Function
Required to prevent promoter DNA hypermethylation and transcriptional silencing of some transgenes (PubMed:24003136). Plays a similar role to that of the histone H3K9 demethylase JMJ25/IBM1 in preventing CHG methylation in the bodies of numerous genes. RNA-binding protein that ensures the proper expression of JMJ25/IBM1 full-length transcript by associating with an intronic heterochromatic repeat element of JMJ25/IBM1 (PubMed:24003136, PubMed:23934508, PubMed:24404182). May associate with intronic heterochromatin and bind gene transcripts to promote their 3' distal polyadenylation (PubMed:24003136). Contributes to a unique mechanism to deal with the collateral effect of silencing intronic repeat elements (PubMed:24003136, PubMed:23934508, PubMed:24404182).
Sequence
MEESVASEGLEFKWGKKKGVGGKKKDVQFYESFTYDGDEYRLYDCVLVGNASEPDSTEPFIGMIIKIWEHANKHIPKKVKLLWFFKPSEIAPYLEGVPNVLANEVFLASGEGLGLANTNQLEAIGGKCSVLCISKDKRNPQPSDEKFNSADFVFCRAFDVGSCKVVDTIDDKIAGVDVKFIFNRACSEKEATAVQNIEADVNGKSDSLKPNGPLARGASGSVRKIEDSAFESSDCKENSNGCKEEKEKGHYQLAIKKSTLAEERSNKDSGSRGNHYNGKDQESEVKKQLTKQKSMPGEERYSNSFEASGSRTIHSISKKAQENDVKKQLTKQKSMPAGERYSQESSGLDDRPLKKQKLDGSVTVRDGWDTTILQNITSDGKKDTGSFKRPRDKVTIEEVPPEKRSFVKNRDLVVSVSEGKTTKTVTEKGISKKPSFGRAEDKMSADDNERNYQVTEVCRRPDAGKSKWFRSLPWEESMREAEKKGTVVLLQNLDPTYTSDEVEDIVYSALNQQCEARMIERTSVTIPHIGEALVIFKTREVAERVIRRLDEGCLLLSSGRPLVASFAKITPPGKPSLFSGHIKLHKTQTRREMRDAVATSHSSQPNNLEFDMAMEWCLHQARHEQASESVSKRQLEEMKSLRINFKLKLP