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AGRP

Gene
AGRP
Protein
Agouti-related protein
Organism
Bos taurus
Length
134 amino acids
Function
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Mass
14.706 kDa
Sequence
MLTAVLLSCALLLAMPPLQGAQMGPAPLEGIGRPEEALFLELQGLSLQPSLKRITEEQAEESLLQEAEAKALAEVLDPEGRKPRSPRRCVRLHESCLGHQVPCCDPCATCYCRFFNAFCYCRKLGTTTNPCSRT

Gene
AGRP
Protein
Agouti-related protein
Organism
Sus scrofa
Length
134 amino acids
Function
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Mass
14.681 kDa
Sequence
MLTTMLLSCALLLAMPTMLGAQIGLAPLEGIGRLDQALFPELQDLGLQPPLKRTTAERAEEALLQQAEAKALAEVLDPEGRKARSPRRCVRLHESCLGHQVPCCDPCATCYCRFFNAFCYCRKLGTATNPCSRT

Gene
AGRP
Protein
Agouti-related protein
Organism
Homo sapiens
Length
132 amino acids
Function
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R (By similarity). Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
Mass
14.44 kDa
Sequence
MLTAAVLSCALLLALPATRGAQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT

Gene
Agrp
Protein
Agouti-related protein
Organism
Mus musculus
Length
131 amino acids
Function
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity (By similarity). It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner (By similarity).
Mass
14.432 kDa
Sequence
MLTAMLLSCVLLLALPPTLGVQMGVAPLKGIRRPDQALFPEFPGLSLNGLKKTTADRAEEVLLQKAEALAEVLDPQNRESRSPRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTATNLCSRT