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ARAP2

Gene
ARAP2
Protein
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Organism
Homo sapiens
Length
1704 amino acids
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).
Mass
193.452 kDa
Sequence
MSSVSEVNVDIKDFLMSINLEQYLLHFHESGFTTVKDCAAINDSLLQKIGISPTGHRRRILKQLQIILSKMQDIPIYANVHKTKKNDDPSKDYHVPSSDQNICIELSNSGSVQTSSPPQLETVRKNLEDSDASVERSQYPQSDDKLSPPKRDFPTAEEPHLNLGSLNDSLFGSDNIKIESLITKKTVDHTVEEQQTEKVKLITENLSKLPNADSECLSFVGCSTSGTNSGNGTNGLLEGSPPSPFFKFQGEMIVNDLYVPSSPILAPVRSRSKLVSRPSRSFLLRHRPVPEIPGSTKGVSGSYFRERRNVATSTEKSVAWQNSNEENSSSIFPYGETFLFQRLENSKKRSIKNEFLTQGEALKGEAATATNSFIIKSSIYDNRKEKISEDKVEDIWIPREDKNNFLIDTASESEYSTVEECFQSLRRKNSKASKSRTQKALILDSVNRHSYPLSSTSGNADSSAVSSQAISPYACFYGASAKKVKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKFEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVTPEKCGYLELRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDIHSEGVLSQESSQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELTISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKNDVPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADTIKHCSDRSTLGSIKEGILKIKEEPSKILSGNKFQDRYFVLRDGFLFLYKDVKSSKHDKMFSLSSMKFYRGVKKKMKPPTSWGLTAYSEKHHWHLCCDSSRTQTEWMTSIFIAQHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAELERLRLSEKCDKESVDSSLKERASMVAHCLEHKDDKLRNRPRKHRSFNCLEDTEPEAPLGQPKGHKGLKTLRKTEDRNSKATLDSDHKLPSRVIEELNVVLQRSRTLPKELQDEQILK
Protein
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2: ARAP2

Gene
Arap2
Protein
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2
Organism
Mus musculus
Length
1703 amino acids
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency (By similarity).
Mass
193.398 kDa
Sequence
MSSVSEVNADIRDFLMSINLEQYLLHFREFGFYTVRDCTSINDSVLHQIGISPTGHRRRILKQLQMIFSKMQDFPIYANVHKAKNGSTTKEQQHSDPSSSTHTGIECSDSITVHRPGPAPSEMVTTSTLSEGNCQSPKSHDKLCLSSHDLLCPEEELHQNVDSSKDSLFGGVNVKIDPLITKRAVEYTAGEEHTEKGNLTSEDSSKALSTNTECLPSGDCPTSGTHSGNGTNGVLESFPPTPFFQFQGEMVVNELYVPSSPVHGPMRSRSKLVSRPSRSFLLRHRPVPEIPGSTKSIPGSYFRDRRSNTTSAGKSLTLKNSNEDNSTSIFPYGETFLFQRLESSKKRSIKNEFWPHENTVKEEAATTRNSILTQSSIYDNRKEKVSEDKVEDIWIPREDKNNLAQDSASESEYSTVEECFQSLRRKNSKASKSRTQKAFYLDPFNRHSYPLSSTSGNTEPSSTISNAISPYACFYGSSAAKEKCGWLDKLSPQGKRMFQKRWVKFDGLSISHYNNDREMYSKGIIPLTAISTVRAQGDNKFEIVTTQRTFVFRVEKEEERNDWISILLSALKSPSLASQLQAAVAPEKCGYLELRGYKAKIFTVLRGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRAVKQSFEIITPYRSFSFTADSEREKQEWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDCKVRSLKMDASIWSNELIELFIVIGNKRANDFWAGNLQKDEELQVDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQYDAHFEGGSSQDAAQSSFLCDFLYQTAAAASRVSSEKKLLEDTNKKWCVLEGGFLSYYENDRCTTPNGTINISEVICLAVHKEDFYLNTGPIFVFEIYLPSERVFLFGAETSQIQRKWTETIAKRFVPFVAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLCFCLQTQEAQEERMNLRRLQELTISTMVQNGEKVDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLCKNDVPIIVNSCIAFVTQYGLGCKYIYQKDGDPLHISELLESFKKDARSVKLRAGKHQLEDVTGVLKSFLSDIDDALLTKELYPYWVSALDTQDEKERTSKYRAFIRSLPGVNRATLAALIEHLYRVQKCSEINHMNAHNLAMVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQMDIENSFITKWKDTQVSQAGDLLIEVFVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPMKGDIWATFEVIENEELERPLHYTENVLEQVLQWSSLAEPGSAYLVVKRFLTVDSIKQCREKSIKEGILKLKEEPSKILSGNKFQDRCVVLRDGHLFIYKDPKSSKHDKMFPLRAMKFYLGVKKKMKPPTSWGLTVYSEKHHWHLCCDSLQAQMEWMASIFIAQHENDIWPPAGKERKRSITKNPKIGGLPLIPIQHERNATQARKNIETARAELERLRLSEKHDPRDFTDSSLKDRASLIAHCLEHKDEKLRNRARKHRSFNCLEDTEAEGPHGLPKAYKGPKTLKKTEERNSKATLDADPKLPSKVIEELSVVLQRSRPLHKELPDEQTLQKEVK
Protein
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2: Arap2