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ADCYAP1

Gene
ADCYAP1
Protein
Pituitary adenylate cyclase-activating polypeptide
Organism
Bos taurus
Length
176 amino acids
Function
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Similarity
Belongs to the glucagon family.
Mass
19.464 kDa
Sequence
MTMCSGARLALLVYGILMHSSVYGSPAASGLRFPGIRPENEVYDEDGNPQQDFYDSESLGVGSPASALRDAYALYYPAEERDVAHGILNKAYRKVLDQPSARRSPADAHGQGLGWDPGGSADDDSEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIPYL

Gene
ADCYAP1
Protein
Pituitary adenylate cyclase-activating polypeptide
Organism
Homo sapiens
Length
176 amino acids
Function
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Similarity
Belongs to the glucagon family.
Mass
18.835 kDa
Sequence
MTMCSGARLALLVYGIIMHSSVYSSPAAAGLRFPGIRPEEEAYGEDGNPLPDFDGSEPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL

Gene
ADCYAP1
Protein
Pituitary adenylate cyclase-activating polypeptide
Organism
Sus scrofa
Length
176 amino acids
Function
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Similarity
Belongs to the glucagon family.
Mass
19.523 kDa
Sequence
MTMCSGARLALLVYGIIMHSSVYCSPAAAGLRFPGIRPEDEAYDEDGNPLQDFYDSDPPGVGGPASTLRDAYALYYPAEERDVAHGILNKAYRKVLDQLSARKYLQTLMAKSVGGNLDGGAEDDSEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL

Gene
ADCYAP1
Protein
Pituitary adenylate cyclase-activating polypeptide
Organism
Ovis aries
Length
176 amino acids
Function
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Similarity
Belongs to the glucagon family.
Mass
19.459 kDa
Sequence
MTMCSGARLALLVYGILMHSSVYGSPAASGLRFPGIRPENEAYDEDGNPQQDFYDSEPPGVGSPASALRDAYALYYPAEERDVAHGILDKAYRKVLDQLSARRYLQTLMAKGLGGTPGGGADDDSEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIPYL

Gene
ADCYAP1
Protein
Glucagon family neuropeptides
Organism
Gallus gallus
Length
175 amino acids
Function
PACAP plays pivotal roles as a neurotransmitter and/or a neuromodulator.
Similarity
Belongs to the glucagon family.
Mass
19.561 kDa
Sequence
MSGNVYKTLLTLLVYGLIMHCNVYCSPDRWTPVPGAKLEEEVYDEDGNTLQDFALRAGAPGGGGPRPRWGRCTALYYPPGKRHADGIFSKAYRKLLGQLSARNYLHSLMAKRVGGASSGLGDEAEPLSKRHIDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRVAYL

Gene
Adcyap1
Protein
Pituitary adenylate cyclase-activating polypeptide
Organism
Mus musculus
Length
175 amino acids
Function
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (PubMed:23913443).
Similarity
Belongs to the glucagon family.
Mass
19.381 kDa
Sequence
MTMCSGARLALLVYGIIMHSSVSCSPAAGLSFPGIRPEDEAYDQDGNPLQDFYDWDPPGVGSPASALRDAYALYYPADRRDVAHEILNEAYRKVLDQLSARKYLQSVVARGAGENLGGSAVDDPAPLTKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL

Gene
Adcyap1
Protein
Pituitary adenylate cyclase-activating polypeptide
Organism
Rattus norvegicus
Length
175 amino acids
Function
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (PubMed:18198219). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
Similarity
Belongs to the glucagon family.
Mass
19.557 kDa
Sequence
MTMCSGARLALLVYGIIMHNSVSCSPAAGLSFPGIRPEEEAYDQDGNPLQDFYDWDPPGAGSPASALRDAYALYYPADRRDVAHEILNEAYRKVLDQLSARKYLQSMVARGMGENLAAAAVDDRAPLTKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL

Gene
adcyap1
Protein
Glucagon family neuropeptides
Organism
Pelophylax ridibundus
Length
171 amino acids
Function
PACAP plays pivotal roles as a neurotransmitter and/or a neuromodulator. Stimulates adenylate cyclase in pituitary cells.
Similarity
Belongs to the glucagon family.
Mass
19.68 kDa
Sequence
MYRKALLVWLLVYGIMRCTVHSSPTALKYPALRLEDEVYDEDGNTLPDFAFDNNPIGIGNPASVFDDMYSFYYPAEKRHADDLLNKAYRNLLGQLSARKYLHTLMAKHLGAVSSSLEDDSEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRIKNKGRRVAYL

Gene
Adcyap1
Protein
Pituitary adenylate cyclase-activating polypeptide
Organism
Heloderma suspectum
Length
56 amino acids
Function
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells (By similarity). Promotes neuron projection development (By similarity).
Similarity
Belongs to the glucagon family.
Mass
6.629 kDa
Fragment
multiple
Sequence
IFNKAYRKVLGQLSARKYLHSLMHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQