AMN

Gene

amn

Protein

AMP nucleosidase

Organism

Escherichia coli O157:H7

Length

484 amino acids

Function

Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.

Similarity

Belongs to the AMP nucleosidase family.

Mass

53.995 kDa

Sequence

MNNKGSGLTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSLTVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQDYGAHISVQPSQHEIPYPYVIDGSELTLDRSMSAGLTRYFPTTELAQIGDETADGIYHPTEFSPLSHFDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILDPDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGITLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHAYLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTLLCVSDKPLHGEIKLPGQANRFYEGAISEHLQIGIRAIDLLRAEGDRLHSRKLRTFNEPPFR

Protein

AMP nucleosidase: amn

Gene

amn

Protein

AMP nucleosidase

Organism

Escherichia coli (strain K12)

Length

484 amino acids

Function

Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations.

Similarity

Belongs to the AMP nucleosidase family.

Mass

53.995 kDa

Sequence

Protein

AMP nucleosidase: amn

Gene

AMN

Protein

Protein amnionless

Organism

Canis lupus familiaris

Length

458 amino acids

Function

Necessary for efficient absorption of vitamin B12 (By similarity). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity).

Mass

47.618 kDa

Sequence

MGALGRALLWLQLCALARAAYKLWVPTTDFEAAANWSQNRTPCAGAVVQFPADKAVSVVVRASHGFSDMLLPRDGEFVLASGAGFGAADAGRDPDCGAGAPALFLDPDRFSWHDPRLWRSGDAARGLFSVDAERVPCRHDDVVFPPDASFRVGLGPGARPARVRSVQVLGQTFTRDEDLAAFLASRAGRLRFHGPGALRVGPGACADPSGCVCGDAEVQPWICAALLQPLGGRCPPAACPDALRPEGQCCDLCGAIVSLTHGPTFDIERYRARLLRAFLPQYPGLQAAVSKVRRRPGPHTEVQVVLAETGPQPGGAGRLARALLADVAEHGEALGVLSATARESGAPVGDGSAAGPLGSGSRAGLAGGVAAGLLLLLLALAAGLLLLRRAPRLRWTKRERLVATPVEAPLGFSNPVFDVAGSVGPVPRTPQPPPAQQAGSSSTSRSYFVNPLFAEAEA

Protein

Protein amnionless: AMN

Gene

Amn

Protein

Protein amnionless

Organism

Mus musculus

Length

458 amino acids

Function

Necessary for efficient absorption of vitamin B12 (By similarity). Required for normal CUBN-mediated protein transport in the kidney (PubMed:15342463). May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm.

Mass

48.696 kDa

Sequence

MGALGRVLLWLQLCAMTRAAYKLWVPNTSFDTASNWNQNRTPCAGDAVQFPADKMVSVLVRDSHAISDMLLPLDGELVLASGAALSAAGGDSDPACNPGAPLLFRNPDRFSWLDPHLWSSGTQAPGLFSVDAERVPCSYDDVLFPRDGSFRVALGPGPNPVHVRSVSAVGQTFSRDEDLTAFLASREGRLRFHGSGALRVGSQACTDASGCVCGNAEMLPWICASLLQPLGGRCPQAACQDPLLPQGQCCDLCGAIVSLTHDPTFDLERYRARLLDLFLKQPQYQGLQVAVSKVLRDAHTEIQVVLVETEHATGAAGQLGHALLQDAVAQGSVLGIVSATLRQSGKPMTADSELNQSSSGAGLAGGVAALVLLALLGTVLLLLHRSGRLRWRRHEDAEPVSAGLPLGFRNPIFDAIVFKQQPSVELPDSAQKVDILDIDTKFGCFVNPLFAGEAEAEA

Protein

Protein amnionless: Amn

Gene

AMN

Protein

Protein amnionless

Organism

Homo sapiens

Length

453 amino acids

Function

Necessary for efficient absorption of vitamin B12 (PubMed:12590260, PubMed:14576052). Required for normal CUBN-mediated protein transport in the kidney. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity).

Mass

47.754 kDa

Sequence

MGVLGRVLLWLQLCALTQAVSKLWVPNTDFDVAANWSQNRTPCAGGAVEFPADKMVSVLVQEGHAVSDMLLPLDGELVLASGAGFGVSDVGSHLDCGAGEPAVFRDSDRFSWHDPHLWRSGDEAPGLFFVDAERVPCRHDDVFFPPSASFRVGLGPGASPVRVRSISALGRTFTRDEDLAVFLASRAGRLRFHGPGALSVGPEDCADPSGCVCGNAEAQPWICAALLQPLGGRCPQAACHSALRPQGQCCDLCGAVVLLTHGPAFDLERYRARILDTFLGLPQYHGLQVAVSKVPRSSRLREADTEIQVVLVENGPETGGAGRLARALLADVAENGEALGVLEATMRESGAHVWGSSAAGLAGGVAAAVLLALLVLLVAPPLLRRAGRLRWRRHEAAAPAGAPLGFRNPVFDVTASEELPLPRRLSLVPKAAADSTSHSYFVNPLFAGAEAEA

Protein

Protein amnionless: AMN

Gene

amn

Protein

Amnesiac neuropeptides

Organism

Drosophila melanogaster

Length

180 amino acids

Function

Required for associative learning and memory in adults. Expression pattern suggests a modulatory role in memory formation. Controls neurotransmitter-mediated signaling pathways associated with the structure of the larval peripheral nerve.

Mass

20.399 kDa

Sequence

MRSFCCCFYPAAVALHCVLLFYTFFLLFRASALRRRVVSGSKGSAALALCRQFEQLSASRRERAEECRTTQLRYHYHRNGAQSRSLCAAVLCCKRSYIPRPNFSCFSLVFPVGQRFAAARTRFGPTLVASWPLCNDSETKVLTKWPSCSLIGRRSVPRGQPKFSRENPRALSPSLLGEMR

Protein

Amnesiac neuropeptides: amn