ARID5B

AT-rich interactive domain-containing protein 5B

1188 amino acids

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.

Belongs to the ARID5B family.

132.375 kDa

MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGFHAGPVKTEALGRNGQKEALLKYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSDGKAVAKVKCEARSALTKPKNNHNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQDAAEVSSEQEKEQETLISQKSIPEPLPAADMKKKIEGYQEFSAKPLASRVDPEKDNETDQGSNSEKVAEEAGEKGPTPPLPSAPLAPEKDSALVPGASKQPLTSPSALVDSKQESKLCCFTESPESEPQEASFPSFPTTQPPLANQNETEDDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIARDDLCSSLSQTHHGQSTDHMAVSRPSVIQHVQSFRSKPSEERKTINDIFKHEKLSRSDPHRCSFSKHHLNPLADSYVLKQEIQEGKDKLLEKRALPHSHMPSFLADFYSSPHLHSLYRHTEHHLHNEQTSKYPSRDMYRESENSSFPSHRHQEKLHVNYLTSLHLQDKKSAAAEAPTDDQPTDLSLPKNPHKPTGKVLGLAHSTTGPQESKGISQFQVLGSQSRDCHPKACRVSPMTMSGPKKYPESLSRSGKPHHVRLENFRKMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPSKEVSGKEKASEQESEGSKAAHGGHSGGGSEGHKLPLSSPIFPGLYSGSLCNSGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPSSQLSSVHPSTKL

Arid5b

AT-rich interactive domain-containing protein 5B

1188 amino acids

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver (By similarity). Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation.

Belongs to the ARID5B family.

131.837 kDa

MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWAHSDFSKWRCGLRATPVKTEAFGRNGQKEALLRYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSRNPQILYCRDTFDHPTLIENESVCDEFAPNLKGRPRKKKTCPQRRDSFSGSKDPNNNCDGKVISKVKGEARSALTKPKNNHNNCKKTSNEEKPKLSIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENNTQENENKTKVSGNKRIKQEMAKNKKEKENTPKPQDTSEVSSEQRKEEETLNHKSAPEPLPAPEVKGKPEGHKDLGARAPVSRADPEKANETDQGSNSEKEAEEMGDKGLAPLLPSPPLPPEKDSAPTPGAGKQPLASPSTQMDSKQEAKPCCFTESPEKDLQGAPFSSFSATKPPLTSQNEAEEEQLPATANYIANCTVKVDQLGSDDIHTALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKLIAREDLCSGLSQGHHSQSSDHTAVSRPSVIQHVQSFKNKASEDRKSINDIFKHDKLSRSDAHRCGFSKHQLGSLADSYILKQETQEGKDKLLEKRAVSHAHVPSFLADFYSSPHLHSLYRHTEHHLHNEQSSKYAARDAYQESENGAFLSHKHPEKIHVNYLASLHLQDKKVAAAEASTDDQPTDLSLPKNPHKLTSKVLGLAHSTSGSQEIKGASQFQVVSNQSRDCHPKACRVSPMTMSGPKKYPESLARSGKPHQVRLENFRKMEGMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPAKEASGKEKASEQESEGNKGAYGGHSGAASEGHKLPLSTPIFPGLYSGSLCNSGLNSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAGINPQAAFPSSQLSSVHPSTKL

ARID5B

AT-rich interactive domain-containing protein 5B

1187 amino acids

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation (By similarity).

Belongs to the ARID5B family.

