ASPM

Abnormal spindle-like microcephaly-associated protein homolog

3479 amino acids

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).

410.106 kDa

MANRRVGRGCWEVSPTERRPPAALRGPATEEEASSPPVLFLSHFCRSPFLCFGDVLLGDSRTLPLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQPKEKIVISVNWTPFKEGRVREIMTFLVNDVLKHQAILLGNAEKQKKKKRSLWDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENNSLTLEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSLHASENRELLNVDSANVSKVSFNEKAVTETSFNSINVNDQSGENSKLILTPNYSSTLNITQSQINFLSPDSFVNNSHGANNELELVTCLSSDMFMTDNSKPVHLQSTTAHEIYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQTYKVPLSNENSQVPQSPQDWSKSEVSPCIPEYQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSAVQDISSHSHDKQPKRRPILSATVTKRKPTCTRENQTEINKPKAKRCLNSAVGEHEKVIHNQKEKEDFHSYLPVIDPVLSKSKSYKNQIMPSLTTASVARKRKSDGSMEDANVRVAVTEHTEEREIKRIHFSPSEPKTSAVKKTKNVITPISKCISNREKLNLKKKTDLLIFKTPISKTSKRTKPIIAVAQSNLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLGVENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETIYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYRDGHEGALSKFTLKKLLLLICFLDYAKISKLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDEFDFAITNLAVDLQCGVRLVRTMELLTQNWNLSKKLRIPAISRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDALINKKKGKRDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHENTSELYKELLENEKKNFQLIRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQERDKAARIIQSAVINFLAKQRLRKRVNAALIIQKYWRRVLAQRKLLILKKEKLEKVQNKAASLIQGYWRRYSTRKRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSSLIIQSMFRKWKRRKMQSQVKATVILQRAFREWHLRKRAKEENSAIVIQSWYRMHKELRKYIYIRSCVIVIQKRFRCFQAQKLYKRKKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLCRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKLQAHIRKHQQLQKYKKMKKAAVIIQTHFRAYIFTRKVLASYQKTRSAVIVLQSAYRGMQARKVYIHILTSVIKIQSYYRAYVSKKEFLSLKNTTIKLQSIVKMKQTRKQYLHLRAAALFIQQCYRSKKITTQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRKAVISLQSYFRMRKARQYYLKMCKAIMVIQNYYHAYKAQVNQRKNFLRVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQSIIKIQRWYRAYKTLHDTRTHFLKTKAAVVSLQSAYRGWKVRKQIRREHQAALKIQSAFRMAKAQKQFRLFKTAALVIQQNFRAWTAGRKQRMEYIELRHAVLILQSMWKGKTLRRQLQRQHKCAIIIQSYYRMHVQQKKWKIMKKAALLIQKYYKAYSIGREQHHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITHRQHQEYLNLKKTAIKIQSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRFRAYYQGKMHREKYLTILKAVKILQASFRGVRVRWTLRKMQIAATLIQSNYRRYKQQTYFNKLKKITKTIQQRYRAVKERNIQFKRYNKLRHSVIYIQAIFRGKKARRHLKMMHVAATLIQRRFRTLMMRRRFLSLKKTAVWIQRKYRAHLCTKHHLQFLQVQNAVIKIQSSYRRWMIRKKMREMHRAATFIQATFRMHRVHMRYQALKQASVVIQQQYRANRAAKLQRQHYLRQRRSAVILQAAFRGVKTRRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHKLHQFLQLRKAAITIQSSYCTIRRLMVKKKLQEMQRAAVLIQATFRMHRTCVTFQTWKQASILIQQHYRTYRAAKLQKENYIRQWHSAVVIQTAYKGMKARQHLREKHKAAIIIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKKQKALQHNELKKETCVQASFQDMNIQKQIQEQHQAAIIIQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRRDIQNMHRAATLIQSFYRMHRAKVDYQTKKTAIVVIQNYYRLYVRVKTERKSFLPVQKSVRTIQAAFRGMKVRQKLKIVSEEKMAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKASDLACSQEAECHSQSRAAVTIQNAFRRMVTRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQAMWRRYRAKKYLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTWFLNVRASAIIIQRKWRAILSAKIAHEHFLMIKRHRAACLIQAHYRGYKERQVFLRQKSAALIIQKYIRAREAGKRERIKYIEFKKSTVILQALVRGWLVRKRILEQKTKIRLLHFTAAAYYHLNALRIQRAYKLYLAVKNANKQVNSVICIQRWFRARLQQKKFIQKYSIKKIEHEGQECLSQQNRAASVIQKAVRHFVLRKKQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLYKRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIFVLIRSCNRSVPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDTLLELLQIYREKPGNKVADKGGSIFTKTCCLLAVLLKTTNRASDVRSRSKVVDRIYSLYKLTAHKHKMNTERILHKQKKNSSISIPFIPETPVRTRIVSRLKPDWVLRRDNMEEITNPLQAIQMVMDTLGIPY

ASPM

Abnormal spindle-like microcephaly-associated protein

3477 amino acids

Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.

409.8 kDa

MANRRVGRGCWEVSPTERRPPAGLRGPAAEEEASSPPVLSLSHFCRSPFLCFGDVLLGASRTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQPKEKIVISVNWTPLKEGRVREIMTFLVNDVLKHQAILLGNAEEQKKKKRSLWDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENNSLILEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSLHASENRELLNVHSANVSKVSFNEKAVTETSFNSVNVNGQRGENSKLSLTPNCSSTLNITQSQIHFLSPDSFVNNSHGANNELELVTCLSSDMFMKDNSQPVHLESTIAHEIYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQTCKVPLSNENSQVPQSPEDWRKSEVSPRIPECQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSAVQDISSHSHNKQPKRRPILSATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKEDFHSYLPIIDPILSKSKSYKNEVTPSSTTASVARKRKSDGSMEDANVRVAITEHTEVREIKRIHFSPSEPKTSAVKKTKNVTTPISKRISNREKLNLKKKTDLSIFRTPISKTNKRTKPIIAVAQSSLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLGIENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYRDGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDDLINKKKGKRDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHENTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQLAVINFLAKQRLRKRVNAALVIQKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRQRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATVILQRAFREWHLRKQAKEENSAIIIQSWYRMHKELRKYIYIRSCVVIIQKRFRCFQAQKLYKRRKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLCRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKFQAHVRKHQQRQKYKKMKKAAVIIQTHFRAYIFAMKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSTVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRKAVISLQSYFRMRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQSIIKIQRWYRAYKTLHDTRTHFLKTKAAVISLQSAYRGWKVRKQIRREHQAALKIQSAFRMAKAQKQFRLFKTAALVIQQNFRAWTAGRKQCMEYIELRHAVLVLQSMWKGKTLRRQLQRQHKCAIIIQSYYRMHVQQKKWKIMKKAALLIQKYYRAYSIGREQNHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITNHQHKEYLNLKKTAIKIQSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRCRAYYQGKMQREKYLTILKAVKVLQASFRGVRVRRTLRKMQTAATLIQSNYRRYRQQTYFNKLKKITKTVQQRYWAMKERNIQFQRYNKLRHSVIYIQAIFRGKKARRHLKMMHIAATLIQRRFRTLMMRRRFLSLKKTAILIQRKYRAHLCTKHHLQFLQVQNAVIKIQSSYRRWMIRKRMREMHRAATFIQSTFRMHRLHMRYQALKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKTRRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHKLYQFLHLRKAAITIQSSYRRLMVKKKLQEMQRAAVLIQATFRMYRTYITFQTWKHASILIQQHYRTYRAAKLQRENYIRQWHSAVVIQAAYKGMKARQLLREKHKASIVIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKKQKVFQHNELKKETCVQAGFQDMNIKKQIQEQHQAAIIIQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKDIQNMHRAATLIQSFYRMHRAKVDYETKKTAIVVIQNYYRLYVRVKTERKNFLAVQKSVRTIQAAFRGMKVRQKLKNVSEEKMAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKASGLACSQEAEYHSQSRAAVTIQKAFCRMVTRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQAMWRRYRAKKYLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTRFLNVRASAIIIQRKWRAILPAKIAHEHFLMIKRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQKYIRAREAGKHERIKYIEFKKSTVILQALVRGWLVRKRFLEQRAKIRLLHFTAAAYYHLNAVRIQRAYKLYLAVKNANKQVNSVICIQRWFRARLQEKRFIQKYHSIKKIEHEGQECLSQRNRAASVIQKAVRHFLLRKKQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLYKRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIFVLIRSCNRSIPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDILLELLQIYREKPGNKVADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIYSLYKLTAHKHKMNTERILYKQKKNSSISIPFIPETPVRTRIVSRLKPDWVLRRDNMEEITNPLQAIQMVMDTLGIPY

ASPM

Abnormal spindle-like microcephaly-associated protein homolog

3477 amino acids

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).

409.718 kDa

MANRRVGRGCWEVSPTERRPPAGLRGPAAEEEASSPPVLSLSHFCRSPFLCFGDVLLGASRTLSLALDNPNEEVAEVKISRFPAADLGFSVSQRCFVLQPKEKIVISVNWTPFKEGRVREIMTFLVNDVLKHQAILLGNAEEQKKKKRSLWDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENNSLTLEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSLHASENRELLNVDSANVSKVSFNEKAVTETSFNSINVNGQSGENSKLSLTPNYSSTLNITQSQIHFLSPDSFVNNSHGANNGLELVTCLSSDMFMKDNSKPVHLESTIAHEINQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQTCKVPLSNENSQVPQSPQDWRKSEVSPRIPECQGSKSPKAIFEELVEMKSNYYSFINQNNPKFSAVQDISSHSHNKQPKRRPILSATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKEDFHSYLPIIDPILSKSKSYKNKITPSSTTASVARKRKSDGSMEDANVRVAVTEHTEVREIKRIHFSPSEPKTSAVKKTKNVITPISKRISNREKLNLKKKTDLLMFKTPISKTNKRTKPIIAVAQSSLTFIKPLKTDIPRHPLPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNTSEVNAATLLLGIENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYRDGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTVELLTQNWDLSKKLRIPAISRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDIXLNLDQLKEEIAFLKHTKGIKKTISLLSCHYDDLINKKKGKRDSDSFEQYSENIKLLMDWVNAVCXFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHENTSELYKELLENEKKNFQLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQETDKAARIIQSAVINFLAKQRLRKRVNAALVIQKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRKRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATIILQRAFREWHLRKQAKEENSAIVIQSWYRMHKELRKYIYIRSCXVIIQKRFRCFQAQKLYKRKKESILTIQKYYKAYLKGKIERTNYLQKRAAAIRLQAAFRRLKAHNLCRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKLQAHVRKHQQLQKYKKMKKAAVIIQTHFRAXIFARKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSIVKMKQTRXQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRKAVISLQSYFRMRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSMLQSIIKIQRWYRAYKTLHDTRTHFLKTKAAVISLQSAYRGWKVRKQIRREHQAALTIQSAFRMAKAQXQFRLFKTAALVIQQNFRAWTAGRKQRMEYIELRHAVLMLQSMWKGKTLRRQLQRQHKCAIIIQSYYRMHVQQKKWKTMKKAALLIQKYYRAYSIGREQNHLYLKTKVAVVTLQSAYRGMKVRKRIKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITNHQHKKYLNLKKTAIKIQSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRFRAYYQGKMQREKYLTILKAVKILQASFRGVRVRWTLRKMQIAATLIQSNYRRYRQQTYFNKLKKITKTVQQRYRAMKERNIQFQRYNKLRHSVIYIQAIFRGKKARRHLKMMHIAATVIQRRFRTLMMRRRFLSLKKTAIWIQRKYRAHLCTKHHLQFLQVQNAVIKIQSSYRRWMIRKRMREMHRAATFIQATFRMHRLHMRYQALKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKTRRHLXSMHFSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHKLHQFLHLRKAAITIQSSYRRLMVKKKLQEMQRAAVLIQATFRMHRTYITFRTWKHASILIQQHYRTYRAAKLRRENYIRQWHSAVVIQAAYKGMKARQLLREKHKAAIIIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKQQKAFQHNELKKETCVQASFQDMNIKKQIXEQHQAAIIIQKHCKAFKIRKHYLHLRATVVSIQRRHRKLAAVRTQAVICIQSYYRGFKVRRDIQNMHQAATLIQSFYRMHKAKVDYQTKKTAIVVIQNYYRLYVRVKTERKSFLAVQKSVRTIQAAFRGMKVRQKLKNVSEERMAAVVNQSALCCYRSKTQYEAVQSEGVMIQEWYKASGLACSQEAEYHSQSRAAVTIQKAFCRMATRKLETQKCAALRIQFFFQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQQIKNSTIKIQAMWRRXRAKKYLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTRFLNVRASAIIIQRKWRAILSAKIAHEHFLMIKRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQKYIRAREAGKRERIKYIEFKKSTVILQALVRGWLVRKRIIEQRAKIRLLHFTAAAYYHLNALRIQRXYKLYLAVKNANKQINSVICIQRWFRARLQQKRFIQKYHSIKKIEHEGQECLSQRNRAASVIQKAVXHFLLRKKQEKFTNGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLYKRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIFVLIRSCNRSVPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDILLELLQIYREKPGNKVADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIYSLYKLTAHKHKMNTERILYKQKKNSSISIPFIPETPVRTRIVSRLKPDWVLRRDNMEEITNPLQAIQMVMDTLGIPY

ASPM

Abnormal spindle-like microcephaly-associated protein homolog

3477 amino acids

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).

409.742 kDa

MANRRVGRGCWEVSPTERRPPAGLRGPAAEEEASSPPVLSLSHFCRSPFLCFGDVLLGASRTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQPKEKIVISVNWTPLKEGRVREIMTFLVNDVLKHQAILLGNAEEQKKKKRSLWDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENNSLILEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSLHASENRELLNVHSANVSKVSFNEKAVTETSFNSVNVNGQSGENSKLSLTPNYSSTLNITQSQTHFLSPDSFVNNSHGANNELELVTCLSSDMFMKDNSKPVHLESTIAHEIYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQTCKVPLSNENSQVPQSPEDWRKSEVSPRIPECQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSAVQDISSHSHNKQPKRRPILSATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKEDFHSYLPIIDPILSKSKSYKNEVTPSSTTASVARKRKSDGSMEDGNVRVAITEHTEVREIKRIHFSPSEPKTSAVKKTKNVITPISKRISNREKLNLKKKTDLSIFRTPISKTNKRTKPIIAVAQSSLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLGIENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPSVPHLYRDGHEEVLSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDDLINKKKGKRDCGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHENTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQLAVINFLAKQRLRKRVNAALVIQKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRQRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKQRKMQSQVKATVILQRAFREWHLRKQAKEQNSAIIIQSWYRMHKELRKYIYIRSCVVIIQKRFRCFQAQKLYKRKKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLYRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKLQAHVRKHQQRQKYKKMKKAAVIIQTHFRAYIFAMKVLASYQKIRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSIVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLRRKAVISLQSYFRMRKAQQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQSIIKIQRWYRAYKTLHDTRTHFLKTKAAVISLQSAYRGWKVRKQIRREHQAALKIQSAFRMAKAQKQFRLFKTAALVIQQNFRAWTAGRKQRMEYIELRHAVLMLQSMWKGKTLRRQLQRQHKCAIIIQSYYRMHVQQKKWKIMKKAALLIQKYYRAYSIGREQNHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITNHQHKEYLNLKKTAIKIQSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRCRAYYQGKMQREKYLTILKAVKVLQASFRGVRVRRTLRKMQIAATLIQSNYRRYRQQTYFNKLKKITKTVQQRYRAMKERNIQFQRYNKLRHSVIYIQAIFRGKKARRHLKMMHIAATLIQRRFRTLMMRRRFLSLKKTAILIQRKYRAHLCTKHHLQFLQVQNAVIKIQSSYRRWMIRKRMREMHRAATFIQATFRMHRLHMRYQALKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKTRRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHKLHQFLHLRKAAITIQSSYRRLMVKKKLQEMQRAAVLIQATFRMHRTYITFQTWKHASILIQQHYRTYRAAKLRRENYIRQWHSAVVIQAAYKGMKARQLLREKHKASIIIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKKQKAFQHNELKKETCVQAGFQDMNIKKQIQEQHQAAIIIQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKDIQNMHRAATLIQSFYRMHRAKVDYETKKTAVVVIQNYYRLYVRVKTERKNFLAVQKSVRTIQAAFRGMKVRQKLKNVSEEKMAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKASGLACSQEAECHSQSRAAVTIQKAFCRMVTRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQAMWRRYRAKKYLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTRFLNVRASAIIIQRKWRAILSAKIAHEHFLMIKRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQKYIRAREAGKRERIKYIEFKKSTVILQALVRGWLVRKRILEQRAKIRLLHFTAAAYYHLNAVRIQRAYKLYLAVKNANKQVNSVICIQRWFRARLQEKRFIQKYHSIKKIEHEGQECLSQRNRAASVIQKAVRHFLLRKKQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLYKRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIFVLIRSCNRSIPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDILLELLQIYREKPGNKVADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIYSLYKLTAHKHKMNTERILYKQKKNSSISIPFIPETPVRTRIVSRLKPDWVLRRDNMEEITNPLQAIQMVMDTLGIPY

ASPM

Abnormal spindle-like microcephaly-associated protein homolog

3476 amino acids

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).

