AGTPBP1

Cytosolic carboxypeptidase 1

1226 amino acids

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

Belongs to the peptidase M14 family.

138.448 kDa

MSKLKVIPEKSLTNNSRIVGLLAQLEKINAEPSESDTARYVTSKILHLAQSQEKTRREMTAKGSTGMEILLSTLENTKDLQTTLNILSILVELVSAGGGRRVSFLVTKGGSQILLQLLMNASKESPPHEDLMVQIHSILAKIGPKDKKFGVKARINGALNITLNLVKQNLQNHRLVLPCLQLLRVYSANSVNSVSLGKNGVVELMFKIIGPFSKKNSSLIKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSLKSVTNIKLGRKAFIDANGMKILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSSFHFQLPVIPVTGPVAQLYSLPPEVDDVVDESDDNDDIDVEAENETENEDDLDQNFKNDDIETDINKLKPQQEPGRTIEDLKMYEHLFPELVDDFQDYDLISKEPKPFVFEGKVRGPIVVPTAGEETSGNSGNLRKVVMKENISSKGDEGEKKSTFMDLAKEDIKDNDRTLQQQPGDQNRTISSVHGLNNDIVKALDRITLQNIPSQTAPGFTAEMKKDCSLPLTVLTCAKACPHMATCGNVLFEGRTVQLGKLCCTGVETEDDEDTESNSSVEQASVEVPDGPTLHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKIAQDIERLIHQSDIIDRVVYDLDNPNYTIPEEGDILKFNSKFESGNLRKVIQIRKNEYDLILNSDINSNHYHQWFYFEVSGMRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARPWWIRMGTDICYYKNHFSRSSVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYSTLQMHLQKLESAHNPQQIYFRKDVLCETLSGNSCPLVTITAMPESNYYEHICHFRNRPYVFLSARVHPGETNASWVMKGTLEYLMSNNPTAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQSPSPDLHPTIYHAKGLLQYLAAVKRLPLVYCDYHGHSRKKNVFMYGCSIKETVWHTNDNATSCDVVEDTGYRTLPKILSHIAPAFCMSSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGKYKGLQIGTRELEEMGAKFCVGLLRLKRLTSPLEYNLPSSLLDFENDLIESSCKVTSPTTYVLDEDEPRFLEEVDYSAESNDELDIELAENVGDYEPSAQEEVLSDSELSRTYLP

agtpbp1

Cytosolic carboxypeptidase 1

1226 amino acids

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate.

Belongs to the peptidase M14 family.

138.681 kDa

MSKAKATADKCLSNNSRIQSLLSQLEKVNAEPLLFDSDNTRYVTAKILHLAQTQEKTRKEIAAKGSTGMEVILCTLENTRDLQTILNILNILNELASTAGGRRINALISKGGSRILLQLLLSASKESSSNEELMMVLHSLLAKVGPKDKKFGIKARVSGALNISLNLVKQNLQNPRLILPCLQVLRVCCMNSVNSVYLGKNGAVEILFKLIGPFTRRNTGLIKVSLDTFAALLKSKTNARKAVDRGYVQALLSIYTDWHRHDTRHRHMLIRKGILQCLKSITNIKIGRKAFIDANGMKTLYNTSQECQAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSAFQFQLPIMPTSGPVALLYSMPPEVDDVVDESDDNDDTEAETEAEAENEESDQLCKNDDIETDITKLIPGQELGRTLEDLKMYERFFPELTEDFQEFDLVSNEPKPGAKLGPIIVPTAGEEQPEVPNNFMKDLEKRSCNISLEDECNKRPTFLDMPKNVTNKGNDGLGQQVHGDIDRSCYYFSSDIVKDLEKLSLRKPSGNHPCRNGCVSAKDKPIFLPHPCNKSTSNSGSCSNNLFEKHSMHLSPLCCSGITPDDDESSPLDELAMREITDFDNLLPLHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHVPPFFKERLLERPYGVQRSKIFQDIERMIHPNDIIDRVVYDLDNSSCSAQDESEVLKFNSKFESGNLRKVIQIRKNEYDLILNSDINSNHYHQWFYFEVSGMRTGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALASRPWWYRVGMDICYYKNHFSRSSIATGGQKGKSYYTITFTVTFPHRDDVCYFAYHYPYTYSTLKMHLKKLESLHNPQQVYFRQEVLCETLGGNGCPVITITAMPESNYYEHVYQFRNRPYIFLSSRVHPGETNASWVMKGTLEFLMGSSTSAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQNPNVDLHPTIYHTKGLLQYLAAIRRTPLVYCDYHGHSRKKNVFMYGCSIKETVWHTNANAASCDMVEDSGYRTLPKVLNQLAPAFSMSSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGKYKDLQIGTKELEEMGAKFCVGLLRLKRLTSPMELTLPPSLIDIENELIESSCKVASPTTYVLEDDEPRFLEEVDYSAESNDDADPDLPDTIGDFENTALEEEGFSDSEITRTHTSGQST

