abcG1

ABC transporter G family member 1

793 amino acids

Belongs to the ABC transporter superfamily. ABCG family.

89.047 kDa

MDSNNNNNNENEAFSGASESSEFRKIVEENENEREFEQSNPSPPEYSNYENKDDGINLETINPNISLDNNNNNNQNNQNNQNNNNNNNNQNNNIINNLNKKNKKRSTFKNRIDFSFKDINHYVQITEKGKKKKISKQILTNINGHIESGTIFAIMGPSGAGKTTLLDILAHRLNINGSGTMYLNGNKSDFNIFKKLCGYVTQSDSLMPSLTVRETLNFYAQLKMPRDVPLKEKLQRVQDIIDEMGLNRCADTLVGTADNKIRGISGGERRRVTISIELLTGPSVILLDEPTSGLDASTSFYVMSALKKLAKSGRTIICTIHQPRSNIYDMFDNLLLLGDGNTIYYGKANKALEYFNANGYHCSEKTNPADFFLDLINTQVEDQADSDDDDYNDEEEEIGGGGGGSGGGAGGIEDIGISISPTMNGSAVDNIKNNELKQQQQQQQQQQQSTDGRARRRIKKLTKEEMVILKKEYPNSEQGLRVNETLDNISKENRTDFKYEKTRGPNFLTQFSLLLGREVTNAKRHPMAFKVNLIQAIFQGLLCGIVYYQLGLGQSSVQSRTGVVAFIIMGVSFPAVMSTIHVFPDVITIFLKDRASGVYDTLPFFLAKSFMDACIAVLLPMVTATIVYWMTNQRVDPFYSAAPFFRFVLMLVLASQTCLSLGVLISSSVPNVQVGTAVAPLIVILFFLFSGFFINLNDVPGWLVWFPYISFFRYMIEAAVINAFKDVHFTCTDSQKIGGVCPVQYGNNVIENMGYDIDHFWRNVWILVLYIIGFRVLTFLVLKLKSRNKFKQE

ABCG1

ABC transporter G family member 1

740 amino acids

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

82.331 kDa

MARIVAANDDDSMELNTISSIHDSTLGQLLKNVSDVRKMAIGDETPVHESLNQDYNDGYMRTVPFVLSFDNLTYNVSVRPKLDFRNLFPRRRTEDPEIAQTARPKTKTLLNNISGETRDGEIMAVLGASGSGKSTLIDALANRIAKGSLKGTVKLNGETLQSRMLKVISAYVMQDDLLFPMLTVEETLMFAAEFRLPRSLPKSKKKLRVQALIDQLGIRNAAKTIIGDEGHRGISGGERRRVSIGIDIIHDPILLFLDEPTSGLDSTSAFMVVKVLKRIAQSGSIVIMSIHQPSHRVLGLLDRLIFLSRGHTVYSGSPASLPRFFTEFGSPIPENENRTEFALDLIRELEGSAGGTRGLIEFNKKWQEMKKQSNRQPPLTPPSSPYPNLTLKEAIAASISRGKLVSGGESVAHGGATTNTTTLAVPAFANPMWIEIKTLSKRSMLNSRRQPELFGIRIASVVITGFILATVFWRLDNSPKGVQERLGFFAFAMSTMFYTCADALPVFLQERYIFMRETAYNAYRRSSYVLSHAIVSFPSLIFLSVAFAATTYWAVGLDGGLTGLLFYCLIILASFWSGSSFVTFLSGVVPSVMLGYTIVVAILAYFLLFSGFFINRNRIPDYWIWFHYMSLVKYPYEAVLQNEFSDATKCFVRGVQIFDNTPLGELPEVMKLKLLGTVSKSLGVTISSTTCLTTGSDILRQQGVVQLSKWNCLFITVAFGFFFRILFYFTLLLGSKNKRR

ABCG1

ATP-binding cassette sub-family G member 1

678 amino acids

Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620).

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

75.592 kDa

MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER

Abcg1

ATP-binding cassette sub-family G member 1

666 amino acids

Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP (PubMed:14668945). The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (By similarity).

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

74.033 kDa

MACLMAAFSVGTAMNASSYSAAMTEPKSVCVSVDEVVSSNVDEVETDLLNGHLKKVDNNFTEAQRFSSLPRRAAVNIEFKDLSYSVPEGPWWKKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGMPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLPCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIVCTIHQPSAKLFELFDQLYVLSQGQCVYRGKVSNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDADYKRDLGGDTDVNPFLWHRPAEEDSASMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMSVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPAYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIAETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER