arhgap29

Rho GTPase-activating protein 29

1337 amino acids

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42 (By similarity).

147.666 kDa

MFRQGSNSGNKRMTSGARLSQPIIPLSLPTASSKTLEMGRSSKTNPLNAMGLDHNIATSGGDPEYIMQLVNDVRKFSDVLLSLKEAFHSKESQECSQHVVNERLGELVHVLKAVIGKHQALNSSEILGAAGTVIAKVKGVNFKEVNNENKSTIFGEIHTSIDTLAFTFGNVVSDFLMGDVDGGSRLGYPQARRSRSFENLSEDSRGCSQNDLADHSLSPELSTVEQVDLLLLKNDSGVESALLYAKAWSKYTKDVLAWVEKRLSLDMECAKSFAKMAESAKAVASQQDFMPFRDIYVSAFKNEIEYNHVLLQTAAALQTNKFTQPLLARKNDLDKQRKEIKEQWQRELKKMNESESALKKARLLKMQKREEYEKARSSTSRTEEEQPAAGGRTLEKKRRVEEEALQKAEEAQEQYKACVADLEAKKVSLSNAKSEILAQIRKLVFQCDLTLKAVTVNWFQMQQAQTMPLSVNYQALSEQAKKYEPGQRYSEFVRSLPKERVWLESLSQDITASSKTGMSLHKRSQNSTRSSHGNLSQGSATSMDNHSADEVEGNMQPCKAKIAERRSNSSIDMQVPRTQGSQRAWSSGSAGGGGMCSDSESAGGSSESRSMDSPTASPGDFKRRLPRTPSTGTMSSADDLDEREPPSPSDTGLSEMVMETASSPGPFRNAQMSKAAHTHKLRKLRAPSKCRECDSLVVFHGAECEECSLACHKKCLETLAIQCGHKKLQGRLHLFGIDFAQVVKNSPDGIPFIIKKCTSEIESRALTIKGIYRVNGAKSRVEKLCQAFENGKDLVELSDLHPHDISNVLKLYLRQLPEPLILYRYYNDVIGLAKETQNMDKTDSAKEKSAGEQLGLSTELKRVLFKVRDLLRQLPAPHYKTLQFLITHLHRVSEQAEENKMTASNLGIIFGPTLIKPRHLEAEVSLSSLVDYPHQARMVELLIKHHQMIFDVPLSPMSPTSPTVSQASFGSSIQDKESKLSRHSRSLMDIKESAKLYKRHSSVIIPAQLMEEGKEMKTGDHRVQTSGEGSDVNGVGLTSVDSTSVFNRPGASSRMVQLRPQRAKPVSRPISMPIDRLLNERNSRNTVEHDHSPAAIEETTEPEKPTTPRHTNFYRNPFIDTQTLRRTWDRQYRHYDVTPRTAMIVANLPPSGVQKQPEISMASQSSTSRKDGTSQSGVAPISFRAARTLKPSSPGTFYRPPSGGQLKPSDLLAKSVSRAPTTTTGAIYTTAITVLTTASTSSVMTISTAVTTPPTTPTTSVTVALTSKPTFTTVSRSVSGGAGEGLSESDLLSPVTLSPPQSPGSSTEELSPTDAKPLYQRRSRRMQELEHREAHFV

ARHGAP29

Rho GTPase-activating protein 29

1269 amino acids

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity).

142.971 kDa

MIAYKQKKTKKKRVLSTGQLSTDVTTSEMGLKSINSNAILDPDYIKELVNDIRKFSHMLLYLKEAILSECFKEVIHIRLDELLRVLKSVMNKHQNLNSVDLQNAAEMLIAKVKAVNFTEVNEENKNDLFREVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSQESKSFESVSVESVDSSNEKGSFSPIELDSMLLKNTNSVELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNIVKLAEATRTNIGLQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLETETALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSSGLVKNLNRQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILTQLRKLVFQCDLTLKAVTVNLFQMQQLQAASLSSNLQSLCDSAKLYDPGQEYSEFVRATNSAEEEKVDGNVNKQLSSPPISGYGPSDSLEDVVRLPDSSNKMEEDRCSNSADITGPSFLRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSEAGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFHGVECEECLLVCHRKCLENLVIICGHQKLMGKIHLFGAEFTQVAKKEPDGIPFVLKMCASEIENRALSLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAVEIQHVNEEQEMKKDNPEDKKWPSSSIEISRILLKSKDLLRQLPASNFNSLHYLIVHLKRVVDHSEENKMNSRNLGVIFGPSLLRPRPTTAPITISSLADYSNQARLVEFLITYSQKIFDGSLQPQDSAVGSAGGIAPQVDPGYLPKSLLSPEERDPERSMKSLFFSSKEDIQTTDSECKSFESTPSFEESERKQNALEKCDAYLIDNKGRLLVDQELESASRKTEDACKTSKLPTLKSDREINGVERHLPRTRIRPVSLPIDRLLLLASSPTERNGRNMGNVNSDKLCKNPVFEGVNRKDSPTVVCSKFDGFDQQTLQKTREKQYEQNDHTAKTGMIVPSAFQERGVALNIRSSGDHPVSITQPSKPYTEPVRSTRQVSERRSSDSCPPASVRTPRTLQPQHWTTFYKPPAPAASGRGDEEKPVTPSVAVPPGTTHAPQEHVLKSVPGSENASAGPVHPVSRPEEKAEERDQPDVPTACQRPRLKRMQQFEDLEDEIPQFV

