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APOC1

Gene
Apoc1
Protein
Apolipoprotein C-I
Organism
Rattus norvegicus
Length
88 amino acids
Function
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Similarity
Belongs to the apolipoprotein C1 family.
Mass
9.861 kDa
Sequence
MRLFIALPVLIVVVAMALEGPAPAQAAPDFSSAMESLPDKLKEFGNTLEDKARAAIEHIKQKEIMIKTRNWFSETLNKMKEKLKTTFA

Gene
APOC1
Protein
Apolipoprotein C-I
Organism
Tupaia glis
Length
88 amino acids
Function
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Similarity
Belongs to the apolipoprotein C1 family.
Mass
9.804 kDa
Sequence
MRLLLSLPVLLVALSVVLERPAPAQAAPDFSSTLEGLPDKLKEFGNTLEDKAKKAIERIKQSDLPAKTRNWFTETFGKVRDTFKATFS

Gene
APOC1
Protein
Apolipoprotein C-I
Organism
Ursus maritimus
Length
88 amino acids
Function
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Similarity
Belongs to the apolipoprotein C1 family.
Mass
9.676 kDa
Sequence
MRLFLSLPVWVAVLAMVLEGPAPAQAAPEISSTLGSIPDKLKEFGNTLEDKARAAIESIKQSDIPAKTRNWFSETFNKVKEQLKTAFS

Gene
APOC1
Protein
Apolipoprotein C-I
Organism
Plecturocebus moloch
Length
86 amino acids
Function
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Similarity
Belongs to the apolipoprotein C1 family.
Mass
9.658 kDa
Sequence
MRLFLSLPVLVVALLTILEGPGPAQGAPEAVDTSTGLDKLKEFGNTLEDKVREFFNRVKESDIPAKTRNWFSETLQKVKEKLRIES

Gene
APOC1
Protein
Apolipoprotein C-I
Organism
Saimiri boliviensis boliviensis
Length
86 amino acids
Function
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Similarity
Belongs to the apolipoprotein C1 family.
Mass
9.743 kDa
Sequence
MRLFLSLPVLVVVLLMILEGPGPAQGAPESVEASSGLDKLKEFGNNLEDKVREFFKRIKESDIPAKTRNWFSETLQKVKEKLRIES

Gene
APOC1
Protein
Apolipoprotein C-I, basic form
Organism
Papio anubis
Length
83 amino acids
Function
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Similarity
Belongs to the apolipoprotein C1 family.
Mass
9.418 kDa
Sequence
MRLFLSLPVLVVVLSMVLEGPAPVQGAPDVSSALDKLKEFGNTLEDKAWEVINRIKQSEFPAKTRDWFSETFRKVKEKLKINS

Gene
APOC1
Protein
Apolipoprotein C-I
Organism
Oryctolagus cuniculus
Length
28 amino acids
Function
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification (By similarity). Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.
Similarity
Belongs to the apolipoprotein C1 family.
Mass
3.165 kDa
Fragment
single
Sequence
APDFSTLELIPDKLKEFGNTLEEKARMA