Protein
Lipoyl synthase, mitochondrial
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Function
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Similarity
Belongs to the radical SAM superfamily. Lipoyl synthase family.
Sequence
MAAATNRFRALYSSSRVATPQAGSASYLSYRGYATTDPSSATGGASTAGKRRTTFTDKLNAGPSFGDFVSGGRDNAPLDPSEAYALKTALVGPAGRKKEMTRLPSWLKTPIPDSKNYQRLKKDLRGLNLHTVCEEARCPNISDCWGGGDKAAATATIMLMGDTCTRGCRFCSVKTSRAPPPLDPHEPENTAEAISRWGLGYVVLTSVDRDDLADGGARHFAETVIKIKQKAPNILVECLTGDYAGDLEMVGVVARSGLDVYAHNVETVEALTPHVRDRRATFQQSLRVLEAAKKAKPSLITKTSLMLGLGETEEQLWDALRQLRAVNVDVVTFGQYMRPTKRHMAVHEYVTPDRFELWRQRALDMGFLYCASGPLVRSSYKAGEAFIENVLKKRRSGAPEVSHNTVPVDEATR