Protein
NAD-dependent protein deacetylase hst1
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Function
NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability.
Similarity
Belongs to the sirtuin family. Class I subfamily.
Sequence
MDLASAPRGESPPLKAPLVEIEAAEVERSLPQENAAPEEKGSNSQSEYESDSDALDDEWETQSLYEDAIQMIRDDQLRDGTIPGACTLEEAIEFRKRLHEVGKAQFVEETIARDTVTAKKLCTAFGILPPSFLEGAPDEAYHPLLAIAISREFARRQKLPQYNSVDDAVKLLKESKNIIVLTGAGISTSLGIPDFRSKDTGLYSKLENLGLNDPQEVFDIRIFREDPGIFYSIAKDILPTEKKFSPTHGFIRLLQDKGKLLTNYTQNIDNIEANAGVFPENIVQCHGSFATATCVKCQYKVAGDEIYDDIKKGLIPECAQCRKRIAEDSQKPQGQKRKRNSTSAHKDRSKSGEDSSDGEDYEIPTPGVMKPDITFFGEDLPDEFGRRLLHHDRDKVDLVIVIGTSLKVAPVAEVPGVLPPHIPQIYISRTPVAHTNFDIDLLGDCDVVVSELCRRAGWELKHEMISPDEKVDVTPVFGYGSRHVFKVSG