ARHGAP21

Rho GTPase-activating protein 21

1958 amino acids

Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions.

217.462 kDa

MMATRRTGLSEGDGDKLKACEVSKNKDGKEQSETVSLSEDETFSWPGPKTVTLKRTSQGFGFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQDAYLKGNEAYSGNARNIPEPPPICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQPGRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLSNRNNHTGPSHRTEEVRYGVSEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGHSDGISSSRSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQSTTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGALTSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNGEKKQTYKWSGFTEQDDRRGICERPRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQSNRNFQTTCGMSLPRGISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSLLNQQTWVRTDSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQEAETEQSDTLDNKEAVILREKPPSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARREVHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHDIAHIPASAVISASTSQVPSIATVPPCLTTSAPLIRRQLSHDHESVGPPSLDAQPNSKTERSKSYDEGLDDYREDAKLSFKHVSSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEGWLHFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEEEQPISVNACLIDISYSETKRKNVFRLTTSDCECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRKGIPSIMRKTFEKKPTATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTTVQEESTVDSQPVPNIDHLLTNIGRTGVSPGDVSDSATSDSTKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDNVFFKKENVEQCHNDTKEESKKESETLGRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPSEEPSPPHNSKHNKSPTLSCRFAILKESPRSLLAQKSSHLEETGSDSGTLLSTSSQASLARFSMKKSTSPETKHSEFLANVSTITSDYSTTSSATYLTSLDSSRLSPEVQSVAESKGDEADDERSELISEGRPVETDSESEFPVFPTALTSERLFRGKLQEVTKSSRRNSEGSELSCTEGSLTSSLDSRRQLFSSHKLIECDTLSRKKSARFKSDSGSLGDAKNEKEAPSLTKVFDVMKKGKSTGSLLTPTRGESEKQEPTWKTKIADRLKLRPRAPADDMFGVGNHKVNAETAKRKSIRRRHTLGGHRDATEISVLNFWKVHEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRTSTSDLSRGEIGDPQTENPSTREIATTDTPLSLHCNTGSSSSTLASTNRPLLSIPPQSPDQINGESFQNVSKNASSAANAQPHKLSETPGSKAEFHPCL

Arhgap21

Rho GTPase-activating protein 21

1944 amino acids

Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity).

215.743 kDa

MATHWTGLPEEDGDKLKACGAASACEVSKNKDGKDQGEPVSPSEDEPFSWPGPKTVMLKRTSQGFGFTLRHFIVYPPESAIQFSYKDEENGNRGGKQRNRLEPMDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDTTLELSVMPKDEDILQVAYSQDAYLKGNEAYSGNARNIPEPPPVCYPWLPSTPSATAQPVETCPPDSLPNKQQTSAPVLTQPGRAYRMEIQVPPSPTDVAKSNTAVCVCNESVRTVIVPSEKVVDLLANRNNPSGPSHRTEEVRYGVNEQASTKAASRTTSPASVPTAHLIHQTTGSRSLEPSGILLKSGNYSGHSEGISSSRSQAVDSPPVSVNHYSANSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQSAADYNQVVPTRTTLQVRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGALTSPPVSFNNHRTRSWDYIEGQTEATATVNSESQIPDSNGERKQTYKWSGFTEQDDRRGIHERPRQQEMHKPFRGSNLTVAPVVNSDNRRLVGRGVGPVSQFKKIPPDLRPPHSNRNFPTTTGVSLQRGIAQDRSPLVKVRSNSLKVPPPPVSKPSFSQHSLASMKDQRPVNHLHQHSVLSQQTQFRSESTFEHQLETEVSSCLPGTSAKTSPQLSENLGTSDLELPAIPRNGDINLQEAEIQQPDVLDNKESVILREKPQSGRQTPQPLRHQSYILAVNDQETGSDTTCWLPNDARREVHIKRMEERKASSTSPPGDSLASIPFIDEPTSPSIDHEIAHIPASAVISASTAHVPSIATVPPSLTTSAPLIRRQLSHDQESVGPPSLDGQHSSKTERSKSYDEGLDDYREDAKLSFKHVSSLKGIKITDSQKSSEDSGSRKGSSSEVFSDAAREGWLQFRPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDRREQTTPSEEEQPISVNACLIDISYSETKRRNVFRLTTSDCECLFQAEDRDDMLSWIKTIQESSNLNEEDTGVTNRDLISRRIKEYNSLLSKTEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTSPPKDKGTWRRGIPSIVRKTFEKKPAATGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLRTLKRLIHDLPEHHFETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEPLTAVQEENTVDSQPVPNIDHLLTNIGRTGVLPGDVSDSATSDSAKSKGSWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQPSSSEDELDSVFFKKENTEQSHSEIKEESKRESETSGSKQRVVVAKESNTKKDSGTTKEEKKIPWEEPPPPHSSKRNRSPTLSCRLAMLKEGPRSLLTQKPHCEETGSDSGTLLSTSSQASLLRSSTKKSTSPETKHSEFLSIAGTTTSDYSTTSSTTYLTSLDSSRLSPEVQSVAESKGDEADDERSELVSEGRPVETDSESEFPVFPTTLTSDRLFRGKFQEVARVSRRNSEGSEASCTEGSLTPSLDSRRQQFSSHRLIECDTLSRKKSARFKSDSGSPGDTRTEKETPALAKMFDVMKKGKSTGSLLTPSRSESEKQEATWKTKIADRLKLRPRAPADDMFGVGNQKPTAETAKRKNIKRRHTLGGHRDATEISVLSFWKAHEQSADKESELSAVNRLKPKCSAQDLSISDWLARERVRTSASDLSRGEGLEPQAESPSVLGTPISTHSPPSQQPEARVAATSTLASTSQSPLFTPPQSPDQINRESFQNMSQNASSTANIHPHKQSESPDTKAETPP

arhgap21

Rho GTPase-activating protein 21

1935 amino acids

GTPase-activating protein (GAP) for rhoa and cdc42.