409.558 kDa

MANRRVGRGCWEVSPTERRPPAGLRGPAAEEEASSPPVLSLSHFCRSPFLCFGDVLLGASRTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQPKEKIVISVNWTPLKEGRVREIMTFLVNDVLKHQAILLGNAEEQKKKKRSLWDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENNSLTLEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSLHASENRELLNVHSANVSKVSFNEKAVTETSFNSVNVNGQSGENSKLSLTPNYSSTLNITQSQIHFLSPDSFVNNSHGANNELELVTCLSSDMFMKDNSKPVHLESTIAHEIYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYVCTSQQTCKVPLSNENSQVPQSPEDWRKSEVSPRIPECQGSKSPKAIFEEIVEMKSNYYSFIKQNNPKFSAVQDISSHSHNKQPKRRPILSATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKDFHSYLPIIDPILSKSKSYKNEVAPSSTTASVARKRKSDGSMEDANVRVAVTEHTEVREIKRIHFSPSEPKTSAVKKTKNVITPISKHISNREKLNLKKKTDLSIFRTPISKTNKRTKPIIAVAQSNLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLGIENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYRDGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQKMHNVDVVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDDLINKKKGKRDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHENTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQLAVINFLAKQRLRKRVNAALVIQKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRRRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLVIQSMFRKWKQRKMQSQVKATVILQRAFREWHLRKHAKEENSAIIIQSWYRMHKELQKYIYIRSCVVIIQKRFRCFQAQKLYKRKKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLCRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKLQAHVRKHQQRQKYKKMKKAAVIIQTHFRAYIFARKVLASYQKTRSAVIVLQSAYRGMQARKMYVHILTSVIKIQSYYRAHVSKKEFLSLKNATIKLQSIVKMKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRKAVISLQSYFRMRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQSIIKIQRWYRAYKTLHDTRTHFLKTKAALISLQSAYRGWKVRKQIRREHQAVLKIQSAFRMAKAQKQFRLFKTAALVIQQNFKAWTAGRKQRMEYIELRHAVLMLQSMWRGKTLRRQLQRQHKCAVIIQSYYRMHVQQKKWKIMKKAALLIQKYYRAYSIGREQNHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITNHQHKEYLNLKKTAIKIQSVYRGIRVRRHIQHMHRAATFIKAVFKMHQSRISYHTMRKAAIVIQVRFRAYYQGKTQREKYLTILKAVKILQASFRGVRVRRTLRKMQIAATLIQSNYRRYRKQTYFNKLKKITKTVQQRYRAMKERNIQFQRYNKLRHSVIYIQAIFRGKKARRHLKMMHIAATLIQRRFRTLMMRRRFLSLKKTAILIQRKYRAHLCTKHHLQFLQVQNAVIKIQSSYRRWMIRKRMREMHRAATFIQATFRMHRLHMRYQTLKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKTRRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHKLHQFLHLRKAAITIQSSYRRLMVKKKLQEMQRAAILIQATFRMHRTYTTFQTWKHASILIQQHYRTYRAAKLQRENYIRQWHSAVVIQAAYKGMKARHLLREKHKASIIIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKKQKAFQHNELKKETCVQAGFQDMNIKKQIQEQHQAAIIIQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKDIQNMHQAATLIQSFYRMHRAKVDYETKKTAIVVIQNYYRLYVRVKTERKNFLAVQKSVRTIQAAFRGMEVRQKLKNVSEEKVAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKASGLACSQEAEYHSQSRAAVTIQKAFCRMATRKLETQKYAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQAMWRRYRAKKYLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTRFLNVRASAIIIQRKWRAILSAKIAHEHFLMIKRHRAACLIQAHYRGYKGRQVFLRQKSAALIIQKYIRAREAGKRERIKYIEFKKSTVILQALVRGWLVRKRILEQRAKIRLLHFTAAAYYHLNALRIQRAYKLYLAMKHANKQVNSVICIQRWFRARLQEKRFIQKYHSVKKIEHEGQECLSQRNRAASVIQKAVRHFLLRKKQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLYKRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAHSGAISKIFVLIRSCNRSVPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDILLELLQIYREKPGNKVADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIYSLYKLTAHKHKMNTERILYKQKKNSSISIPFIPETPVRTRIVSRLKPDWVLRRDNMEEITNPLQAIQMVMDTLGIPY

ASPM

Abnormal spindle-like microcephaly-associated protein homolog

3476 amino acids

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).

409.426 kDa

MANRRVGRGCWEVSPTERRPPAGLRGPATEEEASSPPVLSLSHFCRSPFLCFGDVLLGDSRTLPLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQPKEKIVISVNWTPFKEGRVREIMTFLVNDVLKHQAILLGNAEKQKKKKRSLWDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENNSLTLEENKIPISPISPAFNECHGATCLPLSVRRSTTYSSLHASENRELLNVDSANVSKVSFNEKAVTETSFNSINVNDQSGENSKLILTPNYSSTLNITQSQINFLSPDSFVNNSHGANNELELVTCLSSDMFMTDNSKPVPLQSTIAHEIYQKILSPDSFIKDNYGLNQDLESESVNPILSPNQFLKDNMAYMCTSQQTYKVPLSNENSQVPQSPQDWSKSEVSPCIPEYQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSAVQDISSHSHDKQPKRRPILSATVTKRKPTCTRENQTEINKPKAKRCLNSAVGEHEKVIHNQKEKEDFHSYLPVIDPVLSKSKSYKNQIMPSLTTASVARKRKSDGSMEDANVRVAVTEHTEEREIKRIHFSPSEPKTSAVKKTKNVITPISKCISNREKLNLKKKTDLLIFKTPISKTSKRTKPIIAVAQSNLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLGVENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETIYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYRDGHEGALSKFTLKKLLLLICFLDYAKISXLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDEFDFAITNLAVDLQCGVRLVRTMELLTQNWNLSKKLRIPAISRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDALINKKKGKRDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPXDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHENTSELYKELLENEKKNFQLIRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQERDKAARIIQSAVINFLAKQRLRKRVNAALIIQKYWRRVLAQRKLLILKKEKLEKVQNKAASLIQGYWRRYSTRKRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSSLIIQSMFRKWKRRKMQSQVKATVILQRAFREWHLRKRAKEENSAIVIQSWYRMHKELRKYIYIRSCVIVIQKRFRCFQAQKLYKRKKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLCRQIRAACVIQSYWRMRQDRVRFLNLKKTIIKLQAHIRKHQQVQKYKKMKKAAVIIQTHFRAYIFTRKVLASYQKTRSAVIVLQSAYRGMQARKVYIHILTSVIKIQSYYRAYVSKKEFLSLKNTTIKLQSIVKMKQTRKQYLHLRAAALFIQQCYRSKKITTQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRKAVISLQSYFRMRKARQYYLKMCKAIIVIQNYYHAYKAQVNQRKNFLRVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRVKYQSVLQSIIKIQRWYRAYKTLHDTRTRFLKTKAAVVSLQSAYRGWKVRKQIRREHQAALKIQSAFRMAKAQKQFRLFKTAALVIQQNFRAWTAGRKQRMEYIELRHAVLILQSMWKGKTLRRQLQRQXKCAIIIQSYYRMHVQQKKWKIMKKAALLIQKYYKAYSIGREQHHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITHXXHQEYLNLKKTAIKIQSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRFRAYYQGKMHREKYLTILKAVKILQASFRGVXVRWTLRKMQIAATLIQSNYRRYKQQTYFNKLKKITKTIQQRYRAVKERNIQFKRYNKLRHSVIYIQAIFRGKKARRHLKMMHVAATLIQRRFRTLMMRRRFLSLKKTAVWIQRKYRAHLCTKHHLQFLQVQNAVIKIQSSYRRWMIRKKMREMHRAATFIQATFRMHRVHMRYQALKQASVVIQQQYXANRAAKLQRQHYLRQRRSAVILQAAFRGVKTRRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHKLHQFLQLRKAAITIQSSYRRLMVKKKLQEMQRAAVLIQATFRMHRTCVTFQTWKQASILIQQHYRTYRAAKLQKENYIRQWHSAVVIQTAYKGMKARQHLREKHKAAIIIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKKQKALQHNELKKETCVQASFQDMNIQKQIQEQHQAAIIIQKHCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRRDIQNMHRAATLIQSFYRMHRAKVDYQTKKTAIVVIQNYYRLYVRVKTERKSFLPVQKSVRTIQAAFRGMKVRQKLKIVSEEKMAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKASDLACSQEAECHSQSRAAVTIQNAFRRMVTRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQAMWRRYRAKKYLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTWFLNVRASAIIIQRKWRAILSAKIAHEHFLMIKRHRAACLIQAHYRGYKERQVFLRQKSAALIIQKYIRAREAGKRERIKYIEFKKSTVILQALVRGWLVRKRILEQKTKIRLLHFTAAAYYHLNALRIQRAYKLYLAVKNANKQVNSVICIQRWFRARLQQKKFIQKYSIKKIEHEGQECLSQQNRAASVIQKAVRHFVLRKKQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLYKRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIFVLIRSCNRSVPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDTLLELLQIYREKPGNKVADKGGSIFTKTCCLLAVLLKTTNRASDVRSRSKVVDRIYSLYKLTAHKHKMNTERILHKQKKNSSISIPFIPXTPVRTRIVSRLKPDWVLRRDNMEEITNPLQAIQMVMDTLGIPY