129.976 kDa

MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGLQAGAVKTTALGRNGQKEALLKYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPPSILTDQFALALGGIAVVSKNPQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSDGKAVAKVKCEARSALSKPKNNHNNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQESPEVSSEPEKEQETSNQKSITEPLPAAEGKRKMEGYQDFAARPVGSRADPEKDSDADRGAGGATAAEEAGEQGPVPPLPSAPAAPDRGPALGPGAGKQPLTSPSAPADSKQEPQPCCFAESPDSEPQEPPFPGFPAAQPPLASQSELEEDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGAGLSGSYPYGSPPPLISKKKLIPRDELCSGLPQAHPGQGSDHAAVSRPSVIQHVQSFRSKASEERKGLGDLFKHDKLGRSEPHRCSFSKHHLGPLADSYALKPDAPEGKDKLLEKRALPHAHVPSFLADFYSSPHLHSLYRHAEHHLHAEQTSKYACRDAYRESENSSFPAHKHQEKLHVNYLASLHLQDKKPAPAEAPADEQPTDLSLPKNLHKPTGKVLGLAHAAPGPQESKGAPQFPAGNGQSRDGHPKACRVSPMTLSAPKKYPEPLSRASRPHHVRLESFRKLEGMVHPVLHRKAGPQAVGAARPIKRGLEDLDLVIAGKKARAVSPLDPPKEACGKDKGAELEGEGGKAAAAHGGPAADGHKAALSSPIFPGLYSGSLCGSGLGSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPASQLSSVHPSTKL

ARID5B

AT-rich interactive domain-containing protein 5B

1185 amino acids

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes (By similarity).

Belongs to the ARID5B family.

132.723 kDa

MERSALQWVGAPCGSHGPYVFYRAFRFQRRGGGRARVLSLGDFFFVRCRAEEPACIAELQLLWEERTSRQLLSSAKLYFLPEDTPQGRTSDHGEDEVIAVSEKVTVKLEDLAKWAQSDFSKWKCGFRAEPVKPMDVGKNGQKEALMRYRQSTLNSGLNFKDILKEKADLGEDDEDSNLLILSYPQYCRYRSMLKRIQDKPSSILTDQFVLALGGIAVTSKNPQIFYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSLNGIKDSNNNSESKAVAKVKCEAKSALPKPKSNNSNCKKGSSEDKSKIAVGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPVKPRKQDNSSQEGEAKTKVSGTKRIKNENQKSKKEKDNAQKPQDASEVSSEQEKDQESADQKNFTEHPTAGETKQPNQGPPPLLPEAARPLPMEKIDVTENSSSSEKAKEEVPHLSSFPSLSMPPDEDTVLDATVTKRLHSSADTQEDTKPERRIHKAFTESLENEPPEMPFSTFPVQLPTQSDMEDDKLPEMADYIANCTVKVDQLGNEDIHNALKQTPKVLVVQNFDMFKEKELPGSMSDDSTFGYTPLLYSKGNPGIMSPLAKKKLLSQVSGAALSCSYPYGSPPPLISKKKLNSRDELSSSLSQGPHVPNSDPIAINRPSVIQHVQSFKSKEERKSINDVFKHDMLSKVDPQRCDFSQHCLSSLAESYVPKTDIQDCKDKMTEKRALQHSRVPTFLADFYSSPHLHNLFRHTEHHLNNEQTSKYLPRDMFRESENISTFTQHKHQEKLNLNYHPSLHQQEKKATVEASSDDQPTDLSLPKSIHKQTAKAPGPGLSHSSMAQQEGKGVSLFQAASSQAVSLDCNPKACRVSPMAMTAPKKHSELLHRSGKQQAQRLENLRKMEGMVHPIISRRMSPQNIGAARPLKRGLEELDKVISEKKVRAVSPLHLPKETSVKEKVPDAEGEGSKSLHGLHSGSVLESHKFPLSAPIFPGLYPGTLCTGLNNRLPPGYSHPLQYLKNQTVLSPLMQPLALHSLMVQRQFLTSPANSQQLYRHLATATPVGSSYGDLLHNSIYPLAAINPQAAFPPSQLSSVHPSTKL

ARID5B

AT-rich interactive domain-containing protein 5B

1173 amino acids

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-340, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation (By similarity).

Belongs to the ARID5B family.