agtpbp1

Cytosolic carboxypeptidase 1

1225 amino acids

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate.

Belongs to the peptidase M14 family.

138.782 kDa

MSKVKATAEKCQLNISRIQSLLSQLEKVNAESLLFDTDNTRYVTAKIFHLAQTQEKTRKEMTAKGSTGIEVILCTLENTRDLQTILNILNILNELASTAGGRRINALISKGGARILLQLLLSASKESPSNEELMIVLHSLLAKLGPKDKKFGVKARVSGALNISLNLVKQNLQNPRLILPCLQVLRVCCMNSVNSAYLGKNGAVEILFKIIGPFTRRNTGLIKVSLDTLAALLKSRTNARKAVDRAYVQTLISTYMDWHRHDTRHRHMLIRKGILQCLKSITNIKIGRKAFIDANGMKTLYNTSQECQAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSAFQFQLPFMPTSGPVALLYSMPPEVDDVVDESDDNEDTDAETEAEAENEDSDQICKNDDIETDITKLIPGQELGRTLEDLKMYERFFPELTEDFQEFDLVSNEPKPGAKLGPIIVPTAGEEQPEVPNNFMKNLARRSCNISLEDESNQRPTFLDMSKNVTNKGNSLDQKVHVDKDGSCYYYSNDIVRDLEKLSLHKASGNHPCRNGCVSAKDKPNFLPHPCNKSTSSSISCSNSLFEKHSMHLGPLCCSGIAPDDDESSPLDEQVMREMTDFDSILPLHDPDLYIEIVKNTKSVPEYTEVAYPDYFGHVPPFFKERLLERPYGVQRSKIFQDIERMIHPNDIIDRVIYDLDNPSCSAHDEIDILKFNSKFESGNLRKVIQIRKNEYDLILNSDINSNHYHQWFYFEVSGMRTGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALASRPWWYRVGTDICYYKNHFSRSSLATGGQKGKSYYTITFTVTFPHKDDVCYFAYHYPYTYSTLKMHLQKLESLHSPQQIYFRQEVLCETLGGNGCPVITITAMPESNYYEHVYQFRNRPYIFLTSRVHPGETNASWVMKGTLEFLMGSSATAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQNPNSDLHPTIYHTKGLLQYLSAIKRVPLVYCDYHGHSRKKNVFMYGCSIKETVWHTNANAASCDMVEESGYKTLPKVLNQIAPAFSMSSCSFVVEKSKESTARVVVWKEIGVQRSYTMESTLCGCDQGKYKDLQIGTKELEEMGAKFCVGLLRLKRLTSPMELTLPPSLIDIENELIESSCKVASPTTYVLEDDEPRFIEEVDYSAESNDDVDPDLPENIGDFETSTLEEESFSDSEITRTHMSGQST

AGTPBP1

Cytosolic carboxypeptidase 1

1224 amino acids

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate.

Belongs to the peptidase M14 family.

