The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.

Belongs to the ABC transporter superfamily. UvrA family.

962 amino acids

METLRIMSGKIVIKGAREHNLQNVDLELPRDKFIVITGISGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGQMKKPEMDYIEGLSPAISIDQKTTRVNPRSTVGTITEIYDYLRLLFARIGKPHCYLCGREIEQQTSTQIVDRIMDDGEGERIIILAPVVRDRKGEHQRVFERLREQGFVRVRVDGEIHDLEDEFDLDRNRKHSIDVVVDRLVVRRDTEFRKRLADSVETALQLGEGTVRVPSTMTPGEERIYSEHFACPGTAGINFEEISPRMFSFNSPHGACPECNGLGSKLEIDPDLVVPYPERSINEGAIVPWSKSGKRDNYYHQMLRAVAEHYGFSLDTPFRDLDEEHRRAILYGTDEKIQFVFQRKNRTYRVNRRFEGVIPRMERIYMETKSNYMRTYIGRFMSNHACPVCGGSRLRPESLSVTINGRSIHDVVEMSIREAHEFFDSLKLTEREEYIAREVLKEIRERLRFLIDVGLDYLTLSRSSGTLSGGEAQRIRLATQIGSGLVGVLYILDEPSIGLHQRDNRRLIETLKRLRDLGNTLIVVEHDEETILSADHVVDIGPGAGEHGGCVVAEGTPEEIMEDPDSLTGAYLSGRETIPLPEVRRRPSGRYLTVRGAAENNLREIDVRIPLGLFTCVTGVSGSGKSTLVNDILYRGVYERLNHKHMNAGRHTDIEGLQHIDKVVMIDQSPIGRTPRSNPATYTGVFTHIRELFAQTPEARKRGYRPGRFSFNVKGGRCEACGGDGIIKIEMHFLADVYVPCEVCRGRRYNEETLEIRYRGRNIAEVLDMTVEEALEFFENIPQVRRKLQTLYDVGLGYIKLGQPATTLSGGEAQRVKLAKELSRRSTGSTLYILDEPTTGLHFDDIKKLLNVLGRLVDAGNTAVVIEHNLDVIKSADHIIDLGPEGGERGGLVVAEGTPEEVAASGTHTGRFLREVLADERSQKVPVGQDTG

108.4 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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