ADH2

Aldehyde-alcohol dehydrogenase 2

870 amino acids

This enzyme has two NAD(+)-dependent activities: ADH and ACDH. May be a critical enzyme in the fermentative pathway.

In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.

95.659 kDa

MSTQQTMTVDEHINQLVRKAQVALKEYLKPEYTQEKIDYIVKKASVAALDQHCALAAAAVEETGRGIFEDKATKNIFACEHVTHEMRHAKTVGIINVDPLYGITEIAEPVGVVCGVTPVTNPTSTAIFKSLISIKTRNPIVFSFHPSALKCSIMAAKIVRDAAIAAGAPENCIQWIEFGGIEASNKLMNHPGVATILATGGNAMVKAAYSSGKPALGVGAGNVPTYIEKTCNIKQAANDVVMSKSFDNGMICASEQAAIIDKEIYDQVVEEMKTLGAYFINEEEKAKLEKFMFGVNAYSADVNNARLNPKCPGMSPQWFAEQVGIKVPEDCNIICAVCKEVGPNEPLTREKLSPVLAILKAENTQDGIDKAEAMVEFNGRGHSAAIHSNDKAVVEKYALTMKACRILHNTPSSQGGIGSIYNYIWPSFTLGCGSYGGNSVSANVTYHNLLNIKRLADRRNNLQWFRVPPKIFFEPHSIRYLAELKELSKIFIVSDRMMYKLGYVDRVMDVLKRRSNEVEIEIFIDVEPDPSIQTVQKGLAVMNTFGPDNIIAIGGGSAMDAAKIMWLLYEHPEADFFAMKQKFIDLRKRAFKFPTMGKKARLICIPTTSGTGSEVTPFAVISDHETGKKYPLADYSLTPSVAIVDPMFTMSLPKRAIADTGLDVLVHATEAYVSVMANEYTDGLAREAVKLVFENLLKSYNGDLEAREKMHNAATIAGMAFASAFLGMDHSMAHKVGAAFHLPHGRCVAVLLPHVIRYNGQKPRKLAMWPKYNFYKADQRYMELAQMVGLKCNTPAEGVEAFAKACEELMKATETITGFKKANIDEAAWMSKVPEMALLAFEDQCSPANPRVPMVKDMEKILKAAYYPIA

adh2

Long-chain-alcohol dehydrogenase 2

387 amino acids

Long-chain alkyl alcohol dehydrogenase that can oxidize a broad range of alkyl alcohols from methanol to 1-triacontanol (C1 to C30) as well as 1,3-propanediol and acetaldehyde. Oxidizes isopropyl alcohol, isoamylol, acetone, octanal and decanal. The best substrate is 1-octanol.

Belongs to the iron-containing alcohol dehydrogenase family.

42.804 kDa

MQNFTFRNPTKLIFGRGQIEQLKEEVPKYGKKVLLVYGGGSIKRNGLYDEVMSLLTDIGAEVVELPGVEPNPRLSTVKKGVDICRREGIEFLLAVGGGSVIDCTKAIAAGAKFDGDPWEFITKKATVTEALPFGTVLTLAATGSEMNAGSVITNWETKEKYGWGSPVTFPQFSILDPTYTMTVPKDHTVYGIVDMMSHVFEQYFHHTPNTPLQDRMCEAVLKTVIEAAPKLVDDLENYELRETIMYSGTIALNGFLQMGVRGDWATHDIEHAVSAVYDIPHAGGLAILFPNWMKHVLDENVSRFAQLAVRVFDVDPTGKTERDVALEGIERLRAFWSSLGAPSRLADYGIGEENLELMADKAMAFGEFGRFKTLNRDDVLAILRASL

ADH2

Alcohol dehydrogenase 2

380 amino acids

Belongs to the zinc-containing alcohol dehydrogenase family.