137.742 kDa

MKVKKNLTCSVSTSSRTMSLLSQLEKINLDSVLGEADNARYVTAKILHLVQSQEKTKKEMTSKGSSAIEVILSTLENTRDPQTILNILSILIELVSVGGGRRASVLVTKGGTQILLQLLLNASKESPPNEELMVLLHTLLAKIGPKDKKIGMKARINGALNISLNLVKQNLQNHRLILPCLQVLRVYSTNSVNAVSLGKNGVVELMFKIIGPFSKKNTSLMKVALDTLAALLKSKTNARRAVDRGYVHMLLTIYVDWHRHDSRHRYMLIRKGVLQCIKSVTNIKLGRKAFIDANGMKILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSAFHFQLPVIPASGPVAQMYNLPPDVDDVVDESDDNDDAETESEIETEDDKDQNFKNDDIETDINKLKPRQELGRPLEELKMYEQFFPELTENFQECDLVSKEPKPFVSNANLGGPIVVPTAGEEFSAETNPSVIGISLKEGNPLLTEEYNRRPAFLGLPKKDSIKASSLLQQNVQRNLLPSCQCLSQEIVTGLDRISLQNTSENDQYYATGCVIKKDNKTSLTPLACSKTCEHVSPCGSSLFEGSSVHLGKFCCTGVESEEEDSKSSSSGEQVVLEVSDVSPVHDCDLYIEMVKTTKSIPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKISQDIERLIHQNDIIDRVVYDLDNSICSAPEEVDVLKFNSKFESGNLRKVIQIRKNEYDLILNSDINSNHYHQWFYFEVSGMKTGIGYRFNIINCEKSNSQFNYGMQPLMYSVQEALNSRPSWTRVGTDICYYKNHFSRSSIAAGGQKGKSYYTITFTVTFQHKDDVCYFAYHYPYTYSTLKMHLQKLESMHNPQQIYFRQDALCETLGGNICPIVTITAMPESNYYEHICQFRNRPYIFLSARVHPGETNASWVMKGTLEYLMSSNPSAQSLRESYIFKIIPMLNPDGVINGNHRCSLSGEDLNRQWQNPNPDLHPTIYHAKGLLQYLAAIKRLPLVYCDYHGHSRKKNVFMYGCSIKETMWHTNVNTASCDLMEDPGYRVLPKILSQTAPAFCMGSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGKYKGLQIGTKELEEMGAKFCVGLLRLKRMASPLEYNLPSGLLDIENELIESSCKVTSPTTYVLDEDEPRFLEEVDYSAESNDDQDAELADNVGDYEANNQEDGLSDSDSTRILLS

Agtpbp1

Cytosolic carboxypeptidase 1

1218 amino acids

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. Deglutamylation plays a key role in cerebellar Purkinje cell differentiation, accumulation of tubulin polyglutamylation causing neurodegeneration.

Belongs to the peptidase M14 family.

137.197 kDa

MSKLKVVGEKSLTNSSRVVGLLAQLEKINTDSTESDTARYVTSKILHLAQSQEKTRREMTTKGSTGMEVLLSTLENTKDLQTVLNILSILIELVSSGGGRRASFLVAKGGSQILLQLLMNASKDSPPHEEVMVQTHSILAKIGPKDKKFGVKARVNGALTVTLNLVKQHFQNYRLVLPCLQLLRVYSTNSVNSVSLGKNGVVELMFKIIGPFSKKNSGLMKVALDTLAALLKSKTNARRAVDRGYVQVLLTIYVDWHRHDNRHRNMLIRKGILQSLKSVTNIKLGRKAFIDANGMKILYNTSQECLAVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSSFHFQLPIIPVTGPVAQLYSLPPEVDDVVDESDDNDDIDLEVENELENEDDLDQSFKNDDIETDINKLRPQQVPGRTIEELKMYEHLFPELVDDFQDYELISKEPKPFVFEGKARGPIVVPTAGEEVPGNSGSVKKGVVMKERASPKGEEAKEDPKGHDRTLPQQLGGQSRVAPSAHSFNNDLVKALDRITLQNVPSQVASGLNAGMRKDFGLPLTVLSCTKACPHVAKCGSTLFEGRTVHLGKLCCTGVETEDDEDTESHSSTEQAPSVEASDGPTLHDPDLYIEIVKNTKSVPEYSEVAYPDYFGHIPPPFKEPILERPYGVQRTKIAQDIERLIHQNDIIDRVVYDLDNPTYTTPEEGDTLKFNSKFESGNLRKVIQIRKSEYDLILNSDINSNHYHQWFYFEVSGMRPGVAYRFNIINCEKSNSQFNYGMQPLMYSVQEALNARPWWIRMGTDICYYKNHFSRSSVAAGGQKGKSYYTITFTVNFPHKDDVCYFAYHYPYTYSTLQMHLQKLESAHNPQQIYFRKDVLCETLSGNICPLVTITAMPESNYYEHICQFRTRPYIFLSARVHPGETNASWVMKGTLEYLMSNSPTAQSLRESYIFKIVPMLNPDGVINGNHRCSLSGEDLNRQWQSPNPELHPTIYHAKGLLQYLAAVKRLPLVYCDYHGHSRKKNVFMYGCSIKETVWHTHDNSASCDIVEDMGYRTLPKILSHIAPAFCMSSCSFVVEKSKESTARVVVWREIGVQRSYTMESTLCGCDQGRYKGLQIGTRELEEMGAKFCVGLLRLKRLTSSLEYNLPSNLLDFENDLIESSCKVTSPTTYVLDEDEPRFLEEVDYSAESNDELDVELAENTGDYEPSAQEEALSDSEVSRTHLI

