AAEL009382

Gene

AAEL009382

Protein

Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66

Organism

Aedes aegypti

Length

635 amino acids

Function

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code (By similarity).

Similarity

Belongs to the ROX family. NO66 subfamily.

Mass

71.791 kDa

Sequence

MSAVSSIFDTPIPSAAKSSPSGSNKRPLAQNGHHSGEKQSKKSKKASKKQLIDLLVQEHARELSQNDSSASTVSTPKKKKKKNASASDINTSASKNVNAAKKKPKEGLKINLQNSKKKRKNFEVLNSSQQHADDALVETSFNGESLKNNSNHSTPVSKKPKKKNKQMPHPLAGTPNLAIKQEPQTPKANGMQRTSAQDSIVVGREKFAWVIHPTPVEDFMINYWEKKPLLIQRKNPSYYSNLLSRAKIDEMLRQNNIEYTKNIDVTSYREGQRETHNPDGRVLPPDMWSFYEEGCSIRMLNPQTYLPGVYEMNVKLQEFFHCMTGANFYLTPPNSQGFAPHYDDIEAFVLQVEGRKHWKLYSPREPAEMLARVSSPNFTQEEIGTPILEVVLEPGDLLYFPRGIIHQASTVPGHHSLHVTMSVYQKNCWADLLELFFPHALAQAAETHFDLRRGIPLNLHQHFGIVHSDSETPARKQLISHIKSLVDKVFSEDAIDSAVDQLAKRFQHDALPPLISNTEQSTTVYGSSFSHNPDGTVSLRVPFTENSTVRLLRCNVLRLVSEEEKLRIYYHTDNSREYHEYEPNFLEIDQDAALGVELLVKMYPHPVAIRDLPVEDKIEFAKSLWEKGLIVVHGQ

Protein

Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66: AAEL009382