Protein
Succinate dehydrogenase assembly factor 2, mitochondrial
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Function
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.
Similarity
Belongs to the SDHAF2 family.
Sequence
MSAPRLIQRFARPSLSPFFLRTTLARRSFGSSAIRPKDDNGRAPSTAPEHREYQTNRPPNQHVPNTTSTMTRDFPKAGEKSVPPEFVSAADPNYKPADPYPGKVEHFTGGRQETGAQKPELGVGEMEGITFKVEPLKRTGEDVSTIRARLLYQSRKRGILESDLLLSTFADVYLSKMNKEQLQEYDRFLDENDWDIYYWATQDPPTEDNVAEDTPTETWKRTGAKSGEWAQTVGAYKAAYRPVPSRWADSEVLRLLRQHVQDNSATGFHAAKSKKTGGAGLGRMPNVQVFDS