Arhgap29

Rho GTPase-activating protein 29

1266 amino acids

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.

142.341 kDa

MIAHKQKKAKKKRVWASGQPSAAITTSEMGLKSVSSSSSFDPEYIKELVNDVRKFSHMLLYLKEAILSDCFKEVIHIRLDELLRVLKSILSKHQNLSSVDLQSAAEVLTAKVKAVNFTEVNEENKNDIFREVFSSIETLAFTFGNILTNFLMGDVGSDSILRLPISRESKSFENISVDSVDLPHEKGNFSPIELDNLLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNIVKLAEATRSSIGIQEFMPLQSLFTNALLSDIHSSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKDLWKQQQNKLLETETALKKAKLLCMQRQDEYEKAKSSMFRAEEEQLSSSVGLAKNLNKQLEKRRRLEEEALQKVEEANEHYKVCVTNVEERRNDLENTKREILTQLRTLVFQCDLTLKAVTVNLFHMQQLQAASLANSLQSLCDSAKLYDPGQEYSEFVKATSSSELEEKVDGNVNKQMTNSPQTSGYEPADSLEDVARLPDSCHKLEEDRCSNSADMTGPSFVRSWKFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSEAGPNSLGAFKKTLMSKAALTHKFRKLRSPTKCRDCDGIVMFPGVECEECLLVCHRKCLENLVIICGHQKLQGKMHIFGAEFIQVAKKEPDGIPFVLKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQEAKKDSPEDKKHPHVSIEVNRILLKSKDLLRQLPASHFNSLHYLIAHLRRVVDHAEENKMNSKNLGVIFGPTLIRPRPTTAPVTISSLAEYSNQARLVEFLITYSQKIFDGSLQPQAVVISNTGAVAPQVDQGYLPKPLLSPDERDTDHSMKPLFFSSKEDIRSSDCESKSFELTTSFEESERRQNALGKCDAPLLDNKVHLLFDQEHESASQKMEDVCKSPKLLLLKSNRAANSVQRHTPRTKMRPVSLPVDRLLLLASSPTERSSRDVGNVDSDKFGKNPAFEGLHRKDNSNTTRSKVNGFDQQNVQKSWDTQYVRNNFTAKTTMIVPSAYPEKGLTVNTGNNRDHPGSKAHAEPARAAGDVSERRSSDSCPATAVRAPRTLQPQHWTTFYKPPNPTFSVRGTEEKTALPSIAVPPVLVHAPQIHVTKSDPDSEATLACPVQTSGQPKESSEEPALPEGTPTCQRPRLKRMQQFEDLEDEIPQFV

Arhgap29

Rho GTPase-activating protein 29

1266 amino acids

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity).