41.04 kDa

MSTTVGQVIRCKAAVAWEAGKPLVMEEVDVAPPQKMEVRLKILYTSLCHTDVYFWEAKGQNPVFPRILGHEAAGIVESVGEGVTDLAPGDHVLPVFTGECKDCAHCKSEESNMCSLLRINTDRGVMLNDGKSRFSINGNPIYHFVGTSTFSEYTVVHVGCVAKINPLAPLDKVCVLSCGISTGLGASLNVAKPTKGSSVAIFGLGAVGLAAAEGARIAGASRIIGVDLNASRFEQAKKFGVTEFVNPKDYSKPVQEVIAEMTDGGVDRSVECTGHIDAMISAFECVHDGWGVAVLVGVPHKEAVFKTHPLNFLNERTLKGTFFGNYKPRSDIPCVVEKYMNKELELEKFITHTLPFAEINKAFDLMLKGEGLRCIITMAD

ADH2

Alcohol dehydrogenase 2

380 amino acids

Belongs to the zinc-containing alcohol dehydrogenase family.

41.144 kDa

MSTTTGQVIRCKAAVAWEAGKPLVMEEVDVAPPQKMEVRLKILYTSLCHTDVYFWEAKGQNPVFPRILGHEAAGIVESVGEGVTELAPGDHVLPVFTGECKDCAHCKSEESNMCSLLRINTDRGVMINDGQSRFSINGKPIYHFVGTSTFSEYTVVHVGCVAKINPLAPLDKVCVLSCGISTGLGATLNVAKPTKGSSVAIFGLGAVGLAAAEGARIAGASRIIGVDLNASRFEQAKKFGVTEFVNPKDYSKPVQEVIAEMTDGGVDRSVECTGHIDAMISAFECVHDGWGVAVLVGVPHKEAVFKTHPMNFLNERTLKGTFFGNYKPRSDIPSVVEKYMNKELELEKFITHTLPFAEINKAFDLMLKGEGLRCIITMED

ADH2

Alcohol dehydrogenase 2

379 amino acids

Belongs to the zinc-containing alcohol dehydrogenase family.

41.054 kDa

MATAGKVIKCRAAVTWEAGKPLSIEEVEVAPPQAMEVRIKILYTALCHTDVYFWEAKGQTPVFPRILGHEAGGIVESVGEGVTDVAPGDHVLPVFTGECKECAHCKSEESNMCDLLRINVDRGVMIGDGKSRFTISGQPIFHFVGTSTFSEYTVIHVGCLAKINPEAPLDKVCILSCGISTGLGATLNVAKPAKGSTVAIFGLGAVGLAAMEGARLAGASRIIGVDINPAKYEQAKKFGCTEFVNPKDHDKPVQEVLIELTNGGVDRSVECTGNVNAMISAFECVHDGWGVAVLVGVPHKDDQFKTHPMNFLSEKTLKGTFFGNYKPRTDLPNVVEMYMKKELELEKFITHSVPFSEINTAFDLMLKGESLRCIMRMED

ADH2

Alcohol dehydrogenase 2

379 amino acids

Belongs to the zinc-containing alcohol dehydrogenase family.

41.207 kDa

MATAGKVIKCKAAVAWEAGKPLSIEEVEVAPPQAMEVRVKILYTALCHTDVYFWEAKGQTPVFPRILGHEAGGIVESVGEGVTELAPGDHVLPVFTGECKECDHCKSEESNMCDLLRINVDRGVMIGDGKSRFTIKGKPIFHFVGTSTFSEYTVIHVGCLAKINPEAPLDKVCILSCGFSTGFGATVNVAKPKKGQTVAIFGLGAVGLAAMEGARLSGASRIIGVDLNPAKFEQAKKFGCTDFVNPKDHSKPVHEVLIEMTNGGLDRAVECTGNINAMISCFECVHDGWGVAVLVGVPTKDDVFKTHPMNFLNEKTLKGTFFGNYKPRTDLPNVVELYMKKELELEKFITHSVPFSEINTAFDLMLKGESLRCVMRMDE

ADH2

Alcohol dehydrogenase 2

379 amino acids

Belongs to the zinc-containing alcohol dehydrogenase family.

