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ADI1

Gene
ADI1
Protein
Aconitate-delta-isomerase 1
Organism
Ustilago maydis
Length
443 amino acids
Function
Aconitate-delta-isomerase; part of the gene cluster that mediates the biosynthesis of itaconic acid and 2-hydroxyparaconate (PubMed:26639528, PubMed:27750034). Cis-aconitate is secreted by the mitochondrial tricarboxylate transporter MTT1. In the cytosol cis-aconitate is converted into trans-aconitate via isomerization by the aconitate-delta-isomerase ADI1 (PubMed:26639528). Decarboxylation of trans-aconitate by the trans-aconitate decarboxylase TAD1 then leads then to the production of itaconic acid (PubMed:26639528). The cytochrome P450 monooxygenase CYP3 further converts itaconate to 2-hydroxyparaconate via oxidation of the double bond, leading to a transient epoxide, which can subsequently be lactonized to produce 2-hydroxyparaconate (PubMed:27750034). Secretion of itaconate and possibly 2-hydroxyparaconate into the medium is mediated by the major facilitator ITP1 (PubMed:26639528, PubMed:27750034). The glyoxalase domain-containing protein RDO1 is not involved in the biosynthesis of itaconate and 2-hydroxyparaconate, however, it might play a role in the further conversion of 2-hydroxyparaconate to itatartarate (PubMed:27750034).
Similarity
Belongs to the PrpF family.
Mass
47.285 kDa
Sequence
MLHPIDTTIYRAGTSRGLYFLASDLPAEPSERDAALISIMGSGHPLQIDGMGGGNSLTSKVAIVSASTQRSEFDVDYLFCQVGITERFVDTAPNCGNLMSGVAAFAIERGLVQPHPSDTTCLVRIFNLNSRQASELVIPVYNGRVHYDDIDDMHMQRPSARVGLRFLDTVGSCTGKLLPTGNASDWIDGLKVSIIDSAVPVVFIRQHDVGITGSEAPATLNANTALLDRLERVRLEAGRRMGLGDVSGSVVPKLSLIGPGTETTTFTARYFTPKACHNAHAVTGAICTAGAAYIDGSVVCEILSSRASACSASQRRISIEHPSGVLEVGLVPPENAAQSLVDVAVVERSVALIAHARVYYTTPDRRRSYDSPLTSPSTPADTHNLFDAAYRPVIQPSDTDVEAPHMLALENKEQCVSRCDTALHHIVASYGASDAHASDRSLS

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
187 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.382 kDa
Sequence
MKAYIYDDKPGDQRLPHDTGIDIPEPTLAKLGVVYQRIPIDSEGAWESKIDEFAKERGYKNRDRITVTREGLGEAYEEKIKSFFDEHLHEDEEIRYILAGSGYFDIRGAEGVHEEQWIRIALEAGDLIVLPAGIYHRFTVDSANTITAMRLFQDEPKWTPYSRKADGTDKLGSRDKYLETVRVGVTA

Gene
Adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Drosophila melanogaster
Length
186 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
22.255 kDa
Sequence
MVQVWYMDTEETDQRLEHHRNPPAYLELDDLYQKTGVEYFKINADEYQSDNTLTELRAKRGYTYDDEITCSEKCLPDYANKLKAFFTEHLHTDEEIRLILEGSGYFDVRDNEDNWLRIKVVKGDLIIIPAGIYHRFTLDTNNFIRTRRYFVGEPVWAPHNRPADEMDCRKSYIKHQSENFVQFNKV

Gene
adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Danio rerio
Length
181 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14.
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.423 kDa
Sequence
MSVFEAWYMDEESGEDQRLPHKLSPNQPVSVQQLEHIGVFHWKLNADIYENDPELQKIREEKGYSFMDIITIHPDKLPDYQNKLKMFYEEHLHLDDEIRYILEGSSYFDVRDEGDRWIRIAVSKGDLITLPAGIYHRFTVDESNYTKAMRLFVGEPVWKAYNRPADDFDIRKEYVNSLGSS

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 / race SCCL)
Length
181 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.336 kDa
Sequence
MRAYIYDEESQLSPQDEHESSQSVSKQELEKLGVLYWSIDSIDQVNSIAIQRDYKNRDQIICSPQAMGDIYQQKLDTFFEEHLHEDEEIRWVVEGSGYFDVRDQTDQRWVRIKVEKGDLLVLPPGIFHRFTVDKDNYIKAMRLFKDEPKWVALNRSTESESNPYRKAYIEQVGKAMTMGAF

