Protein
Cytosolic Fe-S cluster assembly factor NUBP2 homolog
Organism
Anopheles gambiae
Function
Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.
Similarity
Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.
Sequence
MLDKVKHIILVLSGKGGVGKSTVSTQLALTLAEADHKVGLLDIDLCGPSVPYLLGLEDRDVHQCDEGWVPVYTSAEKRLAVMSIGFLLKNRSDAVIWRGPKKTAMIKQFLEDVNWDELDYLIIDTPPGTSDEHITVMECLKTVRTEGAIIVTTPQEMALEDVRKEVTFCKKTGIPILGIVENMSGFVCPNCSECTNIFSSGGGHSLAELAKVPHLGTLPIDPRVGELAGTGKACVKELPDCTTSEVLRELVRTLTTVGQ