Arhgap32

Rho GTPase-activating protein 32

2089 amino acids

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.

Belongs to the PX domain-containing GAP family.

229.719 kDa

METESETSSLGDDSVFWLDCEGVTQLTDGDEEEREESFRKMKSSIHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTLKSCGSTASTKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLTELPRSDVLKDSPESVTQMLTAYLSRLSTIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGKISAVMQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVSSPIVTENKYIEVGEGPAALQGKFHTVIEFPLERKRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDSKLFRPRRPRSSSDALSASFNGDVLGNRCNSYDNLPHDNESEEEVGLLHIPALVSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSLGYTRDKLSPSKKDAEAGGSQSQTPGSTASSEPVSPVQEKLSPFFTLDLSPTDDKSSKPSSFTEKVVYAFSPKIGRKLSKSPSMNISEPISVTLPPRVSEVIGTVSNTVAQNASPTSWDKSVEERDVINRSPTQLQLGKMKAGEREAQETCEPEAQPLEQGAAEEVELPGTEERPVLSSQSKAVPSGQSQTGAVTHDPPQDPVPVSSVSLIPPPPPPKNVARMLALALAESAQQASSQTLKRPGASQAGCTSYGDTAVVPSEEKLPSSYSSLTLDKTCFQTDRPAEQFHPQINGLGNCNQPLPEAAAMGGPTQSNTTDSGEQLHQVDLIGNSLHRNHISGDPEKARSTSAPLTDSEKSDDHGSFPEDHAGKSSVSTVSFLEQDQSPLHFSCGDQPLSYLGTSVDKPHHSSELTDKSPMPSTLPRDKAHHPLSGSPEENSSTATMAYMMATPARAEPSNSEASRVLAEQPSAADFVAATLQRTHRTNRPLPPPPSQRPAEQPPVVGQVQEAPSIGLNNSHKVQGTAPAPERPPESRAMGDPAPIFLSDGTAAAQCPMGASAPQPGLPEKVRESSRAPPLHLRAESFPGHSCGFAAPVPPTRTMESKMAAALHSSAADATSSSNYHSFVPSSASVDDVMPVPLPVSQPKHASQKIAYSSFARPDVTAEPFGPENCLHFNMTPNCQFRPQSVPPHHNKLEPHQVYGARSEPPASMGPRYNTYVAPGRNMSGHHSKPCSRVEYVSSLGSSVRNPCCPEDILPYPTIRRVQSLHAPPPSMIRSVPISRTEVPPDDEPAYCPRPVYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPEGALCDVDAYGTVQLRPLHRLSSRDFAFYNPRLQGKNVYNYAGLPPRPRANATGYFSGNDHNVVTMPPTADGKHTYTSWDLEDMEKYRMQSIRRESRARQKVKGPIMSQYDNMTPAVQEDLGGIYVIHLRSKSDPGKTGLLSVAEGKEGRHPAKAVSPEGDERFYRKHPESEFDRAHHHGGYGSTQAEKPSLPQKQSSLRNRKLHDMGCSLPEHRAHQEASHRQLCESKNGPPYPQGAGQLDYGSKGMPDTSEPSNYHNSGKYMTSGQGSLTLNHKEVRLPKDLDRPRARQPPGPEKHSRDCYKEEEHFSQSMVPPPKPERSHSLKLHHTQNLERDPSVLYQYQTHSKRQSSMTVVSQYDNLEDYHSLPQHQRGGFGGAGMGAYVPSGFVHPQSRTYATALGQGAFLPTELSLPHPDTQIHAE

ARHGAP32

Rho GTPase-activating protein 32

2087 amino acids

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).

Belongs to the PX domain-containing GAP family.

