Protein
Cysteine desulfurase, mitochondrial
Organism
Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)
Function
Catalyzes the removal of elemental sulfur from cysteine to produce alanine (By similarity). It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters (By similarity). Plays a role in both tRNA-processing and mitochondrial metabolism (By similarity). Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs (By similarity).
Similarity
Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.
Sequence
MSNIAPQVLRHASRACSRRLSLSASLVRPAYSARTVTGSGSGGRRYVSGSQRHNAQAQTTVESAVKTEQKASVPGTAVTGDALANPSAGILKQATIMDEGNRPIYLDMQATTPTDPRVLDAMLPFLTGLYGNPHSRTHAYGWETEKATEQARSHVATLIGADPKEIIFTSGATESNNMSIKGVARFFGRSGKKKHIITTQTEHKCVLDSCRHLQDEGFEVTYLPVQSNGLIKIEDLEAAIRPETALVSIMTVNNEIGVIQPMKEIGALCRSKKVFFHTDAAQAVGKIPVDVNEWNVDLMSISGHKLYGPKGIGACYVRRRPRVRIDPLITGGGQERGLRSGTLAPPLVVGFGEACRLAKEEMEYDSKRISALSQRLLTSLLALEHTTLNGDPNRHYPGCVNVSFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGNSDESAHSSIRFGIGRFTTESEIDYVIKAVKERVTFLRELSPLWELVQEGVDLNTIEWSQH