abcG5

ABC transporter G family member 5

1509 amino acids

Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.

170.937 kDa

MVKQDPRDKSSYSPNLSIPINNQEEPTLNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNKNNNNNNIKHKDEENDFEDSIYQIAKEHEGEEDDEYFPIPLDELMPNHENDELTKKIKQTRPEDKTGLYVYCRNATYTVKHRENKKVKIKLLDDVSFFLRPKQMTLILGTPGCGKSTIFQMLAGQLKDKHFEGELLFNGHPINHKNHHRDISYVTQDDIHVPTLTVKETFRFALDCLGKKELTREEKQVSVDNCMKLLGLKHAENTLVGDNFIRGISGGQKKRVTIGVGVIKGSNLLLMDEPTSGLDSSTSFEILSDVKKFVTYGYSPALITLLQPSVQLTSLFDNLMIMSKGKICYFGPMNRALGYFKKLGFACPSHNNPAEFFQEVVDAPERYSFIHPPKCKTSDDFVKAYRESDIYLELMEKMDANKDGIVDDNKPKVLVDSTAKELGMYPHGIGYQTKICLKRGFIMISRNYYNFATRVFKGIFFGLLLGTLYWRIGHNQSGGMERFGLLFFIMTTIIFSSFAAVNSFFGERKVFYSQKALHYYKTGAYFISSIICDIPAGLIEVAFFGPIVYWLANLRPVFIRFVYFMILLFITDNLSLSFAKMCAAISPTIEIANVTASVILSIWLLFSGFTAPKNDIGGWWIWLYYISPYTWIFQGLSINEFTYQAYGCKDSELIPPRTPQNLLPYPEGFGGNQVCQYTSGEQIMDAFGINNPDYFKWIVYAILGAYIVFFYSVCFFALKYLNFEDKKSKLAVKKLKKKKKVIVCKEDEEPNCKVTTEALERVSDDNDDNADISNYDDDTVIDMKSPLTSPNYNNNNNLSGSGNNIKRRKVKTPSTLSPMVNSPLTNLSPMVNTPSKNGNHSKQKPISTSQKDISSETGSYLQFKKLCYAVDVKADDPDNPKKKKSQRLQLLTDIDGYVKPGQMLALMGPSGAGKSTLLDVLAQRKTGGHITGEILINGKPPSEFTNRIRAYVEQMDVLPPTQTVREAIAFSARCRLPPEVTKEEREIFVDKIVEVLSLSSIKDLKIGVLGNGLSVSQRKRVNIGVELASNPEILFLDEPTSGLDSGDAFKVIDVVNKIAKVMNRTVICTVHQPSAAIFEFFDQLLLLKKGGETIYFGPLGNQSSVILDYCDKLGMHIKPHINPADFVMTLADEGKMVEGPNGEQEHLDAKKAYFESNICKKEYEIMEGQLIPDDFVVKTYDSRFASSWMTQFRALCMRSWLSRLRRPAIFVSNCLRSILLAVLLGTLFVRMDYEQKDARSRVSLLFFSFLFAGMVAIGNIPTTVLERGVFYREVTAGFYHSTAYMISYVLTSYPFILSTGILYIIPTFWIAGLDSGRHSSKFWYCLFIFIITYIMYDAFALCLAVCLPNEVMASTICGIGLSLATLFGGFVIARPNYPSAYYWCHYLDWLRYPLEASCTNEFTGLTFVCTNNKGAVPIPIIENGVQIAIKYYCPITNGDDFMLTYGFHKFMRYIDIAAIFGYIFIFVGLSFWGFKKVRWLNR

Abcg5

ATP-binding cassette sub-family G member 5

652 amino acids

ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:16352607, PubMed:16867993, PubMed:18402465). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:12444248, PubMed:14504269, PubMed:14657202, PubMed:19846887, PubMed:25378657). Required for normal sterol homeostasis (PubMed:12444248, PubMed:14657202). The heterodimer with ABCG8 has ATPase activity (PubMed:16352607, PubMed:16867993).

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

73.244 kDa

MGELPFLSPEGARGPHINRGSLSSLEQGSVTGTEARHSLGVLHVSYSVSNRVGPWWNIKSCQQKWDRQILKDVSLYIESGQIMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQDCFSYVLQSDVFLSSLTVRETLRYTAMLALCRSSADFYNKKVEAVMTELSLSHVADQMIGSYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANQIVLLLAELARRDRIVIVTIHQPRSELFQHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLECAFKESDIYHKILENIERARYLKTLPTVPFKTKDPPGMFGKLGVLLRRVTRNLMRNKQAVIMRLVQNLIMGLFLIFYLLRVQNNTLKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYHKWQMLLAYVLHVLPFSVIATVIFSSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSIVALLSISGLLIGSGFIRNIQEMPIPLKILGYFTFQKYCCEILVVNEFYGLNFTCGGSNTSMLNHPMCAITQGVQFIEKTCPGATSRFTANFLILYGFIPALVILGIVIFKVRDYLISR

Abcg5

ATP-binding cassette sub-family G member 5

652 amino acids

ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane. Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile. Required for normal sterol homeostasis. The heterodimer with ABCG8 has ATPase activity.

