Function
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex (By similarity).
Sequence
METGRSRGGGAAVSERGGGARAGVCGRQEQAGALAADMDSHCECAAETPAAEPPSGKINKAAFKLFKKRKSGGTMPSIFGVKNKGDGKSSGPTGMVRSRTHDGLAEVLVLEGSKKEEPPGGSDHSGARPIPGPPKPSGPGLGSLASSSVAKSHSFFSLLKKNGRSETGKGDHAEASKAGGKQKRGLKGIFSSMRWHRRDKRGKEEEEKAVRAAGPGNLVLPGSLTASLECVKEEPPRAARRPDSPGQDASRHAAGEPAGGEQAPASAESAPERICLEAGSPTGSGDQSSRGEDAEGHRREEKPGAALESGAGEVQAAEDASKTGDVPIKTVPLVDSEGGSGRASAVPDPSSVDPPSDPSADRICLMFSDVTSLKSFDSLTGCGDIIADPEEEAGPSCDKHVPGPGKPVLSKKNASVVAYQGGGEEMASPDQVDDTYLPEFWDMLSQTEDQGQGTQEGAAKAATASDIKLAPETSSDTRCGEAAKDMSSVKRRRLHRIPIESQQKEEPKHPEKEHQEGVPNSDEGYWDSTTPGPEEESISNSSSSKKVVIPRDSDSGDALCDLYVEPEASPATLPATEDPPCLSRLKPVSPGTITCPLRTPGSLLKDSKIPISIKHLSNLPSSHPVVHQQPARSEVPRTKIPVSKVLVRRVSNRGLAGTTIRAAACHDSAKKL