41.207 kDa

MATAGKVIKCKAAVAWEAGKPLSIEEVEVAPPQAMEVRVKILYTALCHTDVYFWEAKGQTPVFPRILGHEAGGIVESVGEGVTELAPGDHVLPVFTGECKECDHCKSEESNMCDLLRINVDRGVMIGDGKSRFTIKGKPIFHFVGTSTFSEYTVIHVGCLAKINPEAPLDKVCILSCGFSTGFGATVNVAKPKKGQTVAIFGLGAVGLAAMEGARLSGASRIIGVDLNPAKFEQAKKFGCTDFVNPKDHSKPVHEVLIEMTNGGLDRAVECTGNINAMISCFECVHDGWGVAVLVGVPTKDDVFKTHPMNFLNEKTLKGTFFGNYKPRTDLPNVVELYMKKELELEKFITHSVPFSEINTAFDLMLKGESLRCVMRMDE

ADH2

Alcohol dehydrogenase class-3

379 amino acids

Plays a central role in formaldehyde detoxification.

Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.

40.699 kDa

MATQGQVITCKAAVAYEPNKPLVIEDVQVAPPQAGEVRIKILYTALCHTDAYTWSGKDPEGLFPCILGHEAAGIVESVGEGVTEVQAGDHVIPCYQAECRECKFCKSGKTNLCGKVRSATGVGIMMNDRKSRFSVNGKPIYHFMGTSTFSQYTVVHDVSVAKIDPTAPLDKVCLLGCGVPTGLGAVWNTAKVEPGSNVAIFGLGTVGLAVAEGAKTAGASRIIGIDIDSKKYETAKKFGVNEFVNPKDHDKPIQEVIVDLTDGGVDYSFECIGNVSVMRAALECCHKGWGTSVIVGVAASGQEISTRPFQLVTGRVWKGTAFGGFKSRTQVPWLVEKYMNKEIKVDEYITHNLTLGEINKAFDLLHEGTCLRCVLDTSK

ADH2

Alcohol dehydrogenase 2

373 amino acids

Belongs to the zinc-containing alcohol dehydrogenase family.

40.512 kDa

MATAGKVIKCKAAVAWEAGKPLSMEEVEDAPPQAMEVRDKILYTALCHTDVYFWEANGQTPVFPRILGHEAGGIVESVGEGVTELVPGDHVLPVFTGECKECAHCMSEESNLCDLLRINVDRGVMIDDGQSRFTIDGKPIFHFLGTSTFSEYTVIHVGCVAKIDPEAPLDKVCLLSCGISTGLGATLNVTKPKKGMTVAIFGLGAVGLAAMEGARMSGASRIIGVDLNPAKHEQAKKFGCTDFVNPKDHTKPVQEVIVEMTDGGVNRAVECTGNADAMISAFECVHDGWGVAHKEAVFKTHPMNFLNERTLRGTFFGNYKPRTGLPGVVDMYMRKELELDKFITHSLPFSQINTAFDLMLRGEGLRCVIRSEE

ADH2

Alcohol dehydrogenase 2

351 amino acids

Versatile oxidoreductase that catalyzes the oxidation and reduction of a broad range of substrates. Preferentially oxidizes secondary alcohols. Has highest activity for racemic 2-octanol. Is also an efficient reductase for selected substrates. Substrate selectivity was found for medium chain lipophilic ketones. Has highest activities for 2-octanone, 2-nonanone and 2-decanone. The enzyme is (S)-selective in the reduction direction and produces exclusively the (S)-enantiomer.

Belongs to the zinc-containing alcohol dehydrogenase family.