ASPM

Abnormal spindle-like microcephaly-associated protein homolog

3471 amino acids

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).

409.369 kDa

MANRRVGRGCWEVSPTERRPPAAEEEASSPPVLSLSHFCRSPFLCFGDVLLGASRTLSLALDNPNEEVAEVKISHFPAADLGFSVSQRCFVLQPKEKIVISVNWTPFKEGRVREIMTFLVNDVLKHQAILLGNAEEQKKKKRSLWDTIKKKKISASTSHNRRVSNIQNVNKTFSVSQKVDRVRSPLQACENLAMNEGGPPTENNSLTLEGNKIPISPISPAFNECHGETCLPLSVRRSTTYSSLHASENRELLNVDSASVSKVSFNEKAVTETSFNSINVNGQSGENSKLSLTPNYSSTLNITQSQIHFLSPDSFVNNSHGANNELELVTCLSSDMFMKDNSKPVHLESTIAHEIYQKILSPDSFIKDNYGLNQDVESESVNPILSPNQFLKDNMAYMCTSQQTCKVPLSNENSQVPQSPQDWRKSEVLPRIPECQGSKSPKAIFEELVEMKSNYYSFIKQNNPKFSVVQDISSHSHNKQPKRRPILSATVTKRKATCTRENQTEINKPKAKRCLNSAVGEHEKVINNQKEKEDFHSYLPIIDPILSKSKSYKNEVTPSSTTASVARKRKSDGSMEDADVRVAVTEHTEVREIKRIHFSPSEPKTSAVKKTKNVITPISKRISNREKLNLKKKTDLSIFKTPISKTNKRTKPIIAVAQSNLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLGIENQHKISVPRAPTKEEMSLRAYTARCRLNRLRRAACRLFTSEKMIKAIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETTYGELISLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPHLYRDGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKDIVDRHREKTLRLLWKIAFAFQVDISLNLDQLKEEIAFLKHTKSIKKTISLLSCHSDDLINKKKGKRDSGSFEQYSENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTQTGSVVLNSSSESDDSSLDMSLKAFDHENTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQEREKAARIIQSAVINFLAKQRLRKRVNAALVVQKYWRRVLAQRKLLMLKKEKLEKVQNKAASLIQGYWRRYSTRRRFLKLKYYSIILQSRIRMIIAVTSYKRYLWATVTIQRHWRAYLRRKQDQQRYEMLKSSTLIIQSMFRKWKRRKMQSQVKATVILQRAFREWHLRKQAKEENSAIVIQSWYRMHKELRKYIYIRSCVVIIQKRFRCFQAQKLYKRKKESILTIQKYYKAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLCRQIRAAGVIQSYWRMRQDRVRFLNLKKTIIKLQAHVRKHQQLQKYKKMKKAAVIIQTHFRAYIFARKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSIVKVKQTRKQYLHLRAAALFIQQCYRSKKIAAQKREEYMQMRESCIKLQAFVRGYRVRKQMRLQRKAVISLQSYFRMRKARQYYLKMYKAIIVIQNYYHAYKAQVNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQSIAALKIQSAFRGYNKRIKYQSVLQSIIKIQRWYRAYKTLHDTRTHFLKTKAAVISLQSTYRGWKVRKQIRREHQAALKIQSAFRMAKARKQFRLFKTAALVIQQNFRAWTAGRKQRMEYIELRHAVLMLQSMWKGKTLRRQLQRQHKCAIIIQSYYRMHVQQKKWKIMKKAALLIQKYYRAYSIGREQNHLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAVTIQSKYRAYKTKKKYATYRASAIIIQRWYRGIKITNHQHKEYLNLKKTAIKIQSVYRGIRVRRHIQHMHRAATFIKAMFKMHQSRISYHTMRKAAIVIQVRFRAYYQGKMQHEKYLTILKAVKILQASFRGVRVRRTLRKMQIAATLIQSNYRRYRQQTYFNKLKKITKTVQQRYRAMKERNIQFQRYNKLRHSVIYIQAIFRGKKARRHLKMMHIAATLIQRRFRTLMMRRRFLSLKKTAIWIQRKYRAHLYTKHHLQFLRVQNAVIKIQSSYRRWMIRKRMREMHRAATFIQAIFRMRRLHMRYQALKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKTRRHLKSMHSSATLIQSRFRSLLVRRRFISLKKATIFVQRKYRATICAKHKLHQFLHLRKSAITIQSSYRRLMVKKKLQEMQRAAVLIQATFRMHRTYITFQTWKHASILIQQHYRTYRAAKLQRENYIRQWHSAVVIQAAYKGMKARQLLREKHKAAIIIQSTYRMYRQYCFYQKLQWATKIIQEKYRANKKKQKAFQHNELKKETCVQAGFQDMNIKKQIQDQHQAAIIIQKNCKAFKIRKHYLHLRATVVSIQRRYRKLTAVRTQAVICIQSYYRGFKVRKDIQNMHRAATLIQSFYRMHRAKVDYQTKKTAIVVIQNYYRLYVRVKTERKSFLAVQKSVRTIQPAFRGMKVRQKLKNLSEEKMAAIVNQSALCCYRSKTQYEAVQSEGVMIQEWYKASGLACSQEAEYHSQSRAAVTIQKAFCRMATRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAITLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARSKGFIQKRKFQEIKNSTIKIQAIWRRYRAKKYLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGCFYTKLERTRFLNVRASAIIIQRKWRAILSAKIAHEHFLMIKRHRATCLIQAHYRGYKGRQVFLRQKSAALVIQKYIRAREAGKRERIKYIEFKKSTVILQALVRGWLVRKRILEQRAKIRLLHFTAAAYYHLNALRIQRAYKLYLAVKNANKQVNSVICIQRWFRARLQRKRFIQKYHSIKKIEHEGQECLSQQNRAASVIQKAVRHFLLRKKQEKFTSGIIKIQALWRGYSWRKKNDCTKIKAIRLSLQVVNREIREENKLYKRTALALHYLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAISKIFVLIRSCNRSVPCMEVIRYAVQVLLNVSKYEKTTSAVYDVENCIDILLELLQIYREKPGNKVADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIYSLYKLTAHKHKMNTERILYKQKKNSSISIPFIPETPVRTRIVSRLKPNWVLRRDNMEEITNPLQAIQMVMDTLGIPY

ASPM

Abnormal spindle-like microcephaly-associated protein homolog

3469 amino acids

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).