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Gallus gallus
Length
180 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14.
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.674 kDa
Sequence
MVEAWYMDESQEDQRAPHRLQPNRAVSLEQLRRLGVAYRRLDADNYETDPRLKEIREAENYSWMDIVTIHKDKLPNYEEKIKTFYEEHLHLDDEIRYILDGSGYFDVRDKDDKWIRISMEKGDMITLPAGIYHRFTLDENNYVKAMRLFVGEPVWTAYNRPADDFPARKQYMKFLAEEAQ

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Bos taurus
Length
179 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14.
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.487 kDa
Sequence
MVEAWYMDEAADDPRLPHRAEPARPVGLEQLRRLGVLYWKLDADKYENDPELEKIRKERNYSWVDIITISKDKLPNYEEKIKMFFEEHLHLDEEIRYILDGSGYFDVRDQEDRWIRISMEKGDMITLPAGIYHRFTLDEKNYVKAMRLFVGDPVWTPYNRPSDHLEARTQYLEFLAQSA

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Macaca mulatta
Length
179 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14.
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.573 kDa
Sequence
MVQAWYMDDAPGDPRQPHRPDPDRPVGLEQLRRLGVLYWKLDADKYENDPELEKIRRERNYSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDKWIRIFMEKGDMITLPAGIYHRFTVDEKNYAKAMRLFVGEPVWTAYNRPADHFEARGQYMKFLAQTA

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Monodelphis domestica
Length
179 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14.
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.811 kDa
Sequence
MVEAWYMDDSEEDQRRPHRLEPERPVSLAHLQQLGVFYWKLDADKYEDDPELEKIRKERKYCWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDKWIRIFMEKGDMITLPAGIYHRFTLDETNYVKAMRLFVGEPVWTAYNRPADHFEIRGQYLQFLAQKG

Gene
Adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Mus musculus
Length
179 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (PubMed:26858196). Also down-regulates cell migration mediated by MMP14.
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.524 kDa
Sequence
MVQAWYMDESTADPRKPHRAQPDRPVSLEQLRTLGVLYWKLDADKYENDPELEKIRKMRNYSWMDIITICKDTLPNYEEKIKMFFEEHLHLDEEIRYILEGSGYFDVRDKEDKWIRISMEKGDMITLPAGIYHRFTLDEKNYVKAMRLFVGEPVWTPYNRPADHFDARVQYMSFLEGTA

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Homo sapiens
Length
179 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.498 kDa
Sequence
MVQAWYMDDAPGDPRQPHRPDPGRPVGLEQLRRLGVLYWKLDADKYENDPELEKIRRERNYSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDQWIRIFMEKGDMVTLPAGIYHRFTVDEKNYTKAMRLFVGEPVWTAYNRPADHFEARGQYVKFLAQTA

Gene
adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Xenopus laevis
Length
179 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14.
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.3 kDa
Sequence
MVQAWYMDDSAEDQRKPHRLQQDVPVSLEQLKALGVDSLSLDADRYESDPELAKIRKENNYTWMDIITIHKDTMPNYEEKLKIFYEEHLHLDDEIRYILEGSGYFDVRDQKDKWIRIFMQKGDMITLPAGIYHRFTLDENNYVKAMRLFVGDPVWTPFNRPADNCEAREKYVQFLAQTA

Gene
adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Xenopus tropicalis
Length
179 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14.
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.494 kDa
Sequence
MVQAWYMDDSTEDQRKPHHLQPEQPVSLEQLKAVGVHSFSLDADRYESDPELAKIRQENNYTWMDIITIHKDTLPNYEEKLKIFYEEHLHLDDEIRYILEGSGYFDVRDKEDRWIRIFMQKGDMITLPAGIYHRFTLDENNYVKAMRLFVGDPVWTPYNRPADNFEAREKYVQFLTQTV

Gene
Adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Rattus norvegicus
Length
179 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14 (By similarity). Induces apoptosis when overexpressed.
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.461 kDa
Sequence
MVQAWYMDESTADPRMPHRAQPDRPVGLEQLRTLGVLYWKLDADKYENDPELEQIRKTRNYSWMDIITICKDSLPNYEEKIKMFFEEHLHLDEEIRYILEGSGYFDVRDKEDKWIRISMEKGDMITLPAGIYHRFTLDEKNYVKAMRLFVGEPVWTPYNRPADHFDARVQYVKFLEGTA

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Length
179 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
20.879 kDa
Sequence
MVKVYIHDNKVDSDYRAPHNSGTELSLDELAKLGVIYKYCANEEEVNEIARQREYKNRDVVNICEGSFKSEAEFNEKLATFYQEHLHEDEEIRYCLEGAGYFDVRDASTPENWIRCLVESGDLLILPPGIYHRFTLTTSNHIKALRLFKDEPKWQAINRSNQADSLPVRKDYIALINQY

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876)
Length
178 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.008 kDa
Sequence
MVEFYFHDNKDTLENFTEDHNSGEPVSFDQLAEIGVIYKYITTQEELDALATEREYKNRDVVTLNLPAFNNDIDAYNAKMQQFYKEHYHEDEEIRYIAEGEGYFDVRDKQDRWIRAKLSPYDLLILPAGIYHRFTLTNAAKHVKAVRLFKDEPKWEAINRDTGKNTEARELYAKTIAV

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Candida albicans (strain WO-1)
Length
178 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
21.008 kDa
Sequence
MVEFYFHDNKDTLENFTEDHNSGEPVSFDQLAEIGVIYKYITTQEELDALATEREYKNRDVVTLNLPAFNNDIDAYNAKMQQFYKEHYHEDEEIRYIAEGEGYFDVRDKQDRWIRAKLSPYDLLILPAGIYHRFTLTNAAKHVKAVRLFKDEPKWEAINRDTGKNTEARELYAKTIAV

Gene
adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Length
178 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
20.974 kDa
Sequence
MKAYFYDNLPGDQRLPHDSGKEVTVAELEKVGVLYFRFPDVEGVNTLAAERGYKNRDEIIVSPEKMGAIYETKVRQFFDEHLHEDEEIRYIRDGAGYFDVRNEGDEWIRIKLVKDDLIILPAGIYHRFTTDDTNYIQAMRLFKEEPKWTPLNRTEGLDENPYRQEYVTQFLKAQAEQA

Gene
adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
178 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
20.886 kDa
Sequence
MKAYWYDNKPGDQREPHDSGRPVSEDYLASLGVIYRHFPELSDVDALAKERGYKNRDEITVSPATMGEAYEDKVKMFFAEHLHEDEEIRYIRDGEGYFDVRGKEDEWVRIRLVKDDLIILPAGIYHRFTTDNKNYIKAMRLFQEEPKWTPLNRAPELDENQHRKSYLEGLTATSIAAN

Gene
adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Length
178 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
20.936 kDa
Sequence
MRAYIFQDEGDQRKPNDSKIEVSAEDLEAAKVSYRHHDGDLHTFADGLMKEYGFKNRDEVVVSRKGLGDRYDNMVKKFFEEHLHEDEEIRLILDGNGYFDVRSVDDRWVRIFVEKGDLIILPPGIYHRFTTTTDDYIHAMRLFHENPKWIALSRTDSTSEELDARKSYLNSIKKSVYV

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
Length
176 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
20.538 kDa
Sequence
MKAYWYDNIPGDQRLPHDSGRTVDASYLATIGVLYRHCPAISAVDDLARDRGYKNRDEIIISPEKMGDVYEDKVRMFFNEHLHEDEEIRYIVDGEGFFDVRSKDDEWVRIRLGKGDLIVLPAGIYHRFTTDENNYVKAMRLFQDEPKWTPLNRAPELDANQHRKTYVESHISSSTA

Gene
adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
176 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
20.848 kDa
Sequence
MKAYWYDNKPGDQREPHDSGRPVTVDYLASIGVQYYHFPSLESVNELAKERGYKNRDEIVVSPQAMGDVYEEKVKMFFNEHLHEDEEIRYIRDGEGYFDVRGQEDEWVRIKLAKDDLIILPAGIYHRFTTDDKNYVKAMRLFQEEPKWTPLNRGPDVDENSHRQSYLRTIQNKTVA

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI)
Length
176 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
20.629 kDa
Sequence
MRAYFYDGLPGDQRLPHDSGKPVNVDDLLAIGVYYYHLPELESVDNLARDRGYKNRDEITVSPKTMGDVYESKVKMFFAEHLHEDEEIRYIRGGRGYFDVRSKDDDWVRVLLEKDDLLILPAGIYHRFTTDETNYVHAMRLFKEDPKWTALNRGPEVDNNGHRQEYVKTFLAEPAQ

