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ADR

Gene
ADR
Protein
Adenoregulin
Organism
Phyllomedusa bicolor
Length
81 amino acids
Function
Enhances binding of agonists to adenosine A1 receptors, adenosine A2a receptors, alpha-2 adrenergic receptors and 5-hydroxytryptamine 1A receptors. Enhances guanyl nucleotide exchange which may result in the conversion of receptors to a high affinity state complexed with guanyl nucleotide free G-protein. Affects human behavior eliciting profound malaise, followed by listlessness and then euphoria. Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Lacks hemolytic activity. Probably acts by disturbing membrane functions with its amphipathic structure.
Similarity
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
Mass
8.844 kDa
Sequence
MAFLKKSLFLVLFLGLVSLSICEEEKRENEDEEEQEDDEQSEMKRGLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAVGEQ

Gene
ADR
Protein
Adenoregulin
Organism
Phyllomedusa bicolor
Length
81 amino acids
Function
Enhances binding of agonists to adenosine A1 receptors, adenosine A2a receptors, alpha-2 adrenergic receptors and 5-hydroxytryptamine 1A receptors. Enhances guanyl nucleotide exchange which may result in the conversion of receptors to a high affinity state complexed with guanyl nucleotide free G-protein. Affects human behavior eliciting profound malaise, followed by listlessness and then euphoria. Possesses a potent antimicrobial activity against bacteria, fungi and protozoa. Lacks hemolytic activity. Probably acts by disturbing membrane functions with its amphipathic structure.
Similarity
Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.
Mass
8.844 kDa
Sequence
MAFLKKSLFLVLFLGLVSLSICEEEKRENEDEEEQEDDEQSEMKRGLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAVGEQ