Protein
Digeranylgeranylglycerophospholipid reductase
Organism
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)
Function
Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains. Is not active with NADPH as an electron donor. Is not able to reduce the prenyl group of respiratory quinones.
Similarity
Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.
Sequence
MYDVVVVGAGPAGSMAAKTAAEQGLKVLLVEKRQEIGTPVRCAEGISRESIEKFFEVDKKWIAAEVTGAKIYAPNKTEIVMSEEMAGNEVGYVLERKIFDRHVARLAAKAGAEVYVKTAMVDFERKDGKVKVKLRRLGEDWEVETKILIGADGVESKIGRKAGIIKTLKLNEVESCAQYLMTGLDIDESYTYFYLGRELAPGGYAWIFPKGNGSANVGIGVLPKMAERTAKEYLDAFIEKEGIEGKIVEFVAGAVPVYGEIETAVADNIMLAGDAAYHADPITGGGIANALSAGYYAGKVAAEAVQKNDFSADFLRRYDELWKNDFGKKLRRNKKLQLKFIDMDDALLNKLAGAIAGKNLREMSVAAIVKELLKAHPKLLWDLKDLF