ADCS

Aminodeoxychorismate synthase, chloroplastic

919 amino acids

Bifunctional enzyme that catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. In the first step, a glutamine amidotransferase generates ammonia that is channelled between the binding sites of glutamine and chorismate and used along with chorismate in the second step, catalyzed by aminodeoxychorismate synthase, to produce ADC. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis. Does not possess ADC lyase activity.

In the C-terminal section; belongs to the anthranilate synthase component I family.

102.92 kDa

MNMNFSFCSTSSELSYPSENVLRFSVASRLFSPKWKKSFISLPCRSKTTRKVLASSRYVPGKLEDLSVVKKSLPRREPVEKLGFVRTLLIDNYDSYTFNIYQALSTINGVPPVVIRNDEWTWEEAYHYLYEDVAFDNIVISPGPGSPMCPADIGICLRLLLECRDIPILGVCLGHQALGYVHGAHVVHAPEPVHGRLSGIEHDGNILFSDIPSGRNSDFKVVRYHSLIIDKESLPKELVPIAWTIYDDTGSFSEKNSCVPVNNTGSPLGNGSVIPVSEKLENRSHWPSSHVNGKQDRHILMGIMHSSFPHYGLQFHPESIATTYGSQLFKNFKDITVNYWSRCKSTSLRRRNINDTANMQVPDATQLLKELSRTRCTGNGSSYFGNPKSLFSAKTNGVDVFDMVDSSYPKPHTKLLRLKWKKHERLAHKVGGVRNIFMELFGKNRGNDTFWLDTSSSDKARGRFSFMGGKGGSLWKQLTFSLSDQSEVTSKHAGHLLIEDSQSSTEKQFLEEGFLDFLRKELSSISYDEKDFEELPFDFCGGYVGCIGYDIKVECGMPINRHKSNAPDACFFFADNVVAIDHQLDDVYILSLYEEGTAETSFLNDTEEKLISLMGLSTRKLEDQTLPVIDSSQSKTSFVPDKSREQYINDVQSCMKYIKDGESYELCLTTQNRRKIGNADPLGLYLHLRERNPAPYAAFLNFSNANLSLCSSSPERFLKLDRNGMLEAKPIKGTIARGSTPEEDEFLKLQLKLSEKNQAENLMIVDLLRNDLGRVCEPGSVHVPNLMDVESYTTVHTMVSTIRGLKKTDISPVECVRAAFPGGSMTGAPKLRSVEILDSLENCSRGLYSGSIGYFSYNGTFDLNIVIRTVIIHEDEASIGAGGAIVALSSPEDEFEEMILKTRAPANAVMEFCSDQRRQ

ADCS

Aminodeoxychorismate synthase, chloroplastic

902 amino acids

Bifunctional enzyme that catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. In the first step, a glutamine amidotransferase generates ammonia that is channelled between the binding sites of glutamine and chorismate and used along with chorismate in the second step, catalyzed by aminodeoxychorismate synthase, to produce ADC. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis. Does not possess ADC lyase activity.

In the C-terminal section; belongs to the anthranilate synthase component I family.

101.553 kDa

MNSAMSSSSSFMVASSCCQNLQTRKYFLLAPEPFEKIGMIDALQKYNRKERKVFISSHLVPGHLDASGTRKKFLHEPVPKLEFVRTLLIDNYDSYTYNIFQELSIINGMPPVVIRNDEWTWKEVYHYLYEERTFDNIVISPGPGSPTCPSDIGICLRLLLECIDIPILGVCLGHQALGYVHGAEVVHAPEPFHGRLSDIEHNGCQLFHEIPSGRSSGFKVVRYHSLVIDPKSLPKELIPIAWTSTAETLPFQGVKRSNSFLNASKENKDIFNGMSELSDDSKDVKGGKVLMGIMHSSRPHYGLQFHPESVATCYGRQLFKNFRKITEDYWLLLMSTSFNERRAHYAACMQVPNLDPLSRSVAKRGHLVNKLIERRTAEVDGTLNLSHPGHSVKFLKMTWKKLDCSASQVGGADNIFCELFGDQEAKNSFWLDSSSIEKERARFSFMGGKGGSLWKQLSFRLSNRSDRMCKGGGHLSVEDANGHVISKFLEDGFFDYLDKELLSFCFDEKDYEGLPFDFYGGYIGYIGYDLKAECGVASNRHRSKTPDACLFFTDNVIVIDHQYDDIYTLSLHDGSTSTTSRLEDLEQRLLNLRAFTPRRLQSQASRGFSVVELKSGFSAEKSREQYIKDVENCQEFIKEGESYELCLTTQMRMKLGGIDSLELYRNLRIRNPAPYAAWLNFSRENLSICCSSPERFLRLDRNAILEAKPIKGTIARGSTPKEDEFLKLQLECSEKDQAENLMIVDLLRNDLGRVCETGSVHVPHLMEIESYATVHTMVSTIRGKKRSDASAIDCVRAAFPGGSMTGAPKLRSMELLDHLENCSRGIYSGCIGFFSYNQAFDLNIVIRTVVIHEGEASVGAGGAITALSDPNDEYEEMLLKTRAPIKAVLEHQSSIFSSDAQK

ADCS

Probable aminodeoxychorismate synthase, chloroplastic

895 amino acids

Bifunctional enzyme that catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine. In the first step, a glutamine amidotransferase generates ammonia that is channelled between the binding sites of glutamine and chorismate and used along with chorismate in the second step, catalyzed by aminodeoxychorismate synthase, to produce ADC. Required for the synthesis of 4-aminobenzoate (PABA), an important component in tetrahydrofolate biosynthesis. Does not possess ADC lyase activity (By similarity).

In the C-terminal section; belongs to the anthranilate synthase component I family.

99.227 kDa

MAALRLPTPPPPRAPAPWLHSSHRRRVAAPRGAGGGGGGGGAVPPPPVRTLLIDNYDSYTYNIFQELSVVNGVPPVVVRNDEWTWRDVYRWVYKERAFDNIVISPGPGSPACPSDIGIGLRILCECGDIPILGVCLGHQALGFVHGAKIVHAPEAIHGRLSELEHNGCYLFNHIPSGINSGFKVVRYHSLVIEPDSLSEDLISIAWTASPKMLSFLESDKPDITSSTLWGSLDNLFVTNQSECSTTDGKMPSINDASELDGYRVLMGVRHSTRPHYGVQFHPESVATHYGRQIFQNFKKITTDFGLQTPLLQERKVHSIGKLERSQISSPDLKNFVANDLLHSARLKLWDSVGPCALPKRSSGDKCLRLQWKKIDNFLNRIGGSENIFSVLFGHHSAEDTFWLDSSSVDQNRARFSFMGGKGGPLWKQMTFHLASQRANCGGNLTIRDAYGCTVRNFLKDGFLDFLDKEMQSIQYIEKDYEGLPFDFHGGFVGYIGYGLKVECDASSNSAKSSTPDACFFFADNLVVVDHNNGDVYILSLHDEYSSGNGDGDYQNSIHSLWLANTEKKLLRMDAMAPRLSINGNSSINGNSFTISSSVNKQRFVIEKSKDEYIRDVQSCLDYIRDGESYELCLTTQMKRRTDYMDALKLYLKLRKQNPAPYAAWLNFSSENLSICCSSPERFLRLDRNAILEAKPIKGTIARGRTPEEDECLRLQLKYSEKDQAENLMIVDLLRNDLGKVCEPGSVHVPRLMDVESYKTVHTMVSTIRGTKMSDLSPVDCVKAAFPGGSMTGAPKVRSMEILDSLETSPRGIYSGSVGFFSYNKTFDLNIVIRTVVLHNGEASIGAGGAIVALSDPEAEYNEMLLKAKAPTKVVEECSQQIYNPDRSDSMQTTVS