDVQFKAKRDFLMSGLPDLLKRQIAKKAAALDVYNAVSTSFQRVVHVQQKDDEYWLWHLKPPSCPLLTEFKELNTKVTDLSEYVVAFGEFSTLNPNPRSNPAAVMMRTRKDFTKEVRNLLLEEIKCSNPEFSLEKYFPLLLKKRIEHQVLCEGHGKQASPQLQPDVSQKETKRKQVATGNQKSKRKRQNEYSVSPEEMKGRSKDLDERISSSCTNLDPSRDSGTEDMLWTEKYQPQNSNELIGNELAVKKLHSWLKDWKRRAELEERHNLKGKRDEKEEGILDLSDSTDFKGSSDDEENRLCNTVLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQILSQLKEATQSHQVDKQGVNSQKPCFFNNYNIGKSPKKLNSPGKVVTSPRKLPPSSPKTSGQKRALLPKTLANYFKVSSKSKSNDDVGALMGDDKGVKNSSLEQRQLIQTKSTNANNSHIKDVGAEESNRKKATSLILFEEVDVIFDEDAGFLNAVKTFMATTKRPVILTTSDPTFSLVFDGCFEEINFSIPSLLNVASYLQVICLVENFRTDFKDFVTLLTANACDIRKSILYLQFWIRSGGGILEERPLSHCRENSRNTLVCSEDGSDANINSKKPKRNRVALPRCDTGCAEALFGLKNIASPSQDLLSLLKHKITTKEEWQKLIQVLTEFHVQNIDLLHSNLEVILPLPVHVVPDVRGAYGFPVTTQASAPASMGHLTRKQSKDQPLRKSQKRKQKKMVILDDSDLFDTGLDFSGELPSLSPAPSLSVEDNIRRDSNPEIKTQNSGFKPHSVPQPPKTLAEKKCCMLVSHCLNSLSEFMENMSFIDALLTDPGEQNELGRSAFHWTNGRVKSGLCDEFSLENRDRWAPQSAGELKATAEALSFTECSSTISKALESLNSCKQLERDPTNELTVCVSQRRHDACFRQSAANLDNADKRMAVIKSVFSSRSFLTLGNKQASIIDYLPTLRNICRTEKLKEQEKNKRRFLHYFEGIHLEIPEETITTLAADFP