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A622

Gene
A622
Protein
Isoflavone reductase homolog A622
Organism
Nicotiana tabacum
Length
310 amino acids
Function
Probable NADPH-dependent oxidoreductase that binds NADPH in vitro. Does not seem to be involved in the NADPH-dependent reduction of phenylcoumaran benzylic ethers (PubMed:12369619). Reductase that may be involved in a late step of tobacco alkaloid biosynthesis. Maybe involved in either the formation of a nicotinic acid-derived precursor or the final condensation reaction of tobacco alkaloids (PubMed:19002761).
Similarity
Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.
Mass
34.654 kDa
Sequence
MVVSEKSKILIIGGTGYIGKYLVETSAKSGHPTFALIRESTLKNPEKSKLIDTFKSYGVTLLFGDISNQESLLKAIKQVDVVISTVGGQQFTDQVNIIKAIKEAGNIKRFLPSEFGFDVDHARAIEPAASLFALKVRIRRMIEAEGIPYTYVICNWFADFFLPNLGQLEAKTPPRDKVVIFGDGNPKAIYVKEEDIATYTIEAVDDPRTLNKTLHMRPPANILSFNEIVSLWEDKIGKTLEKLYLSEEDILQIVQEGPLPLRTNLAICHSVFVNGDSANFEVQPPTGVEATELYPKVKYTTVDEFYNKFV