408.504 kDa

MATRRVGRGCWEVSPTERRPCAGLRGPAAEEEAASPPVLFLSHFCRSPFLCFGDVRLGTSRTLPLTLDNPNEEVAEVEISHLPAADLGFSVSQRRFVLQPKEKIVISVNWTPFKEGRVRETMTFLVNDVLKHQAILLGNAEEQKKKKRNLWDTIKKKKISASTSHNRRVSNIQNVKTFSVSQKVDRVRSPLHACENLAMNEGGPPTENNHLTLEENKILISPISPAFSECHGATCLPLSVRRSTAYSSLHALENRELLNVDSANVSKDNFNEKVVSETSFNSINVSDQSGENNKLILTPNYSSTLNITQSQRNFLSPDSFVNNSHGENNELELGTCLSSDMFMKDNPKPMLLESTTAREMYQKILSPDSFIKDNYGLNQNLESESVXSILSPNQMACMCTSQQTYKVPSSNENSQVPQSLQDWRKSKVFPCVPECQGSKSPKATFEELVEMKSNCCSFIKQNQPKFPAVKDISSHSHNKQPKRRPILSATVTKRKPTRTRENQTEINKPKAKRCLNSAVGENEKIINNQKEKEDFYSYLPIIDPVLSKSKSYKNEITPSLTTASVARKRKSDGSMGDANERVAVTEHTEVQEIKRIHFSPSEPKTATVKKTKNVITPISKCVSNREKLSLKKKTEFKTPIFKTSKRTKPIIAVAQSNLTFIKSLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLGVENQHKISVPRAPTKEEMSLRAYTARCMLNRLRRAACRLFTSEKMVKAIKKLEIEIEARRLVVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETVYGELISLEDNSDVTGLAVFILSRLLWNPDIAAEYRHPTVPHLYGDGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASKEILLAFSRDFLSGEGDLSRHLGLLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRTMELLTQNWDLSKKLRIPAISRLQKMHNVDIVLQVLKSRGIELSDEHGNTILSKNIVDRHREKTLGLLWKIVFAFQVNISLNLDQLKEEIAFLKHTKSIKKTVSLLSCHSDALTNKKKGKRDSGSFEQYGENIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAISQRTTQTVECTHTGSVVLNSSSESDESSLDMSLKAFDQENTSELYKELLENEKKNFHLVRSAVRDLGGIPAMINHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKTDLKRHQERDKAARIIQSAVINFLRKQRLRKTLNAALIIQKYWRRVLAQKKLLMLKKEKLERVQNKAASLIQGYWRRYSTRKRFLKLKYYSIVLQSRIRMIIAVTCYKRYLWATVTIQRHWRASLRRKQDQQRYEKLKSSSLIIQAMFRRWKQRKMQLQVKATITLQRAFREWHLRKRAKEEKSAIVIQSWYRMHKQLRKYVYVRSCVVIIQKRFRCFQAQKLYKRRKESILTIQKYYRAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHNLHRQIRAACVIQSYWRMRQDRVRFLNLKKIIIKLQAHVRKHQQLRKYKKMKKAAVIIQTHFQAYIFARKVLASYQKTRSAVIVLQSAYRGMQARKMYIHILTSVIKIQSYYRAYVSKKEFLSLKNATIKLQSIVRMKQTRKQYLHLRATALFIQQCYHSKKLAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRKAVISLQSYFRMRKSRQYYLKMYKAVIIIQNYYHSYKAQVNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQSVAAVKIQSAFRGYSKRVKYQSVLQSIIKIQRWYRAYKTLHGIRTHFLKTKAAVISLQSAYRGWKVRKQIRREHQAAMKIQSAFRMAKAQKQFRLFKTAALVIQQHLRAWTAGRKQRMEYIELRHSVLMLQSMWKGKALRRQLQRQHKCAVIIQSYYRMHVQQKKWKIMKKAALLIQKYYRAYSIGREQHCLYLKTKAAVVTLQSAYRGMKVRKRIKDCNKAAITIQSKYRAYKTKKKYAAYRASAIIIQRWYRSIKITNHQYKEYLNLKKTAIKIQAVYRGIRVRRHIQCMHRAATFIKAMFKMHQSRIRYHTMRKATIVIQVRYRAYYQGKMQREDYLKFLKAVNVLQANFRGVRVRRTLRKLQIAATVIQSNYRRYRQQTYFNKLKKITKTVQQRYRAVKERNIQFQRYNKLRHSVIHIQAIFRGMKVRRHLKTMHIAATLIQRRFRTLMMRRRFLSLKKTAIWIQRKYRAHLCTKHHLQFLRLQNAAIKIQSSYRRWVVRKKMREMHRAATFIQATFRMHRVHMRYQALKQASVVIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMETRRRLKSMHSSAILIQSRFRSLLVRRRFISLKKAAIFIQRKYRATICAKHNLHQFLQLRKAAVTIQSSYRRLMVKKKLQEMHRAAVLIQATFRMHKTYITFQTWKHASILIQQHYRTYRASKLQRENYTKQWHSALIIQAAYRGMKARQLLREKRKAAIIIQSTYRMYRQYCLYQNLQWATKIIQEKYRANKKKHKALQHNELKKAEACVQASFQDMNIKKLIQEQHQTSLTIQKHCNAFKIKKQYLHLRAPVVSIQRRYRKLTAVHTQAVICIQSYYRGFKVRRDIQNMHLAATRIQSLYRMHRAKVDYQTKKTAIVVIQNYYRLYVRVKTERNSFLAVQKSVRTIQAAFRSMKVRQKLKNLSQEKMAAIVSPSAVYCYRIEAQSEAVGSEGVIIQEWYKTSCLAHSQEAEYHSQSRAAVTIQKAFRRMITRKLETQKCAALRIQFFLQMAVYRRRFVQQKRAAVTLQHYFRTWQTRKQFLLYRKAAVVLQNHYRAFLSAKHQRQVYLQIRSSVIIIQARTKGFIQKRKFQKIKNSTIKIQAVWRRYRDKKSLCKVKAACKIQAWYRCWRAHKEYLAILKAVKIIQGSFYXKLERTRFLNMRASAIIIQRKWRAILSAKIAHEHFLMIQRHQAACLIQAHFRGYKGRQVFLRQKSAALNIQKYIRAREAGRRERIKYIELKKSTVTLQALVRGWLVRKRILEQRAKIRLLHFTAAAYYHLKALRIQRAYKLYLALKNANKQVNSAICIQRWFRARLQQKRFIQICHSIKKIEHEGQERLSQQNRAASVIQKAVRHFLLRKKQEKFTSGIIKFQALWRGYSWRKNNDCTKIKAIRLSLQVVNREIREENKLYRRAALALHYLLTYKHLSAILEAVKHLEVVTRLSPFCCENMAQSGAISKIFVLIRSCNRSVPCMEVIRYAVQVLLNVAKYEKTTSAVYDVENCVDTLLELLQMYREKPGNKVADKSGSIFTKTCCLLATLLKTTNRASDVRSRSKVVDRIYSLYKLTAYKHKVNTERLHYKQKKDSSTSIPFIPETPVRTRIVSRLKPDWVLRRDNLEEITNPLQAIQMVMDTLGIPY

ASPM

Abnormal spindle-like microcephaly-associated protein homolog

3461 amino acids

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).