37.315 kDa

MSAPVIPKTQKGVIFETSGGPLMYKDIPVPVPADDEILVNVKFSGVCHTDLHAWKGDWPLDTKLPLVGGHEGAGVVVAKGKNVDTFEIGDYAGIKWINKACYTCEFCQVAAEPNCPNATMSGYTHDGSFQQYATANAVQAAHIPKNCDLAEIAPILCAGITVYKALKTAAILAGQWVAVTGAGGGLGTLAVQYAKAMGYRVLAIDTGADKEKMCKDLGAEVFIDFAKTKDLVKDVQEATKGGPHAVINVSVSEFAVNQSIEYVRTLGTVVLVGLPAGAVCKSPIFQQVARSIQIKGSYVGNRADSQEAIEFFSRGLVKSPIIIIGLSELEKVYKLMEEGKIAGRYVLDTSK

ADH2

Alcohol dehydrogenase 2

348 amino acids

Belongs to the zinc-containing alcohol dehydrogenase family.

37.098 kDa

MSIPETQKGVIFYENGGELQYKDIPVPKPKANELLINVKYSGVCHTDLHAWKGDWPLPTKLPLVGGHEGAGVVVAMGENVKGWNIGDFAGIKWLNGSCMSCEYCELSNESNCPDADLSGYTHDGSFQQYATADAVQAARIPKGTDLAEVAPILCAGVTVYKALKSADLKAGDWVAISGACGGLGSLAIQYAKAMGYRVLGIDTGAEKAKLFKELGGEYFVDYAVSKDLIKEIVDATNGGAHGVINVSVSEFAIEQSTNYVRSNGTVVLVGLPRDAKCKSDVFTQVVKSVSIVGSYVGNRADTREALDFFARGLVHAPIKIVGLSELADVYDKMVKGEIVGRYVVDTSK

ADH2

Alcohol dehydrogenase 2

348 amino acids

Belongs to the zinc-containing alcohol dehydrogenase family.

36.968 kDa

MSIPTTQKGVIFYENGGQLYYKDIPVPKPKSNELLINVKYSGVCHTDLHAWKGDWPLDTKLPLVGGHEGAGVVVAMGDNVKGWKIGDLAGIKWLNGSCMNCEECELSNESNCPDADLSGYTHDGSFQQYATADAVQAAHIPAGTDLAQVAPILCAGVTVYKALKTAEMKAGDWVAISGAAGGLGSLAVQYAKAMGFRVLGIDGGEGKEELFKSLGGEVFIDFTKSKDIVGEVIKATNGGAHGVINVSVSEKAIESSIEYCRSNGTVVLVGLPKDAKCKSDVFNQVVKSIHIVGSYVGNRADTREALDFFCRGLVNAPIKVVGLSTLPEIYEKMEQGKVLGRYVVDTSK

ADH2

Alcohol dehydrogenase 2

348 amino acids

Converts ethanol to acetaldehyde.

Belongs to the zinc-containing alcohol dehydrogenase family.

36.565 kDa

MSIPTTQKAVIFETNGGPLLYKDIPVPKPKPNELLINVKYSGVCHTDLHAWKGDWPLDTKLPLVGGHEGAGVVVALGENVTGWEIGDYAGIKWINGSCLQCEYCVTAHESNCPDADLSGYTHDGSFQQYATADAIQAARIPKGTDLALIAPILCAGITVYKALKTAQLQAGQWVAVSGAAGGLGSLAIQYAKAMGYRVVGIDGGADKGEFAKSLGAEVFVDFLSSKDVVADVLKATNGGAHGVINVSVSERAMQQSVDYVRPTGTVVLVGLPAGAKVSASVFSSVVRTIQIKGSYVGNRADSAEAIDFFTRGLIKCPIKIVGLSELASVYELMEQGKILGRYVVDTSK

ADH2

Alcohol dehydrogenase 2

348 amino acids

This isozyme preferentially catalyzes the conversion of ethanol to acetaldehyde. Acts on a variety of primary unbranched aliphatic alcohols.

Belongs to the zinc-containing alcohol dehydrogenase family.