230.529 kDa

METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQGKSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDTLKDSPESVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINTPAVGAAHVIKRYTARAPDELTLEVGDIVSVIDMPPKVLSTWWRGKHGFQVGLFPGHCVELINQKVPQSVTNSVPKPVSKKHGKLITFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGIVDGIYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLFSGRISMAMQEGAASLSRPKSLLVSSPSTKLLTLEEAQARTQAQVNSPIVTENKYIEVGEGPAALQGKFHTIIEFPLERKRPQNKMKKSPVGSWRSFFNLGKSSSVSKRKLQRNESEPSEMKAMALKGGRAEGTLRSAKSEESLTSLHAVDGDSKLFRPRRPRSSSDALSASFNGEMLGNRCNSYDNLPHDNESEEEGGLLHIPALMSPHSAEDVDLSPPDIGVASLDFDPMSFQCSPPKAESECLESGASFLDSPGYSKDKPSANKKDAETGSSQCQTPGSTASSEPVSPLQEKLSPFFTLDLSPTEDKSSKPSSFTEKVVYAFSPKIGRKLSKSPSMSISEPISVTLPPRVSEVIGTVSNTTAQNASSSTWDKCVEERDATNRSPTQIVKMKTNETVAQEAYESEVQPLDQVAAEEVELPGKEDQSVSSSQSKAVASGQTQTGAVTHDPPQDSVPVSSVSLIPPPPPPKNVARMLALALAESAQQASTQSLKRPGTSQAGYTNYGDIAVATTEDNLSSSYSAVALDKAYFQTDRPAEQFHLQNNAPGNCDHPLPETTATGDPTHSNTTESGEQHHQVDLTGNQPHQAYLSGDPEKARITSVPLDSEKSDDHVSFPEDQSGKNSMPTVSFLDQDQSPPRFYSGDQPPSYLGASVDKLHHPLEFADKSPTPPNLPSDKIYPPSGSPEENTSTATMTYMTTTPATAQMSTKEASWDVAEQPTTADFAAATLQRTHRTNRPLPPPPSQRSAEQPPVVGQVQAATNIGLNNSHKVQGVVPVPERPPEPRAMDDPASAFISDSGAAAAQCPMATAVQPGLPEKVRDGARVPLLHLRAESVPAHPCGFPAPLPPTRMMESKMIAAIHSSSADATSSSNYHSFVTASSTSVDDALPLPLPVPQPKHASQKTVYSSFARPDVTTEPFGPDNCLHFNMTPNCQYRPQSVPPHHNKLEQHQVYGARSEPPASMGLRYNTYVAPGRNASGHHSKPCSRVEYVSSLSSSVRNTCYPEDIPPYPTIRRVQSLHAPPSSMIRSVPISRTEVPPDDEPAYCPRPLYQYKPYQSSQARSDYHVTQLQPYFENGRVHYRYSPYSSSSSSYYSPDGALCDVDAYGTVQLRPLHRLPNRDFAFYNPRLQGKSLYSYAGLAPRPRANVTGYFSPNDHNVVSMPPAADVKHTYTSWDLEDMEKYRMQSIRRESRARQKVKGPVMSQYDNMTPAVQDDLGGIYVIHLRSKSDPGKTGLLSVAEGKESRHAAKAISPEGEDRFYRRHPEAEMDRAHHHGGHGSTQPEKPSLPQKQSSLRSRKLPDMGCSLPEHRAHQEASHRQFCESKNGPPYPQGAGQLDYGSKGIPDTSEPVSYHNSGVKYAASGQESLRLNHKEVRLSKEMERPWVRQPSAPEKHSRDCYKEEEHLTQSIVPPPKPERSHSLKLHHTQNVERDPSVLYQYQPHGKRQSSVTVVSQYDNLEDYHSLPQHQRGVFGGGGMGTYVPPGFPHPQSRTYATALGQGAFLPAELSLQHPETQIHAE

arhgap32

Rho GTPase-activating protein 32

1940 amino acids

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases.

Belongs to the PX domain-containing GAP family.