215.607 kDa

MATRRATVPEQQQQQPSSPGSEISKNKDGQEQSEMVSPTEEEGFCWPGPKSVALRRASEGFGFTLRHFIVYPPESAVHTTVKDEENGNRGVNAGRPRNRLEPMDTIFVKQVKEGGPAHEAGLCTGDRIIKVNGESVIGKTYSQVIALIQNSDSTLELSVMPKDEDILQLAYSQDAYLKGNDSYSGNAQNIPEPPPICYPRTKPAASVMAQPVEVPPSGTSLTKQQSSRPVRTATTQPDRSYRVEIQVPPSPTDIVKSNTAVCVCNEAVRTVILPSEKVVDLSSNRTNRAGPLHRTEEVRYGLADPSMLKRTTSPPSSTPSVPMVPASRQFDNAGVIGKPPSYGGHSESMFSTRPSQAEESPSPTNHYASPGSHQQIDWRNYKTYKEYIDNRRMQMYGCRTIQERLDSLRAASQNTTDYDQMLPNRSSGQVRRRSTSHDRVPQSVQMRQRSVSQERLEDPVLMKEWPRSASQDTLTSLTVAPRNHRSESWDYLTRKEDFDQFIVDTQSNGEQKHNYKWTGFTEQDDQRGIYEIPRQHSFHMSLRSPNYTMAPLPYPSDSRRAGTRVLAPARPLQKVHPDLKTIQPTRNFQNSYRSPHPRPAVSERLVFPISKSNSVKIPATYASKPYSPSVGSEDGIVKDQKAVNYIHVSGPQNFQRKPQTESALGFQLDSLKTSTSASSSSPAHTKPAKQAKHSTATSQNVDGKKTQSPEANAGDSNSVLTSIDQVVLREKPSPGQQTSQPIRQPSYIFAVSDVEGASDTTCWLPNDARREVHIKRIEQKKASGSDSPGDSLASIPFIDEPTSPSIDHEIANIPASAVISISVQPLPTITTVPPSPTSPVPLIRRHFSHDHDSIRPSILEVNSKTERSKSCDEGLDDYKDEGKLSLKQGSSLKGIKARENVPSSEDSESRKDSSSDVFSDSNKEGFLYFRQLTTEKGKRVSGSMRPWKQMYVVLRGSALYLQKDKKEQSGHSSAQSDEEQLIGINGCLIDISYSETKRKNVFRLTTSDREFLFQAEDRDDMLAWIKAIQENGNLNDEQTDQASRVLISKRIKEYNTMMSSSSNKSEQSPKPSRQTLSIRQPFRATKPEGKLQSPHSPKQESERRLFSKDDISPPKDKGSWRRIMKKPFEKKPTTGGTFGVRLDDCPPAHNNKYVPLIVDVCCKLVEDRGLETTGIYRVPGNNAAISSMQEELNKGSTDIDIQDDKWRDLNVISSLLKSFFRKLPDPLFTNEKYNDFIEANRTEDPVERLKTLKRLILDLPDHHYETLKYLSAHLKAVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQQHDWFFSEESADEPITAVQEESTVESQPVPNIDHLLPNIGRTGLSPGDVSDSASDSAKSKGSWGSGKDQYSRELLVSSLFAAASRKRKKQRDKPQPSSSEDELDNVFYQKELLQVEFQRPDKQNVDKDVDLKANALSLKDADNIKGTNIIKEDKLEKDIMHSEATSPCPPKLSEPPIVNHRLPPDDKNIPQISFQMEESMSDSGTMLSTSSQASAQRSKPKVVSPELKGSDFLTADVSSITSDYSTTSSTIYIVGLDQNLISPEVQSVAESKGEEADDERSELISEGRPMETDSENDFPIFASSIAFDRQHRSKVEEPTRNVQVNSEGSPSCTEGSITPRMDRRRFSSHKLIECDTLSRKKSIRQKTDSECSAESKNEETLSDAQEAVKKGRSLSIGDTTTNNEPEEPAWRIKITERLKLRLKASADDMFGIGSQKAQAAETRKKKNIRRRHTLGGQRDFAEISVLNAWKINEPSSKEAELSAVDRLKPKCPSQDLSISDWLARERLRTSTSELSMVEPEEKRISDATSQKEPASPSPPPASSPSQVSTAIVTAGSESPSQGTAPPPDDQMNGDSFQSKNKNNFSPAVDAHPHKLSGTQVVRSRFYQYL