36.732 kDa

MSIPETQKAIIFYESNGKLEHKDIPVPKPKPNELLINVKYSGVCHTDLHAWHGDWPLPTKLPLVGGHEGAGVVVGMGENVKGWKIGDYAGIKWLNGSCMACEYCELGNESNCPHADLSGYTHDGSFQEYATADAVQAAHIPQGTDLAEVAPILCAGITVYKALKSANLRAGHWAAISGAAGGLGSLAVQYAKAMGYRVLGIDGGPGKEELFTSLGGEVFIDFTKEKDIVSAVVKATNGGAHGIINVSVSEAAIEASTRYCRANGTVVLVGLPAGAKCSSDVFNHVVKSISIVGSYVGNRADTREALDFFARGLVKSPIKVVGLSSLPEIYEKMEKGQIAGRYVVDTSK

ADH2

Alcohol dehydrogenase 2

348 amino acids

Belongs to the zinc-containing alcohol dehydrogenase family.

36.807 kDa

MSVPTTQKAVIFETNGGKLEYKDIPVPKPKANELLINVKYSGVCHTDLHAWKGDWPLATKLPLVGGHEGAGVVVALGENVKGWKVGDYAGVKWLNGSCLNCEYCQSGAEPNCAEADLSGYTHDGSFQQYATADAVQAARIPAGTDLANVAPILCAGVTVYKALKTAELEAGQWVAISGAAGGLGSLAVQYAKAMGYRVLAIDGGEDKGEFVKSLGAETFIDFTKEKDVVEAVKKATNGGPHGVINVSVSERAIGQSTEYVRTLGKVVLVGLPAGAKISTPVFDAVIKTIQIKGSYVGNRKDTAEAVDFFTRGLIKCPIKIVGLSELPEVYKLMEEGKILGRYVLDNDK

ADH2

Alcohol dehydrogenase 2

258 amino acids

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.936 kDa

MGLSGKNVIFVGGLGFIGYEACKQLMAKNMASFFVFDVLDKPENIKALQALNPKTKVYYTKFDITSKQSIKSALADVVAKVKYIDALINGAGILTDPNVELTMNINLIGLINTTLEGLPLMDKNKQGRGGVIVNIASVLGLEPCPPAAVYCASKFGVMGFSRSIGDPYYYNITGVAVVTFCPGLTETPLKNNIGSKYTFEYSKKISEELNSTKTQKPEVCGAHLAQVVESHENGGIYISNQGTLAKVTPTVYWQPTYH

ADH2

Alcohol dehydrogenase 2

258 amino acids

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

28.01 kDa

MGLSGKNVIFVGGLGFIGYEACKQLMAKNMASFFVFDVLDKPEDIKALQALNPKTKVYYTKFDITSKQSIKSALADVVSKVKYIDALINGAGILTDLNVELTMNINLIGLINTTLEALPLMDKNKQGRGGVIVNIASVLGLEPCPPAAVYCASKFGVMGFSRSIGDPYYYNITGVAVVTFCPGLTETPLKNNIGSKYTFEYSKKISEELNNTKTQKPEVCGAHLAQVVESHENGGIYISNQGTLAKVTPTVYWQPTYH

ADH2

Alcohol dehydrogenase 2

258 amino acids

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.968 kDa

MGLSGKNVIFVGGLGFIGYEACKQLMAKNMASFFVFDVLDKPEDIKALQALNPKTKVYYTKFDITSKQSIKSALADVVSKVKYIDALINGAGILTDLNVELTMNINLIGLINTTLEGLPLMDKNKQGRGGVIVNIASVLGLEPCPPAAAYCASKFGVMGFSRSIGDPYYYNITGVAVVTFCPGLTETPLKNNIGSKYTFEYSKKISEELNNTKTQKPEVCGAHLAQVVESHENGGIYISNQGTLAKVTPTVYWQPTYH

Adh2

Alcohol dehydrogenase 2

254 amino acids

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.578 kDa

MAIANKNIIFVAGLGGIGFDTSREIVKSGPKNLVILDRIENPAAIAELKALNPKVTVTFYPYDVTVSVAETTKLLKTIFDKLKTVDLLINGAGILDDYQIERTIAVNFTGTVNTTTAIMSFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLARLAPITGVTAYSINPGITKTTLVHKFNSWLDVEPRVAELLLEHPTQTTLQCAQNFVKAIEANQNGAIWKLDLGTLEAIEWTKHWDSHI

