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AP4E1

Gene
AP4E1
Protein
AP-4 complex subunit epsilon-1
Organism
Homo sapiens
Length
1137 amino acids
Function
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10066790, PubMed:10436028). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal (Probable).
Similarity
Belongs to the adaptor complexes large subunit family.
Mass
127.287 kDa
Sequence
MSDIVEKTLTALPGLFLQNQPGGGPAAAKASFSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVLALYKFHLIAPNQVQHIHIKFRKALCDRDVGVMAASLHIYLRMIKENSSGYKDLTGSFVTILKQVVGGKLPVEFNYHSVPAPWLQIQLLRILGLLGKDDQRTSELMYDVLDESLRRAELNHNVTYAILFECVHTVYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYVIVNLVGKIAELAEKYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDETEDQQLRLYAVQSYLTLLDMENVFYPQRFLQVMSWVLGEYSYLLDKETPEEVIAKLYKLLMNDSVSSETKAWLIAAVTKLTSQAHSSNTVERLIHEFTISLDTCMRQHAFELKHLHENVELMKSLLPVDRSCEDLVVDASLSFLDGFVAEGLSQGAAPYKPPHQRQEEKLSQEKVLNFEPYGLSFSSSGFTGRQSPAGISLGSDVSGNSAETGLKETNSLKLEGIKKLWGKEGYLPKKESKTGDESGALPVPQESIMENVDQAITKKDQSQVLTQSKEEKEKQLLASSLFVGLGSESTINLLGKADTVSHKFRRKSKVKEAKSGETTSTHNMTCSSFSSLSNVAYEDDYYSNTLHDTGDKELKKFSLTSELLDSESLTELPLVEKFSYCSLSTPSLFANNNMEIFHPPQSTAASVAKESSLASSFLEETTEYIHSNAMEVCNNETISVSSYKIWKDDCLLMVWSVTNKSGLELKSADLEIFPAENFKVTEQPGCCLPVMEAESTKSFQYSVQIEKPFTEGNLTGFISYHMMDTHSAQLEFSVNLSLLDFIRPLKISSDDFGKLWLSFANDVKQNVKMSESQAALPSALKTLQQKLRLHIIEIIGNEGLLACQLLPSIPCLLHCRVHADVLALWFRSSCSTLPDYLLYQCQKVMEGS

Gene
Ap4e1
Protein
AP-4 complex subunit epsilon-1
Organism
Mus musculus
Length
1122 amino acids
Function
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal.
Similarity
Belongs to the adaptor complexes large subunit family.
Mass
124.845 kDa
Sequence
MSDMVERTLTALPGLFLQNQLGGPAASRAPFFSRLGGLIRGVTALSSKHEEEKLIQQELSSLKATVSAPTTTLKTMKECMVRLIYCEMLGYDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVCMALTVVSQIFPREMIPAVLPLIEDKLQHSKEIIRRKAVLALYKFYLIAPNQVQHIHTKFRKALCDRDVGVMAASLHIYLRMIKENASGYKDLTESFVTILKQVVGGKLPVEFSYHSVPAPWLQIQLLRILGLLGKDDERTSELMYDVLDESLRRAELNHNVTYAILFECVHTIYSIYPKSELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQDPSLALQHQITIIECLDHPDPIIKRETLELLYRITNAQNVVVIVQKMLEYLHQSKEEHIIISLVGRIAELAEKYAPDNVWFIQTMNAVFSVGGDVMHPDILSNFLRLLAEGFDDETEDQQLRLYAVQSYLTLLDMENTFYPQRFLQVMSWVLGEYSYLLDKESPEEVITRLYKLLMSDSISSETKAWLFAAVTKLTPQAHSSPLVEKLIQEFTVSLNTCLRQHAFELKHLHENTELMKSLLQGAQNCEDIVADASLSFLDGFVAEGLSQGAAPYKPHHQRQEEQLSQEKVLNFEPYGLSFSSSGFTGRQSPAGISLGSDISGNSAETGLKETSSLKMEGIKKLWGKEGYLPKKESGTGDKPEASHVPAEGATVENVDQATTRKDQAQGHIPSTEEKEKQLLASSLFVGLGPENTVDLLGKADVVSHKFRRKSKLKVAQSDKTPSAPTAPCSALSLGSDVAGGDEDGLSAVDRGDGELSSELFRSESLSGPPSAEKLESVSLPVPSLFADNNMEVFNPPSSSATSTVKEETPECRHSGLVEICSNEAVSVSSYKVWRDDCLLVIWAVTSKTDSEFTDAQLEIFPVENFKIIEQPECSSPVIETERTKSFQYSVQMESPCIEGTLSGFIKYQMMDTHSVQLEFSMNLPLLDFIRPLKISTEDFGKLWLSFANDVKQTIKISEPGVALTSVLTELQQNLRLRVIDVIGNEGLLACKLLPSTPCVLHCRVHADAVALWFRSSSSVLSDYLSCHCQKVMQTS

