Protein
Armadillo repeat-containing X-linked protein 1
Organism
Rattus norvegicus
Function
Regulates mitochondrial transport during axon regeneration. Increases the proportion of motile mitochondria by recruiting stationary mitochondria into the motile pool. Enhances mitochondria movement and neurite growth in both adult axons and embryonic neurons. Promotes neuronal survival and axon regeneration after nerve injury. May link mitochondria to the Trak1-kinesin motor complex via its interaction with MIRO1.
Similarity
Belongs to the eutherian X-chromosome-specific Armcx family.
Sequence
MGRTREAGCVAAGMVIGAGACYCVYRLTWGKDENEKLWDDEDEEEEEEEESCSGKPEIGGKTVKERKTHVGVGAGAKPQDDSKSKAEANVGPENGPDVKKEVYPESHSEGGLEAKAKALFKSLKEQASAKAGRGIRFPNISRIRTLTSSLPCPGGRGGGCHPGRTGSRARNRTSGKVKRKNRSKSNKAPATAWPVRRGKFSFPYKIDDILSAPDLQKVLNILERTNDPFTQEVALVTLGNNAAYSFNQNAIRELGGVPIIAKLIKTRDPIIREKTYNALNNLSVNSENQGKIKTYISQVCDDTMVCRLDSAVQMAGLRLLTNMTVTNHYQHLLSYSFPDFFALLFLGNHFTKIQTMKLIINFTENPAMTRELVSCKVPSELISLFNKEWDREILLNILTLFENINDNIKSEGLASSRKEFSRSSLFFLFKESGVCVKKIKALASHKDLVVKVKVLKVLTKL