216.024 kDa

MEGGTDAAAFAAFPSIHAVPSTSGRMVTGSKLDELERIMKSSLHLEEDDFVPELPRSIHPRERPDWEETISAMARGADITVPGEIQIPAELPLRSCGSTASMKVKNVKKLSFTKGHFPKLAECAHFHYENVDFGSIQLTLTEDQNEVNRNGCESKELVFLVQIACQGRSWIVKRSYEDFRVLDKHLHLCIYDRRFSQLSELPRSDSVKDNPELVTQMLMAYLSRLSAIAGNKINCGPALTWMEIDNKGNHLLVHEESSINVPAIAAAHVIKRYNAQAPDELSFEVGDIVSVIDMPPKELTTWWRGKHGFQVGFFPSECVELINDKVPQSMTNSVPKPVSRKHGKLITFLRTFMKSRPSKQKLKQRGILRERVFGCDLGEHLLNSGQDVPQVLRSCTEFIEKHGVVDGIYRLSGIASNIQKLRHEFDSEQIPDLTKDVYIQDIHCVGSLCKLYFRELPNPLLTYQLYEKFSDAVSAASDEERLVKIHDVIQQLPPPHYRTLEFLMRHLSRLATYCSITNMHTKNLAIVWAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVEVLFSAKLSSVIREGAGHTSLSRPKSLLVSSPSTKLLSLEEAQARTQAQINSPVVGDSRYIEVGEGPAALQGRFHTVIDFPSERKRPPSKMKKSPVGSWRSFFNIGKSSSSSSMSKRKLQRNPSEPLEMKSMAFAGGRDSSAMRSAKSEESLSSLHAADGESKLFRPRRPRSSSDALSASYNGDLLDSCNRCNSYDNLPRDHDSDGDEGLIHVPAMLSGRSPEDEDLSPPDIGMATLDFDPMSFQCSPHQLDSEGPDNFFQLDIFASNGKDKLQSGTQNPGSVTGCEPLSPFQDKVISPFLSPDRSPSTDKVSKTASFAEKFVQALSPKMGRKAVRSPPLTISDPVSISLPSRVSEMIGSMPGNSAASQSIIWNRESSTNSRESETYYGCKLVDANLSSSSATADPWSTVTPVITCNQDGREDKAGIFTHGFPQPLESSDLEYIENYNLELGTTNVAAAYQNDDTELSRANQNKAHPPNSPQGASASESPQELSHVSSVSIIPPPPPPKNPARMLALALAESAQQASANKKPSFMQFMDLPPPPSVPEDKPLLEFSPKMSPEPLRSGPATPAASPPVISRKTSPATPPSTTSSFSVTTIHHSPVKNYNPLAGQMPTAVTPGLSPSSNQVFASVPDMLHSETIKMNSIIPSEAFTTGIPVTPPTEKTKESSRAPHLHQRSESFPSHPAYSTAKPTPPVRTMDSRLATAMHSNFNDSITANNYHSFLNTMMLPSSLEDALPRHNYSPHLKTGNIDEEGVNYRQTYLSHNKQDDPADLGDLYRQPYISPGKSENAEIGNAYRHPYPSNTESESLKEPLEPFLHHKPAVAPKTYRAETLLPHIPPQVYGSRCDTPSSAFYGTYINQAKHPRSRNKPDYMPSMSPGVRSYTEDTSSYPTIRRVQSLHVPMQTLPPPIRTVPISRTEVPPDDDPAYCPRPLYQYKQCPPFNSQSDYHVTQLQPYFENGRVHYRYSPYSGGPTYFSSDSNFYDMDPYGTLRLRQLPLYPSRDFASYTTRLQPKATYRSQGLPPYPRGTLREHNFISRDVPPALPPEHPRPLHISWDMEDMDRYRLQSLRRENKARQRAKGPVMSQYDNVTPSLVEDVAGLDVIHLRSRSDPGKTPGLLSVAETKDVRYPGRTEGDERTTYPPPVFGNGHQDKPSLPQKQSGSSRSRMQHDISTEQHSQDTLHRQPSEGRNGPPIPPVDYNAKGMPNPPDPTSYHSSANKYNLTQQEPMRLNHKELRLTEDIERSHTRPADNQHRDCYREEQAQFASVVPPPKPERSHSLRAHNPAVLERDPSIFYPYQTLHAKRQSTINTVSQYDNLSDYHSIPHHRTTNQSTPNAFPLPHGRTYSTALGQGAFLAAELALQRPETKIHVE