406.398 kDa

single

MATRRAGRSWEVSPTERRPSARPRNSAAEEAAASPPVLSLSHFCRSPFLCFGDVRLGASRTLPLALDNPNEEVAEVKIAHFPAAEQGFSISPRSFELQPKEKIIISVNWTPLKEGRVREIVTFLVNDILKHQAILLGNAEEKKKKKRSLWDTINKKKMSTSSSDKRNSYIQNVNTTFCVSQKADRVRSPLQACENLAMKEGCFLTENNSLSLEENKIPISPISPIFKECHGETSLPLSVRRSTTYTSLHACENGELLKVEGADGSEDFNFNEKVTSETSFSSIHNMSGQIEENSKLILTPTCCSTLNITQSQGNFLSPDSFVNNSHAANNEPEVATCLSLDTFRKDNSSPVHLESKTVHKTYRTILSPDSFINDNYGLNQDLEPESINPILSPNQFVKDNMAYICISQQTCKLSSLSNKNSQVSQSPQDQRTNGVLPCFRECQGSQSPEAIFEESRTLEMKSDCYSFTKNQPKFPVIQNISSYSHDKRTRRPILSATVTKSKSICSRENQTEANKPKAKRCLNSVAGEFEKPTDTQNEKSGFQSCLPVIDPVFSKSKSYKNAVIPSSKTALVARKRKSEGNKEDANVRVTVTEHTEVREIKRIHFSPVESKMATVKKTKKMITPISKHISYREKSNLRKKTDSLVYRTPHSKTNKRTKPVVAVAQSTLTFIKPLKTDIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNAATLLLGVESQHKISVARAPTKDEMSLRAYTARCRLNRLRRAACRLFTSENMVKAIKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETIYGELISLEDNSDVTGLAVFILNRLLWNPDIAAEYRHPSVPHLYRDGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKTSKEILLAFSRDFLSGEGDLSRHLSFLGLPVNHVQTPFDEFDFAVTNLAVDLQCGVRLVRIMELLTRDWNLSKKLRIPAISRLQKMHNVDIVLQILRSRGIQLNDEHGNAILSKDIVDRHREKTLTLLWKIAFAFQVDISLNLDQLKEEIDFLKHTQSLKKTTSALSCHSDAIINKEKDKRNSGSFERYSESIKLLMDWVNAVCAFYNKKVENFTVSFSDGRVLCYLIHHYHPYYVPFDAICQRTTQTVECTQTGSVVLNSSSESDGSSLDLSLKALDHENTSELYKELLENEKRNFQLVRSAVRDLGGIPAMIHHSDMSNTIPDEKVVITYLSFLCARLLDLCKETRAARLIQTTWRKYKQKTDLKRHQERDKAARIIQSAVISFLSKQRLKKEINAALAIQKHWRRLLAQRKLLMLKKEKLEKVQNKSALVIQRYWRRYSTRKQFLKLKYYSVILQSRIRMILAVTSYKRYLWATVTIQRHWLAYLRRKRDQQRYEMLKSSCLIIQSVFRRWKQHKMRLQIKATIILQRAFREWHVRKRAKEEKSAVVIQSWYRMHKELRKYIHLRSCVVIIQTRFRCLQAQKSYKRRREAILTIQKFYRAHLKGKTERANYLQKRAAAIQLQAAFRGMKARNLHRQIRAACVFQSYWRMRRDRFRFLNLKKITIKLQAQVRMHQQLQKYKKIKKAALIIQIHLRASVLAKRALASYQKTRSAVIVLQSAYRGMQARRKFIHILTSIIKIQSYYRAYISRKKFLRLKHATVKLQSIVKMKQTRKQYLHLRAATLFIQQWYRSIKVAALKREEYVQMRESCIKLQAFVRGHLVRKQMRSQRKAAVSLQSYFRMRKMRQHYLEMYKAAVVIQNYYRAYKAQVSQRKNFLQVKRAVTCVQAAYRGYKVRQLIKQQSIAALKIQTAFRGYSKRKKYQYVLQSTIKIQTWYRTYRTVRDVRMQFLKTKAAVISLQSAYRGWKVRTQIRRELQAAVRIQSAFRMAQTQKQFRLFKTAALVIQQHLRAWSAGKKQRMEYTELRNAALMLQSTWKGKIVRRQIRKQHKCAVIIQSYYRMHVQQKKWDIMKKAARLIQMYYRAYRIGRRQRQLYLKTKAAIVIIQSAYRSMRVRKKIKEYNKAAVAIQSTYRAYKAKKNYATYRASAVLIQRWYRNIKIANRQRKEYLNLKKTAVKIQAVFRGIRVRRRIQHMHTAATFIKAMFKMHQAKVRYHKMRTAAVLIQVRYRAYCQGKIQRAKYLTILKAVTVLQASFRGVRVRQTLRKMQNAAIRIQSCYRRYRQQTYFNKLKKVTQTVQQRYRAVKERNVQFQRYNKLRHSAICIQAGFRGMKARRHLRMMHLAATLIQRRFRTLKMRRRFLSLRKTALWVQRKYRATVCAKHHLQQFLRLQKAVITLQSSYRGWVVRKKMQEMHRAATVIQAAFRMHRAHVRYQAVRQASVVIQQRHQANRAAKLQRQRYLRQRHSALILQAAFRSMKARRHLKMMHSSAVLIQSRFRGLVVRKRFVSLKKAAVFVQRRYRATTCARRHLHQFLKVQKAVITIQSSYRRLMAKKKVQAMHRAAALIQATYKMHRTYVTFQAWKHASILIQQHYRIYRAAKLQRENYVRQRHSALVIQAAYKGMKARQLLREKHRAAIIIQSTYRMYRQYLFYRKIQWATKVIQKIYRAKKRKALQHDALRKVAACVQADFQDMIIRKQIQEQHQAATVLQKHLKASKVRKHYLHFRAKVVFVQRRYRALSAVRTQAVICIQSSYRGFKVRKGIQRMHLAATLIQSLYRMHRAKLDYRAKKTAVVLIQYYYRSYVRVKTERKNFLALQKSVRIIQAAFRGMKVRQKLKNLSEAKMAAIEKRSAFCRHRTETPYEAVQSSALRIQKWHRASLVACSQEAECHSQGRAAVTIQKAFCKTATEILETQKHAALRIQSFLQMAVYRRRFVQQKRAAVTLQQYFRTWQARKQFLLYRKAASVLQNHHRGFLSAKPQREAYLHVRSSVIIIQARTRGFIQKRKFQKIKDSTIKIQAAWRSYKARKYLCKVKAACKIQAWYRSWKARKEYLAILKAVKVIQGCFYTKLERTRFLNMRASTIIIQRKWRAMLSGRIAHEHFLMIKRHQAACLIQANFRRYKGRQVFLRQKSAALTIQRYIRARKAGKCERIKYVELKKSTVVLQALVRGWLVRKRISEQRTKIRLLHFTAAAYCHLSALRIQRAYKLHMVMKNAKKQVNSVICVQRWFRTRLQQKRFAQKCHSVIKSQRELQEHMSQQNRAASVIQKAVRRFLLRKKKEKINNGITKIQALWRGYSWRKKNDGTKIKAIRLSLQLVNREIREENKLYKRTALALHCLLTYKHLSAILEALKHLEVVTRLSPLCCENMAQSGAVSKIFVLIRSCNRSVPCMEVIRYSVQVLLNVAKYEKTTAAVYHVENCIDTLLDLLQMYREKPGDKVADKGGSIFTKTCCLLAILLKTTNRASDVRSRSKVVDRIYSLYKLTARKHKMNTERILYTQKKNSSISIPFIPETPIRTRIVSRLKPDWVLRRDNMEEIT

ASPM

Abnormal spindle-like microcephaly-associated protein homolog

3374 amino acids

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).

