Protein
Methionine aminopeptidase 2-3
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Function
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Similarity
Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.
Sequence
MAAQVSEKLQDLHLNGLNGDAKSNATVIGQTEAGEAEDDSDDEKEDGNTAPEAGAGGGAYLHVWVIFEMPVSQALGMLAYNSRIPAAKKKKRKSKKKKKGGAKVQSSPPRVPVSNLFPNNQYPEGEIVEYKNENSYRTTNEEKRYLDRMNNNFLQEYRQAAEVHRQVRQYAQKTIKPGQTLTEIAEGIEDAVRALTGHQGLEEGDNLKGGMGFPCGLSINHCAAHYTPNAGNKMVLQQGDVMKVDFGAHINGRIVDSAFTMTFDPVYDPLLEAVKDATNTGIREAGIDVRMSDIGAAIQEAMESYEVELNGTMYPVKCIRNLNGHNIDRHIIHGGKSVPIVKGSDQTKMEEGETFAIETFGSTGKGYVREDMETSHYALIPDAPSVPLRLSSAKNLLNVINKNFGTLPFCRRYLDRLGQEKYLLGLNNLVSSGIVQDYPPLCDVKGSYTAQFEHTILLRPTVKEVISRGDDY