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

73.372 kDa

MSELPFLSPEGARGPHNNRGSQSSLEEGSVTGSEARHSLGVLNVSFSVSNRVGPWWNIKSCQQKWDRKILKDVSLYIESGQTMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFVNGCELRRDQFQDCVSYLLQSDVFLSSLTVRETLRYTAMLALRSSSADFYDKKVEAVLTELSLSHVADQMIGNYNFGGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANHIVLLLVELARRNRIVIVTIHQPRSELFHHFDKIAILTYGELVFCGTPEEMLGFFNNCGYPCPEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLESAFRQSDICHKILENIERTRHLKTLPMVPFKTKNPPGMFCKLGVLLRRVTRNLMRNKQVVIMRLVQNLIMGLFLIFYLLRVQNNMLKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSDQESQDGLYQKWQMLLAYVLHALPFSIVATVIFSSVCYWTLGLYPEVARFGYFSAALLAPHLIGEFLTLVLLGMVQNPNIVNSIVALLSISGLLIGSGFIRNIEEMPIPLKILGYFTFQKYCCEILVVNEFYGLNFTCGGSNTSVPNNPMCSMTQGIQFIEKTCPGATSRFTTNFLILYSFIPTLVILGMVVFKVRDYLISR

ABCG5

ATP-binding cassette sub-family G member 5

651 amino acids

ABCG5 and ABCG8 form an obligate heterodimer that mediates Mg(2+)- and ATP-dependent sterol transport across the cell membrane (PubMed:27144356). Plays an essential role in the selective transport of dietary plant sterols and cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile (PubMed:11099417, PubMed:11138003, PubMed:27144356, PubMed:15054092). Required for normal sterol homeostasis (PubMed:11099417, PubMed:11138003, PubMed:15054092). The heterodimer with ABCG8 has ATPase activity (PubMed:16893193, PubMed:20210363, PubMed:27144356).

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

72.504 kDa

MGDLSSLTPGGSMGLQVNRGSQSSLEGAPATAPEPHSLGILHASYSVSHRVRPWWDITSCRQQWTRQILKDVSLYVESGQIMCILGSSGSGKTTLLDAMSGRLGRAGTFLGEVYVNGRALRREQFQDCFSYVLQSDTLLSSLTVRETLHYTALLAIRRGNPGSFQKKVEAVMAELSLSHVADRLIGNYSLGGISTGERRRVSIAAQLLQDPKVMLFDEPTTGLDCMTANQIVVLLVELARRNRIVVLTIHQPRSELFQLFDKIAILSFGELIFCGTPAEMLDFFNDCGYPCPEHSNPFDFYMDLTSVDTQSKEREIETSKRVQMIESAYKKSAICHKTLKNIERMKHLKTLPMVPFKTKDSPGVFSKLGVLLRRVTRNLVRNKLAVITRLLQNLIMGLFLLFFVLRVRSNVLKGAIQDRVGLLYQFVGATPYTGMLNAVNLFPVLRAVSDQESQDGLYQKWQMMLAYALHVLPFSVVATMIFSSVCYWTLGLHPEVARFGYFSAALLAPHLIGEFLTLVLLGIVQNPNIVNSVVALLSIAGVLVGSGFLRNIQEMPIPFKIISYFTFQKYCSEILVVNEFYGLNFTCGSSNVSVTTNPMCAFTQGIQFIEKTCPGATSRFTMNFLILYSFIPALVILGIVVFKIRDHLISR

ABCG5

ABC transporter G family member 5

649 amino acids

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

73.314 kDa

MEKQGCEIEALDIDYNIFVRKINVNPFGIFRRKPRPEADQPVKTEEESLKLEDETGNKVKHVLKGVTCRAKPWEILAIVGPSGAGKSSLLEILAARLIPQTGSVYVNKRPVDRANFKKISGYVTQKDTLFPLLTVEETLLFSAKLRLKLPADELRSRVKSLVHELGLEAVATARVGDDSVRGISGGERRRVSIGVEVIHDPKVLILDEPTSGLDSTSALLIIDMLKHMAETRGRTIILTIHQPGFRIVKQFNSVLLLANGSTLKQGSVDQLGVYLRSNGLHPPLHENIVEFAIESIESITKQQRLQESRRAAHVLTPQTTLQEKRSEDSQGESKSGKFTLQQLFQQTRVADVGTMNIATEFTRDFANSRLEETMILTHRFSKNIFRTKELFACRTVQMLGSGIVLGLIFHNLKDDLKGARERVGLFAFILTFLLTSTIEALPIFLQEREILMKETSSGSYRVSSYAVANGLVYLPFLLILAILFSTPVYWLVGLNPSFMAFLHFSLLIWLILYTANSVVVCFSALVPNFIVGNSVISGVMGSFFLFSGYFISNHEIPGYWIFMHYISLFKYPFEGFLINEFSKSNKCLEYGFGKCLVTEEDLLKEERYGEESRWRNVVIMLCFVLLYRFISYVILRCRCSQRSFKTTLA