395.702 kDa

single

PNEEAAAVRLSRGPAAERGFTIWPXAFVLQPKEKIVVSITWTPLKGGRVRETVTFLVNDILKHQAILLGNAEEPKKKKRTLWDTINKKKVSASSRHNKKVSNIQNVNKTFNVSPKADKVRSPLQACENLATNGNCSPPESNPLILEENKLPISPISPAFQECHRETCLPLHVRRSTTYTSLPASENGELEKADGANTAKDFHFNEKGITETSFDSIDNVNSQTEENGKLTLTPNYSSSLNITQSQGHFLSPDSFVNNSHASNNEPEFVKCLSPDMFVKGNTRPVLLESKRVHEICRKILSPDSFINDNYGLNEDLETESVNPILSPNQFLKDNIAYICISQQTCQLPLSTRRFQDSQPPQDERKNAAVPCISECQQLESPKATFEASKALEVMSNSYTFKKQNQPKFSAVQDISSHSREKPIKRRPILSATVTKRKPTCAVXNQMETVKPKAKRCLNVVVGDCEKETDDQKEKDDFHPLLPTRDLILSRPKSSKNIVTPPCKAASVARKRKSKGHTGDENVRVRVTECSEVQEVKRTHFSPLASKTSTVKHTHKVLTSSLKRVSHREKVNLKRKTDSLGYRTPTSKTNKRTRPFVPVAQSNLTFIKALKAGIPRHPMPFAAKNIFYDERWKEKQEQGFTWWLNFILTPDDFTVKTNISEVNASTLLLGVESQHKISVPKAPTKDEVSLRAYTARCRLNRLRRAACRLFTSEKMVKAMKKLEIEIEARRLIVRKDRHLWKDVGERQKVLNWLLSYNPLWLRIGLETIYGELVPLEDNSDVTGLAMFILNRLLWNPDIAAEYRHPSVPHLYRDGHEEALSKFTLKKLLLLVCFLDYAKISRLIDHDPCLFCKDAEFKASXDILLAFSRDFLGGEGDLSRHLSLLGFPVTHVQMPFDEFDFAVKNLAVDLQCGVRLVRTMELLTQNWNLSKKLRIPAISRLQKMHNVDIVLEILKSRGIQLNDEHGNAILSKDIVDRHREKTLALLWKIALAFQVDISLNLDQLKEEIDFLKKTQSMKKTMSALLCRPDAVISKKRDERHSGPFEQYSESVKLLMDWVNAVCGFYNKKVENFTVSFSDGRVLCYLIHHYHPCYVPFDAICQRTTQTVECTHTGSVVLNSSSESDGSFLDLSXKSPDQENTSELYKELLENEKKNFQLVRSAARDLGGIPAMIHHSDMSNTIPDEKVVITYLSFLCARLLDLRKETRAARLIQTTWRQYKLKKDLKHHQERDKAARIIQSAIINFLTKQRFKKKVSAALVIQKYWRRALAKRKLLMLKKEKLERVHSKSASIIQRYWRRYSTRKQFLKLKYYSIILQSKIRMIIAVASYKRYHWATVTIQXHWRAHVRSKQDRQRYELLRSSTLVIQSAFRRWRRHKRQSQINAAITLQRAFREWRVQKRAQEERAAVVIQSWYRMHRESQKYIHLRSCVIIIQARFRCFQAQKLYTRTRESILTLQKHYRAYVKGKVERTGYLQKRAAAIRLQAAFRGRRARNLCKQIRAACVLQSCWRMRQDRLRFLNLKKNIIRLQAHIRRRQQLQTYQKMKKAALVIQIHFRAYISAKEVLASYQKTRSAVIVLQSACRRMQARKKFLHILTAVVKIQSYYRAYASRRKFLRLKKATVKLQSIVRMKQARKQYLHLRAIAQQREEHLRASCIKLQAFLRGYLVRKQVRLQRKAAVLLQSYFRMRKMRLEYLKVCQAAVVIQRYYRAHRAGAQQRKHFLQVRRAVTCLQAAYRGYKVRRQLQQQSAAALKIQAAFRGYRQRTKYQSMLQSALKIQRWYRTRKMVSALRSHFFKTRTAAISLQSAYRGWKVRKQMRKEHEAAVKIQSAFRTARAQKEFRLLKTAASVIQQHLRARATGLRQRTEYMALRRAAVTLQSAWRGRAARRRIQKQQRCAIIIQACYRRHVQWKRWEIMKKAARLIQMHYRAYRTGRKQHHLFLKTKGAAIILQSAFRGVRARKKVKEMHQAATTIQSRYRAYQARKKYASYRAAAVIIQRWYRAAKLAGCQREEYLAVKKAALKIQAVYRGVRERRQTRRMHMAATLIKAAFKMQQSRRRYQQMRTAAIVIQVRYRAYRQGRAQRAKYLTTLKAVALLQAALRGARVRQNLRRMRTAATLIQAHYRGRRQQAYFNKLKKVTKTVQQKYRAGRERHAQLRRYNQLRRSAICIQAAFRGMRARKRLKAMHSAAAVIQRRFRTLVMRRRFLSLRKTAVWVQRKYRAKVCARHHLQQLQLQKAAIKIQSWYRGWMVRKKTQEMRRAATVLQAAFRRHRARARYQAWRRASQVIQQRFRAGQAARLQRRQYLQQXRSALVLQAAFRGMRIRRRLKRMHASATLIQSRFRSVRVRKRFLSLKKAAVFVQRKYRATICAKHHLQRFLELKKAIIIIQAFYRRRMVKKQLQEMHRAAALIQASFRMHRARLAFQTWKLAXVLIQQHYRAYRAAKLQRALYIRWRHSAVVIQAAYKGLKARQLLREKHRAAVIIQSTYRMYRQHFSYQKLQWATKVIQERYRVSKRKALQHDALKAAACARADFQDMVIRGLIQERQHQAAITVQKHFRAFKTRKRYLHFRAKVVFVQRRYRVLMAVRTQAAICIQSCFRGFKARRGIQGMHLAATRIQSCYRRHRARADYQAKKRAVVVIQNHYRSYVRVKMERKEFLAIQKSARTIQAAFRGMKVRQKLKTMPDEKMAAPATRPAFYCHRTESQHEAGQSPALVAQGLYKTSLVGPSQETEHHSQRKAAVTIQKAFRKMVTRRLEKQRSAAVQIQSFLQMAVYRRRFLQQKRAALTLQRYFRTQQSRKRFLLYREAAVGLQNPHRAFLPAKHQRELYSQIRSSVIIIQARVKGFIQKRKFRKLKDSTIKIQAVWRRHKARKYLREVKAACRIQAWYRCRKARKEYLAVLRAVRIIQRCFCTQQQRRRFLNVRASAVIIQRRWRAVLSGRTTHEQSLMTKRHQAACLIQANFRGYKARQVFLQQKSAALTIQRFIRARKAGKHQRMKYVELKKSTVVLQALVRGWLVRKRISEQRAKIRLLHFAAAAFYHLSALRIQRAYRRHMALKNANNKQLNSAICIQRWFRARSQRKRFLQKYSIVNIQREAREQASQHSRAASVIQRAVRHFLLRKKQENLNKRIAKIQALWRGYSWRKKNDTSKTKAIRQRLQCVNREIREENKLYHRTVFALHHLLTYKYLSTVLEALKHLEAVTRLSSVCCEKMAQSGAISKVFVLIRSCNRSVPCMEVIRYAVQVLLNVAKYEKTTSAIYBVENCVDTLLELLQMYQEKSGDKVADKSRSIFTKTCCLLAVLLKTTTRASDVQSRSKVVDRIYSLYKLTAHKHKVNTERILCKQKKNSSVSLSFFPETPVRTRMVSRLKPDWVLRRDNV

Aspm

Abnormal spindle-like microcephaly-associated protein homolog

3122 amino acids

Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seem to depend on its association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.