Gene
adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)
Length
176 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
20.988 kDa
Sequence
MRAYWFDNKEGDQRELHDSGRDVDPEYLEKLGVLYYHFADEKDVDKLASDRSYKNRDVITVSPQKMGDVYEEKVKMFFNEHLHEDEEIRYIRDGAGFFDVRSEGDEWVRIRLEKDDLIILPAGIYHRFTTDDKNYIQAMRLFKEEPKWTPLNRGPEVDANPYRKEYLQTVPAIASQ

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173)
Length
175 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
20.746 kDa
Sequence
MRAYWFDNLEGDQRQPHDSGRAVDPAYLSKLGVLYHHISSQSEVDELAKARDYKNRDEITVSPEKMGDIYEEKVKSFFHEHLHEDEEIRYILDGAGYFDVRSEGDDWVRIWLEKGDLIILPSGIYHRFTTDEQNYTKAMRLFKDEPKWTPLNRGEETDENQFRQEYLKLRQGLAA

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Tuber melanosporum (strain Mel28)
Length
173 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
19.989 kDa
Sequence
MKVYEYDNSTEDQREDHDSGAVVSEAALNEIGVLAYHFDSVDDVNALAAERGYKNRDEVTISPSALGDIYEDKVKAFFHEHLHEDEEIRYILDGEGFFDVRSKDDSWVRIRLSKGDLIILPAGIYHRFTTDKNNYIKAMRLFQEDPKWTPLNRDPLVDENAYRKAYINSLPLA

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
173 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
20.356 kDa
Sequence
MKFYYHDNDSSVDQCAPHDSGEPVTAEQLEKIGVLAFHYPDVEDVNRLAKERKYTNRDEVTITPEAMGGQENYEKKLKVFYEEHLHEDEEIRYILDGEGYFDVRDKDDRWIRAQLNAGDLLILPSGIYHRFTLSEKNYVHTMRLFQAEPKWVALPRPVDNNPYRQEYVKAISA

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)
Length
158 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
18.219 kDa
Sequence
MKAYMYDNQPGDQRLPHDSGRAISTEALGKLGVLYFHFANIADVDRLAADRGYKNRDEITVSPEKMGGMYEDKVKMFFNEHLHEDEEIRYIKGGQGFFDVRSKDDNWVRVRLEKDDLLILPAGIYHRFTTDEANVPVPRIVRTCHEALQGRAQMDAIE

Gene
adi1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Dictyostelium discoideum
Length
147 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
17.815 kDa
Sequence
MKSYFYDNESDVISLDYLKEHNVLYFPMDREKENYKEPLETLCKERGYKNRDEVKLSKETPGLEDKLKIFFEEHLHDDEEIRFILDGCGFFDIRDKNDKWVKIKEKKGDLIIVPANMYHRFALDESRNIHAMRLFTDAPKWVPINRY

Gene
ADI1
Protein
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
Organism
Polysphondylium pallidum (strain ATCC 26659 / Pp 5 / PN500)
Length
146 amino acids
Function
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Similarity
Belongs to the acireductone dioxygenase (ARD) family.
Mass
17.568 kDa
Sequence
MKSYYFESNEPVSVQQLNNINVLYYPMPMPDYQEKLDQICQERGYKNRDEVKLNENTENLDAKLKIFFEEHLHDDEEIRFILEGSGFFDVRDANDQWIRIRVEKGDLIIVPANMYHRFTLTETKQIHACRLFTDAPKWVPINRHQQ

Gene
ADI1
Protein
Ferredoxin-1, chloroplastic
Organism
Oryza sativa subsp. indica
Length
139 amino acids
Function
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Similarity
Belongs to the 2Fe2S plant-type ferredoxin family.
Mass
14.951 kDa
Sequence
MAATALSSQVRLPMSLRVATAPAPARVSVLPASNKLGDRLRMQATYNVKLITPDGEVELQVPDDVYILDQAEEEGIDLPYSCRAGSCSSCAGKVVSGEIDQSDQSFLDDDQVAAGWVLTCHAYPKSDVVIETHKEDDLI

Gene
ADI1
Protein
Ferredoxin-1, chloroplastic
Organism
Oryza sativa subsp. japonica
Length
139 amino acids
Function
Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.
Similarity
Belongs to the 2Fe2S plant-type ferredoxin family.
Mass
14.951 kDa
Sequence
MAATALSSQVRLPMSLRVATAPAPARVSVLPASNKLGDRLRMQATYNVKLITPDGEVELQVPDDVYILDQAEEEGIDLPYSCRAGSCSSCAGKVVSGEIDQSDQSFLDDDQVAAGWVLTCHAYPKSDVVIETHKEDDLI