141.943 kDa

MIAHKQKKAKKKRVWASGQLSAAITTSEMGLKSVSSNSIFDPEYIKELVNDIRKFSHVLLYLKEAILSDCFKEVIHIRLDELLHMSKHQNLNSVDLQNAAETLASKVKAVNFTEVNDENKNDLFREVFSSIETLAFTFGNILTNFLMGDVGNDSILRLPISRESKSFENISMDSVDLPHEKGNFSPIELDNLLLKNSDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNIVKLAEATRSSIGIQEFMPLQSLFTNALLNDIHSSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQQQNKLLETETALKKAKLLCMQRQDEYEKAKSSMFRAEEEQLSSSVGLGKNLNKLLEKRRRLEEEALQKVEEANEHYKVCVTNVEERRNDLENTKREILTQLRTLVFQCDLTLKAVTVNLFHMQQLQAASLANSLQSLCDSAKLYDPGQEYSEFVKATSSSELEEKVDGNVNKQIASSPQTSGYEPADSLEDVARLPDSCHKLEEDRCSNSADMTGPSFIRSWKFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSEAGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVMFPGVECEECLLVCHRKCLENLVIVCGHQKLQGKMHIFGAEFIQVAKKEPDGIPFVLKICASEIESRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQEAKKDSPEDKKHPHVSIEINRILLRSKDLLRQLPASNFNSLHYLIVHLKRVVDHAEENKMNSKNLGVIFGPTLIRPRPTTAPVTISSLAEYSSQARVVEFLITYAQKIFDGSLQPQAGVIANTGAIAPQVDHGCHPKPLLSPDERDSDHSLKQLFFSSKEDIRTMDCESKTFELTTSFEESERKQNALGKCDAPILDNKVHLLFDQELESASHKTEDTCKSPKLLLLRSDRVANSVQRPTPRTRLRPVSLPVDRLLLLAGSPTERSSRNTGNTDSDKFGKNAAFEGLHRKDNSNTTCSKVNGFDQQNVQKSWDKQNERNSFTAKTTVIIPSAYAEKGLAVSTGNNRGHSSGAAQPSKAHADPARSARDTSEHSSSDSCPVAAVRAPRTLQPQHWTTFYKPPNPTFNVRGTEEKTAFPSAAVPPVLVHAPQSHVAKSDPDLEATLACPVQTSGQPKESSEEPGLPEGTPTCQRPRLKRMQQFEDLEDEIPQFV

ARHGAP29

Rho GTPase-activating protein 29

1261 amino acids

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.

142.064 kDa

MIAHKQKKTKKKRAWASGQLSTDITTSEMGLKSLSSNSIFDPDYIKELVNDIRKFSHMLLYLKEAIFSDCFKEVIHIRLEELLRVLKSIMNKHQNLNSVDLQNAAEMLTAKVKAVNFTEVNEENKNDLFQEVFSSIETLAFTFGNILTNFLMGDVGNDSLLRLPVSRETKSFENVSVESVDSSSEKGNFSPLELDNVLLKNTDSIELALSYAKTWSKYTKNIVSWVEKKLNLELESTRNMVKLAEATRTNIGIQEFMPLQSLFTNALLNDIESSHLLQQTIAALQANKFVQPLLGRKNEMEKQRKEIKELWKQEQNKMLEAENALKKAKLLCMQRQDEYEKAKSSMFRAEEEHLSSSGGLAKNLNKQLEKKRRLEEEALQKVEEANELYKVCVTNVEERRNDLENTKREILAQLRTLVFQCDLTLKAVTVNLFHMQHLQAASLADSLQSLCDSAKLYDPGQEYSEFVKATNSTEEEKVDGNVNKHLNSSQPSGFGPANSLEDVVRLPDSSNKIEEDRCSNSADITGPSFIRSWTFGMFSDSESTGGSSESRSLDSESISPGDFHRKLPRTPSSGTMSSADDLDEREPPSPSETGPNSLGTFKKTLMSKAALTHKFRKLRSPTKCRDCEGIVVFQGVECEECLLVCHRKCLENLVIICGHQKLPGKIHLFGAEFTQVAKKEPDGIPFILKICASEIENRALCLQGIYRVCGNKIKTEKLCQALENGMHLVDISEFSSHDICDVLKLYLRQLPEPFILFRLYKEFIDLAKEIQHVNEEQETKKNSLEDKKWPNMCIEINRILLKSKDLLRQLPASNFNSLHFLIVHLKRVVDHAEENKMNSKNLGVIFGPSLIRPRPTTAPITISSLAEYSNQARLVEFLITYSQKIFDGSLQPQDVMCSIGVVDQGCFPKPLLSPEERDIERSMKSLFFSSKEDIHTSESESKIFERATSFEESERKQNALGKCDACLSDKAQLLLDQEAESASQKIEDGKTPKPLSLKSDRSTNNVERHTPRTKIRPVSLPVDRLLLASPPNERNGRNMGNVNLDKFCKNPAFEGVNRKDAATTVCSKFNGFDQQTLQKIQDKQYEQNSLTAKTTMIMPSALQEKGVTTSLQISGDHSINATQPSKPYAEPVRSVREASERRSSDSYPLAPVRAPRTLQPQHWTTFYKPHAPIISIRGNEEKPASPSAAVPPGTDHDPHGLVVKSMPDPDKASACPGQATGQPKEDSEELGLPDVNPMCQRPRLKRMQQFEDLEGEIPQFV