Adh2

Alcohol dehydrogenase 2

254 amino acids

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.519 kDa

MAIANKNIIFVAGLGGIGFDTSREIVKSGPKNLVILDRIENPAAIAELKALNPKVTVTFYPYDVTVPVAETTKLLKTIFDKLKTVDLLINGAGILDDYQIERTIAVNFTGTVNTTTAIMAFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLAKLAPITGVTAYSINPGITKTTLVHKFNSWLDVEPRVAELLLEHPTQTTLQCAQNFVKAIEANQNGAIWKLDLGRLEAIEWTKHWDSGI

Adh2

Alcohol dehydrogenase 2

254 amino acids

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.415 kDa

MAIANKNIIFVAGLGGIGLDTSREIVKSGPKNLVILDRIDNPAAIAELKAINPKVTITFYPYDVTVSVAESTKLLKVIFDKLKTVDLLINGAGILDDYQIERTIAVNFAGTVNTTTAIMAFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLAKLAPITGVTAYSINPGITKTTLVHKFNSWLDVEPRVAELLLEHPTQTTLQCAQNFVKAIEANKNGAIWKLDLGRLDAIEWTKHWDSGI

Adh2

Alcohol dehydrogenase 2

254 amino acids

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.55 kDa

MAIANKNIIFVAGLGGIGLDTSREIVKSGPKNLVILDRIDNPTAIAELKAINPKVTVTFYPYDVTVPVAETTKLLKTIFAQLKTVDLLINGAGILDDHQIERTIAVNFTGTVNTTTAIMEFWDKRKGGPGGVIANICSVTGFNAIYQVPVYSASKAAALSFTNSLARLAPITGVTAYSINPGITRTPLVHKFNSWLDVEPRVGELLLEHPTQTTLECAQNFVKAIEANKNGAIWQLDLGQLIAVEWTKHWDSHI

Adh2

Alcohol dehydrogenase 2

254 amino acids

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.605 kDa

MAIANKNIIFVAGLGGIGFDTSREIVKRGPKNLVILDRIENPAAIAELKALNPKVTVTFYPYDVTVSVAETTKLLKTIFDKLKTVDLLINGAGILDDHQIERTIAVNFTGTVNTITAIMSFWDKRKGGPGGVIANVCSVTGFNAIYQVPVYSASKAAALSFTNSLARLAPITGVTAYSINPGITKTTLVHKFNSWLDVEPRVAELLLEHPTQTTLQCAQNFVKAIEANQNGAIWKVDLGTLEAIEWTKHWDSHI

Adh2

Alcohol dehydrogenase 2

254 amino acids

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.592 kDa

MVIANKNIIFVAGLGGIGFDTSREIVKSGPKNLVILDRIENPAAIAELKALNPKVTVTFYPYDVTVSVAETTKLLKTIFDKLKTVDLLINGAGILDDYQIERTIAVNFTGTVNTTTAIMSFWDKRKGGPGGIIANICSVTGFNAIYQVPVYSASKAAALSFTNSLAKLAPITGVTAYSINPGITKTTLVHKFNSWLDVEPRVAELLLEHPTQTTLQCAQNFVKAIEANQNGAIWKLDLGTLEAIEWTKHWDSHI

Adh2

Alcohol dehydrogenase 2

254 amino acids

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

27.614 kDa

MVIANKNIIFVAGLGGIGFDTSREIVKSGPKNLVILDRIENPAAIAELKALNPKVTVTFYPYDVTVSVAETTKLLKTIFDKLKTVDILINGAGILDDYQIERTIAVNFTGTVNTTTAIMSFWDKRKGGPGGIIANICSVTGFNAIYQVPVYSASKAAALSFTNSLAKLAPITGVTAYSINPGITVTPLVHKFNSWLDVEPRVAELLLEHPTQTRLQCAQNFVKAIEANQNGAIWKLDLGTLEAIEWTKHWDSHI