Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
Function
Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.
Similarity
Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.
Sequence
MSSERAQFAAEVAEVERWWKSPRFARVNRPYTAADVVSKRGTIKINYPSDVQGKKLWKLLSEHAKNGTPSHTYGALDPVQVTQMAKYLETVYVSGWQSSSTASSSNEPGPDLADYPSNTVPNKVEHLFMAQLFHDRKQREARSRMSDAELANTPVIDYLRPIVADADTGHGGLTAVMKLTKMFVEKGAAGIHIEDQAPGTKKCGHMAGKVLVPIQEHINRLVAIRLQYDIMGVENLVVARTDSEAATLITSNIDDRDHPFIQGSTNPSLPPLNNVMVEAEAQGKTGDQLQAIEDGWIKAANLQLFPQALAQALANEGASRSTVEKLVARVSRLSWPQAVAVAQKEFGLKQVPYWNWDAPRTREGYYRYQGGTECAIHRANAFAPYADLLWMETKKPILAQAKEFAAGVHAVHPGQWLAYNLSPSFNWEAAGLNAQDMQAYVWELGKLGFVWQFITLAGLHSNAYISDLFAQNFAKTGMKAYVELVQSREREIGCDVLTHQKWSGADYADSLIKTVTGGVSSTAAMGAGVTESQFTSKL