364.218 kDa

MATMQAASCPEERGRRARPDPEAGDPSPPVLLLSHFCGVPFLCFGDVRVGTSRTRSLVLHNPHEEPLQVELSLLRAAGQGFSVAPNRCELKPKEKLTISVTWTPLREGGVREIVTFLVNDFLKHQAILLGNAEEPKKKKRSLWNTSKKIPASSKHTKRTSKNQHFNESFTISQKDRIRSPLQPCENLAMSECSSPTENKVPTPSISPIRECQSETCLPLFLRESTAYSSLHESENTQNLKVQDASISQTFDFNEEVANETFINPISVCHQSEGDRKLTLAPNCSSPLNSTQTQIHFLSPDSFVNNRYTSDNDLKSMKNVLSDTFRKDPAESVCLESQTVHEVCQTILSPDSFLNDNYGLKKGLNFKSVNPVLSPTQFVKDSMGHVGQQTGKSNEASQDWRINEGLAYTPECQHAQTPSSRSEKQNPVEVKPHTYDFTKQKPKISEFQDAFCHQSKQPHKRRPILSATVTKRKPTNAREKLPEINKPDAKRCLEGLVGERGKEVGSLREKGFHSSLPVVEPGVSKALSYRDEVTPATVVVARKRKSHGTVGDANGKVAAEEWMDMCEVKRIHFSPLESTPSTVARTTKKEGHTSKRISSLERSGLKKKMDSSILKTPLSKTKKKRRSIVAVAQSHLTFIKPLKAAIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNYILTPDDFTVKTNVSKVNAASLVLGAESQHKISVPKAPTKEEVSLRAYTASCRLNRLRRTACSLFTSEKMVKAIKKVEIEIEVGRLLVRKDRHLWKDIGQRQKVLNWLLSYNPLWLRIGLETVFGELIPLADNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPLLFRDGHEAALSKFTLKKLLLLICFLDHAKISRLIDHDPCLFCKDAEFKASKELLLAFSRDFLSGEGDLSRHLSFLGLPVSHVQTPLDEFDFAVTNLAVDLQCGVRLVRTVELLTQNWNLSDKLRIPAISRVQKMHNVDLVLQVLKSRGVPLTDEHGSAISSKDVVDRHREKTLGLLWKIALAFQVDISLNLDQLKEEIDFLKHTHSIKRAMSALTCPSQAITNKQRDKRISGNFERYGDSVQLLMDWVNAVCAFYNKKVENFTVSFSDGRILCYLIHHYHPCYVPFDAICQRTSQSVACAQTGSVVLNSSSESEGGCLDLSLEALDHESTPEMYKELLENEKKNFHLVRSAARDLGGIPAMIHHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKRDLKHHQERDKAARVIQSVVLNFLSRRRLQKNVSAALVIQKCWRRVSAQRKLRMLKNEKLAKLQNKSAVLIQAYWRRYSTRKRFLRLKHYSVILQSRIRMKIALTSYKRYLWATVTIQRHWRAYLSRKRDQQIFRKLKSSSLVIQFMFRRWKRRKLQLQTKAAVTLQRAFREWHLRKQIRERSAVVIQSWYRMHRELQKYIYIRSCVIVIQRRVRCFQAQKLYKRRKDAILTLQKHYRARQKGKLAHADYLQKRAATIRLQAAFRGMKARHSYRLQIGAACVLQSYWRMRQERVRFLNLKKMVIKLQAHIRKYQQLQKYKKIKKAAITIQTHFRASISARRVLASYQKTRSSVIVLQSACRGMQARKAFRHALASVIKIQSYYRAYICRKTFQNFKNATIKLQSIVKMKQSRKQYLQIRAAALFIQRWYRSQKLASQKRKEYIQVRESCIKLQSHFRGCLVRKQLRLQCKAAISLQSYFRMRTARQRYLKMCKAALVIQSFYCAYRAQISQRKNFLQVKRAAICLQAAYRGCKVRRQIKQQSTAAVTIQRVFRGHSQRMKYQTMLQSAVKIQRWYRAQKVAYDMRIQFLKTREAVVCLQSAYRGWQVRQQLRRQHEAAVKIQSTFRMAVAQQQYKLLRAAAAVIQQHVRARAAGKRQHLAYIQLRHAALVFQAAWKGKMLRRQIARQHQCAALIQSYYRMHIQRRKWSIMKTAALQIQLCYRAYKVGKEQRHLYLKTKAAVVTLQSAYRGMKVRKRVAECHKAAVTIQSKFRAYRTQKKYTTYRTSAIVIQRWYRNIKITTQQHQEYLNLRRAAVQVQAAYRGIRVRRRIQHMHMAATLIEAMFKMRQSRVRYLKMRTAALIIQVRYRAYYLGKIQHEKYLRTLKAIKTLQAGVRGARVRRTVRKMHFAATLIQSHFRGHRQQTYFHRLRKAATMVQQRYRAVKEGSAEFQRYSRLRRSVLLIQAAFRGLRTRRHLKAMHLAATLIQRRFRTFAMRRKFLSLRKTAIWIQRQYRARLYAKYSRQQLLLEKAVIKIQSSYRGWVVRKRVQKMHRAATVIQATFRMHGAYMRYQHLKRASVVIQVHTAAELQRQKHAAVILQAAVRGMKTRSHLKTMHSSATLIQSQFRAFIVRRRFIALRKAAIFVQRKFRATLYAKHKLHQFLQLRKAAITIQSSYRRLMVQKKLQEMHRAAALIQATFRMHRTYVAFHIWKCASIRIQQCYRTYRTIKLQKEKLIREEQHSAAVLIQSTYRMYRQRCFYQQRRWAAKVIQKTYRANKRRQDLLYVCKEETPLLQMHFQGLNTAKQGRQQHGAAMITQKHFRAFKARRLMEAERGFQAGCRKYKAKKYLSKVEAACRIQAWYRRWRAHKKYLTLLKAVNIIEGYLSAQLARRRFLKMRAAAIIIQRKWRATLSVRGARENLKRHRAACVIQAHFRGYQARQSFLQQRSAVLIIQRHVRAMVAAKQERIKYIKLKKSTVVVQALVRGWLVRKRVSEQKAKTRLFHFTAAAYCHMCALKIQRAYRLHVTLRNAKKHMDSVIFIQRWFRKRLQRKRFIEQYHKILSTRREAHACWLQQDRAASVIQKAVRRFLLCRRQEKITSCATRIQALWRGYSWRKKNDHTEIKAIRRSLRAVSTTVEEENKLYRRTERALHHLLTYKHLSAILDALKHLEVVTRLSPLCCENMAESGAVSTIFVVIRSCNRSVPCMEVVGYAVQVLLNVAKYDKTIAAVYEAENCVDTLLELLQVYREKPGDRVAEKSASIFTRTCCLLAVLLKTEQCAFDAQSRSKVTDRIYRLYKFTVPKHKVNTQGLFDKQKQNSCVGFPCIPERTMKTRLVSRLKPQWVLRRDNVEEITNSLQAIQLVMDTLGISY

ASPM

Abnormal spindle-like microcephaly-associated protein homolog

1527 amino acids

Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity).

184.736 kDa

single

LRGNQVHQGSKMLKSSFLVIQVMFRRWKRRKMQLQVKAAVTLQRAFREWHLRKRAKEEKSAIVIQSWYRMHKQLQKYAYVRACVVIIQKRFRCFQAQKLYKRRKESILTIQKYYRAYLKGKIERTNYLQKRAAAIQLQAAFRRLKAHRLRRQIRAACVIQSYWRMRQDRVRFLNHRKIIIKLQAHVRKHQQLQKYKKMKKAAVVIQTRFQAYIFARKVLASYQKTRSAVILLQSAYRGMQARKMYIQIPTSVIKIQPYYRAYVSKKEFLSLKNATIKLQSIVKMKQTRKQYLHLRATAVFIQQHYRSKKLAAQKREEYMQMRESCIKLQAFVRGYLVRKQMRLQRKAVISLQSYYRMRKARQCYLKMYKVVIIIQNYYHSYKAQVNQRKNFLQVKKAATCLQAAYRGYKVRQLIKQQSIAAVKIQSAFRGYSKRVRYQSVLQSIIKIQRWYRAYKTLSDIRTHFLKTKAAVISLQSAYRGWKVRKQIRREHQAAMKIQSAFRMAKAQKQFRLFKTAALVIQQHLRAWSTGRKQHMQYIELRHPVLMLQSMWKGKTLRRRLQRQHKCAVIIQSYYRMHVQQKKWKTMKKAALLIQKYYRAYSIGREQHHLYLETKAAVVTLQSAYRGMKVRKRIKDCKKAAVTIQSKYRAYKTKKKYAAYRSSAIIIQRWYRGIKITNHQYKEYHSLKKTVIKIQAVYRGIRIRRHIQHMHRAATFIKAMFKMHQSRIRYHTMRKAAIVIQVRYRAYYQGKMQRENYLKILRAVNVLQANFRGVRLRRTLRNLQIAATVIQSNYRRYREQTYFNKLKKITKTVQQRYRAVKERNILFQRYNKLRHSVIYIQAVFRGMKARRHLKTMHLAATLIQRRFRTLMMRRRFLSLKKTAIWIQRKYRAHLCTKHHLQFLLLQNAAIKIQSSYRRWMIRKRMREMHRAATFIQATFRMHRVHRRYQALKQASAMIQQQYQANRAAKLQRQHYLRQRHSAVILQAAFRGMKTRRHLKSMHSSAVRIQSRFRSLLVRRRFISLKKAAIFIQRKYRATICAKHKLHQFLKLRKAAITIQSSYRRLMVKKKLQEVHRAAVLIQATFRMHRTYLTFQTWKHASILIQQHYRTYRASKLQRENYTKQWRSAVIIQAAYRGMKARQLLREKHKAAVIIQSTYRMYRQYCLYQNLQWATKIIQEKYRANKKKHKALQHNELKKAETCVQASFQDMNIKKLIQEQHQTSIIIQKHCKAFKIKKHYLHLREPVVSIQRRYRKLTAVHTQAVICIQSYYRGFKVRRDIQNMHLAATRIQSFYRMHRAKVDYQTKKTAIVVIQNYYRLYVRVKTERRNFLAVQKSVRTIQAAFRGMKVRQKLKNVSQEKIAAIVNRSALYCYGSKAQCEAVGSEGVIIQEWYKASCFACSQEAEYRSQSRAAVTIQKAFRRMITRKLDTRKCAALRIQFFLQMAVYRRRRANFVQQKRAAVTLQHYFRMWQTRKQFLLYRKAAVVLQNHYRAFLSGKHQRQVYLQIRSSVIIIQARIKGFIQKRKFQ