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ACTTR

Gene
ACTTR
Protein
Transcription activator ACTTR
Organism
Alternaria alternata
Length
435 amino acids
Function
Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) ACT-toxins responsible for brown spot of tangerine disease by the tangerine pathotype which affects tangerines and mandarins (Probable). ACT-toxins consist of three moieties, 9,10-epoxy-8-hydroxy-9-methyl-decatrienoic acid (EDA), valine and a polyketide (PubMed:22846083). ACT-toxin I is toxic to both citrus and pear; toxin II the 5''-deoxy derivative of ACT-toxin I, is highly toxic to pear and slightly toxic to citrus (PubMed:22846083). On cellular level, ACT-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K(+) after a few minutes of toxin treatment (PubMed:22846083).
Mass
47.745 kDa
Sequence
MLQCAPKKNERLRGSCDFCTQSKLRCNKNKPSCRRCTIQQQPCVYSVARRTGRPPKRPRKANDGQEANEQHGDQDPVTSTPGGSCQQQSNHLLDVEGDGANFTLADASTTAQDRETAACTALDNALLMGGTFGFSSLLDDPLIQSDDFLSFSLCMPPGEEEGHMASPCSPPILPSIDVPHLPARFGFLESSVESGLHGRNGPHLIEQPDKTVPSSFSEMEKIYDEGLTFSGLDSAINAVTNNGKGEPSIPGTMAAHPHSKRQCFCSTSMSKLQMLVSHPTLCQKNSRARFDMTLFLEEVVFSIYRDVLQCLVCQSKSLHSLASLCICTDWVIEALRDVAQDLSSGQDNLGGFRAGLCPPKDKFSICVGRFVLDDQLRESCTRSLVRYRLRKLIPIMDTMMKLNYRGAGGALSQAIRTMVEDVRHKIESALGMMEL