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AND_22863

Gene
AND_22863
Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Anopheles darlingi
Length
279 amino acids
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Mass
30.473 kDa
Sequence
MGTKVKIGIIGGSGLDDSQIIENRTERVVNTHFGIPSDVLIEGKIAGVECVLLARHGRNHSIMPTNVNYRANIWALKTLGCTHVLVSTATGSLRDEIHPGDIVIPDNFIDRTTKRVQTFYDGNELLVGVCHIPMEPAFCSRTRDVLIETARELGIAGVHNSGTVVTIEGPRFSSKAESNLFRQWGAHLVNMTLVPEVVLAKEAGLCYAAIAMATDYDCWRETGEDVNVADVLATFKKNVTKVTELIINAIPKIAALDWTETIEELAKTVNTSIMLPHSN