agtpbp1

Cytosolic carboxypeptidase 1

1153 amino acids

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate.

Belongs to the peptidase M14 family.

129.792 kDa

MNKPKMAAEKSASRVLMLLSQLERLNEESRVSDNDAIRQVTGKILHLIQTQEKTRKEVGSKGSGGMEIILSSLENTRDLQTTLNILGILNELLTVGGGRRTGLFVSKGGTAILLQLLVSSSKDPPANEELMLHIHSLLVKVGPKDRKFGVKARLNGALNVTLNLAKHNLQNYKLLLPCLQVLRVYSSNSVNAVSLGKSGALEILFEIVGPFSKKSTTLLKVALDTLAALLKSGMNARRAVDRGYLPTLLAIYQDWHRNDTRHRHVIIRKSILGCIKNITNIKLGRKAFIEASGMRILYNTSTECLPVRTLDPLVNTSSLIMRKCFPKNRLPLPTIKSVFLYPLPHIPAGGPVAQLYNQPPGVDDVVDESDENEATEVDTENDTENEEDDTGHKTQNDDIETDINKLRPKQMNTRPFEELRVYEHFCREFTETFQDIDFEDSISAIPPSRVNSELHRPIIIPTTQSSPGLQNRRPLRESALPLKPEQSPLELDSISIAKRPDGRADADLVCSLGHLILDAAVNGGSVDGCQDDGGEQSVLEVPDTAALLPLHDPELYLEMVKSTRSVPGYTEVAYPDYFGHVALNLREPILERVYGVQRTKIFQDIERLIHSSDILDKVVYDLDNQSSPLTDNGESLKFNSKFESGNLRKAIQVRKFEYDLILNSDINSNHYHQWFYFEVGNMRPGVRYRFNIINCEKSNSQFNYGMQVIMYSVQEAINGSPHWVRTGSDICYYKNHFARSSIAAGGQKGKSYFTMTFTVTFQHKDDVCYFAYHYPYTYSMLKMHLQKLSALCTPEIYYRQEDLCETLGGNGCPLLTITAMPESSSDEHISQFRSRPVIFLSARVHPGETNSSWVMKGSLEFLMSCSPQAQSLRQSYIFKIMPMLNPDGVINGNHRCSLSGEDLNRQWQNPNAELHPTIYHAKSLLQYLRATGRTPLVFCDYHGHSRKKNVFMYGCSIKETMWQSSVNTSTCDLNEDLGYRTLPKLLSQMAPAFSLSSCSFVVERSKEATARVVVWREIGVQRSYTMESTLCGCDQGKYKGLQIGTSELEEMGSQFCLALLRLRRFTSPLELHNHNSHLLDMENELIDTRHIPNITSPTTYVLDEDEPAFLEEVDYSAESNDENDPELEPDLRDNHALPDPSSDSELSHQDSLT