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AN5861

Gene
AN5861
Protein
Very-long-chain 3-oxoacyl-CoA reductase
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
346 amino acids
Function
Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.
Similarity
Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Mass
37.679 kDa
Sequence
MEYLKDISSSLSGWEFNFAPGWQSVTASVLLVAGGWFVVSRVWTFLRVLTSLFVLPGKSLRSFGPKGSWAIVTGASDGLGKEFALQIARAGYNIVLVSRTASKLTALTDEITSKYPSVQTKMLAMDFARNLDEDYEKLKALIQDLDVAILINNVGKSHSIPVPFALTPEDELADIITINCMGTLRVTQLVVPGMTQRKRGLILTMGSFGGLVPSPLLATYSGSKAFLQQWSTALGSELQPYGITVELVQAYLITSAMSKIRKTSALIPNPRAFVKATLSKIGNNGGSPGYAYSSSPYWSHGLVAYLATCVINPMSKWLANQNKAMHESIRKRALRKAERENAKKSS