Gene
ap4e1
Protein
AP-4 complex subunit epsilon
Organism
Dictyostelium discoideum
Length
1080 amino acids
Function
Probable component of an adaptor protein complex. Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways.
Similarity
Belongs to the adaptor complexes large subunit family.
Mass
123.904 kDa
Sequence
MNSSALNLIQFLESSKIQVPGGLKSVKGILDFDFYDLVKNIGESTSREEEVHIIQNEIIKLKSCFSKEQSKDKKRECLIRMIYCHMLGYDVPFGHIQALNMTQDSEILNKRTGYLTLSLCLPERHELLIMAVNSILKGLNSSNYLEVCSALTAMCKLIDNDTIPAFLQKVLQLLNHQKPIVRKKSVTVLHRFYRLVGDSFLDDDQIIDKLRQSLCDRDPSVMSASICIFLDISEKHSTLKDNNNQINNNNNNNNSNQIKKKNNEEINRSKNLISMLKELVPSFVGILKQVAEGRLPNSYIYHGIHHPWLQINLLKLLSNLGYQDKDSSNHMYTVLLFTMQQSQKFKNNVGFAILYETIKTLTLIHPNLQLIEQCSKNIAIFLKGKHHNLRYFGIKALASIVKVSPKLVLPYQVEVIESLESPDETLKRKSFDLLYKMTNQTNVVPVCSKLIEQLVLSKDQNFKSELISQITNIAEKYSPNDIWYIDTISTVLSILPNENNKDNNNNNNNNNNNNNNYQFAYNLIRLVSEEDDIKVKQHISEIYLNNIMISNEQQQQQQQENQNNLQQFSDIYIKIMSWVISEYSNLIVSNNGVIESDIISYLCDLLEKDYQGETKSWIIIGIGKLVAQLGKSLPMLELMTKKFKSSKSLICQQRSSELNEILKNPKSMSLILPLDAYCEDIDFNKIFNKFNDYSNKVGGKQYIPYEKRKNTPLVDISDGSSSHSNEKGLNFQYPPPPDPFNPHHNQQQLYPVHQHQPPSNHQQQQQQQQQQQQQQLQLFPQQPQQPQQLLLLGEDDTINLNNNSLVPVNNDQQLQPHQHQQQQQNQQQQQQNQQQQQQQNPQYPNNQLVTVPDQNAPKPIGLPKPSKVLWTKKGFVGNKQTPPQNATPQQQQQQQQQQTQNTLSQQQIQKHQQTHNNIDPEKEKLAKQLFGGFSENNNRNENSNNTDNNQNNVGITSKLQNKKSNNENNINNNKKESYLEELIDLSPNLISNINITNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNLLLVDVEGDEQKEVKNSSCSSGNSELINLNLDENTTKNINGNLLGDDLEELNKN