130.464 kDa

MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGLQAGSVKTESLGRNGQKEALLKYRQSTLNSGLNFKDVLKEKADLDCLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPSSILTDQFALALGGIAVVSKNPQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGGKDPNNNSDGKSVAKVKCEARSALNKPKNNHNNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENNSQENENKTKVSGAKRIKHEISKSKKEKENAPKPQDASEVSSEQEKEQETVNQKSITEPLPIADTKKKLEGYQDFAARPLVSQADPEKDSETDQGANSEKVAEEAGEKGPAPPLASAPLAPTPGTGKQSLTSPSALVDSKEPKPCCFTESPENELQEASFPGFSTTQPPLANQSEVEDDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGASLSSSYPYGSPPPLISKKKVIAREDRCSSLSQAHHGQSTDHMAVNRPSVIQHVQSFRSKPSEERKISDIFKHDKLSRSEPRFSFSKHHLSPSKKSRGRRTVEKRALPHSHMPSFLADFYSSPHLHSLYRHTEHHLHNEQTSKYPCRDMYRETENSSFPSHKHQEKLHVNYLASLHLQDKKSAAVEAPTDDQPTDLSLPKNPHKPTGKALGLAHSAPGPQESKGTSQFQVINSQSRDCHPKACRVSPMTMSAPKKYPEALSRSGKPHPVRLENFRKMDSMVHPILHRKMSPQNIGAARPIKRSLEDLDLVIAGKKARAVSPLDPAKEVSGKEKASEQESEGSKAAHSGHSGGTSEGHKLPLSSPIFPGLYSGSLCSSGLNSRLPAGYSHSLQYLKNQAVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPSSQLSSVHPSTKL

arid5b

AT-rich interactive domain-containing protein 5B

1044 amino acids

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes (By similarity).

Belongs to the ARID5B family.

115.806 kDa

MVSDLRSWKKGLQAVPLKPGVLKELGKNGQREALHKYRESTLNSGLNFKDVLKEKAELGEDADDKKVLVLSYPQYCRYRSIIARLRERPSSLLTDHVVLALGGIASLTNSTQILYCRDTFEHPTLVENESVCDEFAPNLKGRPRKKKLSISQRRDSQSGGARESNGVEGKTLVKMRADSKSGVSKPRNPSTGSCKRVQSENKPKGDGGDECRTDEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYEVITARRQWKNVYDELGGNPGSTSAATCTRRHYERLILPYERFTKGEEDKPLPPAKPRKQEGSVQESIIKAKMMPIKRPKDEQKTPRGDKDASAKVLELGMEDMEELQEKQNSQQLQAPTQTDRDPNSPLTEDDEGVLVIKDEDQPVLHNAYEHANGGLLPSLPQDGAQLKSEDCDAFPVAAVPLHHGHPLPNSHTSDQWKHGILEYKVPPSALANVEQSRPKEGQNQVVMVLPTLQQKPVTSPEIPPERVEPLKKEESCFNFNPLLYPRGNPGIMSPLAKKKMLSQVSGTGLLNNYPYGPPPPLVSRRLSSSGTEVSSAGQSSSQVSSSVETSIVIKRPSVIQHAQSFKSRGSEDRRSSTEGSQKDGCSEGEPVHHSQTLIREPYLKRVDPHSSMEKSAEMPRPGQAPSFLSEFYSSPHLHNLCRQTEHHLSKEQISKYLSRDVYTRDSETAQGFPPSQHPDNVGLNFSARLSQKEKGPPPERVTEEQPTDLSLPKSSPLKLPLSTSTLGGIPHAAIQQDIKNSPHFQAGNSQSSSVDYHPRACRVPPMTVSASKKVTESHSKVLEKTPNSRGEESMGFKIDEMSRPILSTKSSPQNICTARPLKRNIEDLENGPTEKKIRAVTPLHCSTQRDLPGKPRTPEADSESVKPAEPAVHINSYTSEGHKIPLHSHLFQGLYPGTFVSQVQDMCESLGSHVTPSYSHPLQYLKNQAVLSPLMPPFAIHSLMMQRQFLAANPAHMYRHQVGTSYGDILHPGLYPMSALHPQPAFSPPQLSSVHPSTKLS