Sodium-independent organic anion transporter which exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones. It is also specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate, butyrate and valerate. May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs at the sinusoidal membrane of hepatocytes (By similarity).

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

552 amino acids

MAFQDLLDQVGGLGRFQILQMLLLCISSLITYPHILLENFTAAVPGHQCWVHILNNNTDSANATGTLSPDALLRISIPLDSNLRPEKCRRFSRPQWQLLNLNRTFPNITDLDTESCVDGWVYDQSIFTSTIVTEWDLVCESQSLKSMAKFLFMAGMLVGSIVYGHLSDRFGRRLIFRCCLLQLAITDTSAAFAPTYLIYCSLRFLAGFSTMSILTNCTVLIVEWTVPRFQVMGMTLSICAACLGQIILGGLAFAIRDWHTLQLVFSVPLFVLFLSSRWLAESARWLIITNRPEEGLKELKKAAHRNGRKNAGDALTMEVLRSAMQEELEAAQIKSSVFDLFRTPNLRKRICLLSFVRFANFMSFFGLILHLQYMGSNVFLFQVLFGAVNLPANCVAFWALNHLGRQVSQTLFLFLLGISILAITFVPQEMQTLRMAVSALGIAVSSVTLMCSFAHGNELTPTVLRVTASGFLGIASNIGAALAPLLMILTVYSPHLPWIIYGVCSILGGLVVPLLPETRNKPLPDSIQEVEKERKDSRKAKPEGTFMKVTQF

61.5 kDa

(Note: Representative image - actual molecular weight may vary depending on tag type and expression method)

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