Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Probable component of kinase complex containing SMG1 and recruited to stalled ribosomes (By similarity).
Similarity
Belongs to the SMG8 family.
Sequence
MNPVESFVFPDIPKTIRDVLFKPDKQMIIVGVIGKSSNPTCNKLIGFNLLTTHPALTDSKCCEGRIKFYFENDGNVLYLHFETTFDQQVMAEQLAKAIDTGVQDNFVNFNSYVRSRFARMLLFAIQVCHMIVLVEPTSVFDTSYLSIFKSLKIIREKYVLKFLPKLLKASNVGNYMGKEARLCSPRFIFLFEGTCDIKPEDVEKLEALECAVEEDIYKMLRTEFIITNNSAMSLFSIPRSKKFVFFSSDSKAKSDPLLDSIDMLMEYLDKPAAGQQGDKDEEEFMNKLRPCAGYGMSAWSVGAGAPKTERERSVLTLIKKHVAEAFEHGFDDSVSKYRGRSHFAVPGFKSWFEGFKFLHKIFIENPDNQNYEPVDVDYKAYLENFHKVIDIDERFFADVCEHGMELAMVNYKEMLPHHYSGTFHEKKYQQARELFLRYARGPEVEKHELKLKDYCDSIWLNGKQQCEYPSLRGNPCALGKHKANDPMDHSSGVVFVSACNCGRTQGHREDPYTIRQANYEFYQLIAKSCSNCTLLERIKFPVFEPSSSDFRAAEFINKNLSNLMSLENSNRTPDTGTHPPMTNDHSPHLSGSQKSQDSASNLTFSIDDKEENETHAKNYASQGDADEALEQENLNEIVIKVGEHADQTDKEKAILRQPSTTEYLPGMLHATSPIGLLPQFPSWSLVCLGPSSIYTHNSGLPEHIQSGFLSGSNFLLPWDVSVRLEHAQSWAASYEKIRNRKKNVSQSKSSDSSNNFTLKIFIGIEYECLRGHRFIMSGPDTVLRGGSGIVRDSGSKVVFNDMPIYFPCLCRNSNVAQLMRVHIVTPKAPVNVILEPKAKIFQNNMQSNFTFTTGQPEPIKLTQSAYWILRLPFVYEGDEGPLMPPSEVNASNAAMHGILLAGMYGIKESEISEELL