Organism
Rattus norvegicus
Function
Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.
Similarity
Belongs to the peptidase M1 family.
Sequence
MDINLDPSRDDLPLMANTSHLLVKHYVLDLDVDFGSRVLEGNIVLFFGDGNRCKKQSSSSQETFQMESEEAYILRTAEPCHVPKMDSNTFSPKMGHREFAVFGKSDQDAFDNDGNHDNKEHDSESSSSKYCCDTGNHGREDFLLVLDCCDLSVLKVEEVDVAAVPDLEKFTKAPNLTAAPEKRRCEIVRDLVALPADAWREQLDCYTRCSQAPGCGELLFDSDKWSLQIRKKGVPTAADFPHAIRIWYKTKPEGQSVTWTSDQDGRPCVYTMGSPINNRALFPCQEPPVAMSTWQATVRAAASFVVLMSGEKSAKPTPLRESWHYYVTMPMPASTFTIAVGCWTEMKPKTSPLDDLTEHTLPLRPSDADFRFVFGNCSHMEYPCRFQSASAATQNIIPYRVFAPVCLEGACREALLWLIPSCLSAAHSVLGTHPFSRLDILIVPTNFPSLGMASPHIIFLSQSTLTGTSHLCGTRLCHEIAHAWFGLAIGARDWTEEWLSEGFATHLEDIFWAEAQQLPPHEALEQQELRACLRWHRLQDELQNSPEGMQVLRPNKEKTGHVSASGASVVKNGLNPEKGFMQVHYLKGYFLLRFLARTLGEETYFPFLRKFVHLFHGQLILSQDFLQMLLESIPENKRFGLSVENIVGDWLECPGIPKALQEERKAKDCSPSRLVRQVAKWIRVNRRPGKRQRRKREAAFEKLSPDQIVLLLEWLLEQKTLSPQTLHRLQQTYHLQEQDAEVRHRWCELVIKHKYTKAYDQVKRFLQEDQAMGIYLYGELMVSEDARLQQLAHRCFELVKGHMDKASAQVVTEMLF