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A27L

Gene
A27L
Protein
14 kDa fusion protein
Organism
Vaccinia virus (strain WR 65-16)
Length
136 amino acids
Function
This protein appears to play an important role in virus penetration at the level of cell fusion. The N-terminal proximal region is essential for fusion ability. Essential in fusing the outermost of the two Golgi-derived membranes enveloping the virus with the plasma membrane, and in its subsequent release extracellularly.
Similarity
Belongs to the poxviruses fusion protein family.
Mass
15.837 kDa
Sequence
MLEFFRPPRARSPRELVQLLPEAWTTSRSSTGSANPSASRKPARYPRIHAPELQSGEARWPLWSRIRPLEDPLKQRLTNLEKKITNVTTKFEQIEKCCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTGRRPYE

Gene
A27L
Protein
14 kDa fusion protein
Organism
Vaccinia virus (strain Copenhagen)
Length
110 amino acids
Function
Structural protein involved in the envelopment of mature virion (MV) to form the wrapped virion (WV). The wrapping consists of the addition of Golgi membranes to the mature virion. Participates in mature virion (MV) movement within the infected cell. May play an indirect role in MV-cell fusion (By similarity).
Similarity
Belongs to the chordopoxvirinae A27 protein family.
Mass
12.616 kDa
Sequence
MDGTLFPGDDDLAIPATEFFSTKADKKPEAKREAIVKADEDDNEETLKQRLTNLEKKITNVTTKFEQIEKCCKRNDEVLFRLENHAETLRAAMISLAKKIDVQTGRRPYE

Gene
A27L
Protein
14 kDa fusion protein
Organism
Variola virus (isolate Human/India/Ind3/1967)
Length
110 amino acids
Function
Structural protein involved in the envelopment of mature virion (MV) to form the wrapped virion (WV). The wrapping consists of the addition of Golgi membranes to the mature virion. Participates in mature virion (MV) movement within the infected cell. May play an indirect role in MV-cell fusion (By similarity).
Similarity
Belongs to the chordopoxvirinae A27 protein family.
Mass
12.485 kDa
Sequence
MDGTLFPGDDDLAIPATEFFSTKAAKKPEAKREAIVKADGDNNEETLKQRLTNLEKKITNVTTKFEQIEKCCKRNDDVLFRLENHAETLRAAMISLAKKIDVQTGRRPYE